Aerobic exercise training alters gene expression in skeletal muscle,and miRNAs significantly contribute to motion response.However,the molecular mechanisms by which miRNAs regulate the response to exercise training ar...Aerobic exercise training alters gene expression in skeletal muscle,and miRNAs significantly contribute to motion response.However,the molecular mechanisms by which miRNAs regulate the response to exercise training are not well understood.Here,we found that the abundance of miR-378a-3p in skeletal muscle significantly decreased after exercise training.miR-378a-3p knockout mice showed increased insulin sensitivity,insulin-mediated glucose uptake.展开更多
基金supported by the National Natural Science Foundation of China(No.31830090,32102513)the Basic and Applied Basic Research Foundation of Guangdong Province,China(No.2019B1515120059)+1 种基金Shenzhen Science and Technology Program,Projects Subsidized by Special Funds for Science Technology Innovation and Industrial Development of Shenzhen Dapeng New District(Guangdong,China)(No.PT202101-16)the Agricultural Science and Technology Innovation Program(No.CAASZDRW202006).
文摘Aerobic exercise training alters gene expression in skeletal muscle,and miRNAs significantly contribute to motion response.However,the molecular mechanisms by which miRNAs regulate the response to exercise training are not well understood.Here,we found that the abundance of miR-378a-3p in skeletal muscle significantly decreased after exercise training.miR-378a-3p knockout mice showed increased insulin sensitivity,insulin-mediated glucose uptake.
