Dogs represent such a rich potential resource to further understand diseases and genetic traits.Comparing the genomes of three species of canine,human,and rat in terms of genome analysis,it is found that dogs are high...Dogs represent such a rich potential resource to further understand diseases and genetic traits.Comparing the genomes of three species of canine,human,and rat in terms of genome analysis,it is found that dogs are highly conservative with humans and rats.The special population structure of dogs makes it a good model for studying the diversity of morphology and behavior,the genetic basis of mammalian evolution,and dis-eases.This article gives a brief review of recent advances in domestic dog origin and evolution,genomic structure,genetic variation in dog pheno-typic characteristics,and gene mapping.These research results are expected to provide a better theoretical basis for canine genetic breeding re-search and provide new ideas and methods for the prevention,diagnosis and treatment of human diseases.展开更多
As the only working dog independently developed and bred in China,Chinese Kunming dog(CKD)was approved as a new breed by the Chinese National Livestock and Poultry Genetics Commission in 2007.Now CKD is widely used by...As the only working dog independently developed and bred in China,Chinese Kunming dog(CKD)was approved as a new breed by the Chinese National Livestock and Poultry Genetics Commission in 2007.Now CKD is widely used by the Chinese army and police and has been exported to Singapore,Thailand,Vietnam,North Korea,and other more than 10 countries as working dog.Previously published studies of CKD have focused on coat color genetics(Wang et al.2013)and reproduction performance(Wei et al.2018).The study by Wang et al.(2013)pointed out that the breed of CKD was developed in the 1950s by hybridizing German shepherd dogs(GSDs)imported from the Soviet Union with Kunming indigenous village dogs.展开更多
基金Supported by Special Project of Basic Work of Strengthening Police by Science and Technology of the Ministry of Public Security (2018GABJC27,2019GABJC29)Basic Research Program of Science and Technology Project from Yunnan Department of Science and Technology (Youth Project)(2019FD025)
文摘Dogs represent such a rich potential resource to further understand diseases and genetic traits.Comparing the genomes of three species of canine,human,and rat in terms of genome analysis,it is found that dogs are highly conservative with humans and rats.The special population structure of dogs makes it a good model for studying the diversity of morphology and behavior,the genetic basis of mammalian evolution,and dis-eases.This article gives a brief review of recent advances in domestic dog origin and evolution,genomic structure,genetic variation in dog pheno-typic characteristics,and gene mapping.These research results are expected to provide a better theoretical basis for canine genetic breeding re-search and provide new ideas and methods for the prevention,diagnosis and treatment of human diseases.
基金supported by the National Key R&D Program of China(2019YFA0707101)Key Research Program of Frontier Sciences of the CAS(ZDBS-LY-SM011)+1 种基金Innovative Research Team(in Science and Technology)of Yunnan Province(201905E160019)G.-D.W.is supported by the Youth Innovation Promotion Association of CAS.
文摘As the only working dog independently developed and bred in China,Chinese Kunming dog(CKD)was approved as a new breed by the Chinese National Livestock and Poultry Genetics Commission in 2007.Now CKD is widely used by the Chinese army and police and has been exported to Singapore,Thailand,Vietnam,North Korea,and other more than 10 countries as working dog.Previously published studies of CKD have focused on coat color genetics(Wang et al.2013)and reproduction performance(Wei et al.2018).The study by Wang et al.(2013)pointed out that the breed of CKD was developed in the 1950s by hybridizing German shepherd dogs(GSDs)imported from the Soviet Union with Kunming indigenous village dogs.
基金supported by the National Key Research and Development Program of China(2019YFA0707101)the Key Research Program of Frontier Sciences of the Chinese Academy of Sciences(2019YFA0707101)+5 种基金the Innovative Research Team(in Science and Technology)of Yunnan Province(201905E160019)the National Natural Science Foundation of China(81860255,31701133,81722019,and 31201712)Yunnan Applied Basic Research Projects for Kunming Medicine University Special Fund(2017FE468(-134))the Animal Branch of the Germplasm Bank of Wild Species,Chinese Academy of Sciences(the Large Research Infrastructure Funding)supported by the National Youth Talent Support Programsupported by the Hundred-Talent Program of Kunming Medical University。
