Microglia activation is observed in various neurodegenerative diseases.Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity.Some ide...Microglia activation is observed in various neurodegenerative diseases.Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity.Some identified microglia in specific states correlate with pathological hallmarks and are associated with specific functions.展开更多
Correction to:Translational Neurodegeneration(2023)12:5 https://doi.org/10.1186/s40035-023-00337-1 Following publication of this article[1],three errors were identified about the reference.Correction 1:136.Crocker TF,...Correction to:Translational Neurodegeneration(2023)12:5 https://doi.org/10.1186/s40035-023-00337-1 Following publication of this article[1],three errors were identified about the reference.Correction 1:136.Crocker TF,Brown L,Lam N,Wray F,Knapp P,Forster A.Information provision for stroke survi-vors and their carers.Cochrane Database Syst Rev.2021;11:CD001919.136.Menni C,Valdes AM,Polidori L,Antonelli M,Penamakuri S,Nogal A,et al.Symptom prevalence,duration,and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance:a prospective observational study from the ZOE COVID study.Lancet.2022;399:1618-24.展开更多
The impact of coronavirus disease 2019(COVID-19)pandemic on patients with neurodegenerative diseases and the specific neurological manifestations of COVID-19 have aroused great interest.However,there are still many is...The impact of coronavirus disease 2019(COVID-19)pandemic on patients with neurodegenerative diseases and the specific neurological manifestations of COVID-19 have aroused great interest.However,there are still many issues of concern to be clarified.Therefore,we review the current literature on the complex relationship between COVID-19 and neurodegenerative diseases with an emphasis on Parkinson’s disease(PD)and Alzheimer’s disease(AD).We summarize the impact of COVID-19 infection on symptom severity,disease progression,and mortality rate of PD and AD,and discuss whether COVID-19 infection could trigger PD and AD.In addition,the susceptibility to and the prognosis of COVID-19 in PD patients and AD patients are also included.In order to achieve better management of PD and AD patients,modifications of care strategies,specific drug therapies,and vaccines during the pandemic are also listed.At last,mechanisms underlying the link of COVID-19 with PD and AD are reviewed.展开更多
基金This research was funded by the National Natural Science Foundation of China(81971187,82171401,81971183,and 82101477)Shanghai Municipal Science and Technology Major Project(2018SHZDZX05)Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-01-E00046).
文摘Microglia activation is observed in various neurodegenerative diseases.Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity.Some identified microglia in specific states correlate with pathological hallmarks and are associated with specific functions.
文摘Correction to:Translational Neurodegeneration(2023)12:5 https://doi.org/10.1186/s40035-023-00337-1 Following publication of this article[1],three errors were identified about the reference.Correction 1:136.Crocker TF,Brown L,Lam N,Wray F,Knapp P,Forster A.Information provision for stroke survi-vors and their carers.Cochrane Database Syst Rev.2021;11:CD001919.136.Menni C,Valdes AM,Polidori L,Antonelli M,Penamakuri S,Nogal A,et al.Symptom prevalence,duration,and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance:a prospective observational study from the ZOE COVID study.Lancet.2022;399:1618-24.
基金supported in part by grants from the National Natural Science Foundation of China(Grant Nos.81971183,81971187,82171401,82001249)Shanghai Municipal Science and Technology Major Project(Grant No.2018SHZDZX05)+1 种基金Shanghai Sailing Program(Grant No.20YF1440200)Natural Science Foundation of Shanghai(Grant No.20ZR1445400).
文摘The impact of coronavirus disease 2019(COVID-19)pandemic on patients with neurodegenerative diseases and the specific neurological manifestations of COVID-19 have aroused great interest.However,there are still many issues of concern to be clarified.Therefore,we review the current literature on the complex relationship between COVID-19 and neurodegenerative diseases with an emphasis on Parkinson’s disease(PD)and Alzheimer’s disease(AD).We summarize the impact of COVID-19 infection on symptom severity,disease progression,and mortality rate of PD and AD,and discuss whether COVID-19 infection could trigger PD and AD.In addition,the susceptibility to and the prognosis of COVID-19 in PD patients and AD patients are also included.In order to achieve better management of PD and AD patients,modifications of care strategies,specific drug therapies,and vaccines during the pandemic are also listed.At last,mechanisms underlying the link of COVID-19 with PD and AD are reviewed.
