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Anti-Melanogenesis Effect of Daniellic Acid Isolated from <i>Daniellia oliveri</i>(Rolfe) Hutch. &Dalziel (Leguminosae) Oleoresin of Burkina Faso
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作者 Aminata P. Nacoulma Moussa Compaoré +4 位作者 Naamwin-so-Bawfu Romaric Meda Laurent Pottier Véronique Megalizzi Issa Some Martin Kiendrebeogo 《Open Journal of Medicinal Chemistry》 CAS 2021年第4期41-57,共17页
Over the past years, natural products have been used as useful candidates for prevention and treatment of skin disorders such as skin darkening. In this current research, <i><span style="font-family:Verd... Over the past years, natural products have been used as useful candidates for prevention and treatment of skin disorders such as skin darkening. In this current research, <i><span style="font-family:Verdana;">Daniellia oliveri</span></i><span style="font-family:Verdana;"> which was a potential source of cosmeceutical agent was selected to investigate its active components. Daniellic acid isolated from the oleoresin was characterized by using data from </span><sup><span style="font-family:Verdana;">1</span></sup><span style="font-family:Verdana;">H-NMR, </span><sup><span style="font-family:Verdana;">13</span></sup><span style="font-family:Verdana;">C-NMR, HSQC, IR, and online chemo-informatic analysis. The daniellic acid antioxidant, anti-proliferative, and tyrosinase inhibition capabilities were evaluated. This compound possessed an anti-DPPH and iron (III) reducing effect compared to quercetin. It was able to inhibit 9 tumor cells with IC</span><sub><span style="font-family:Verdana;">50</span></sub><span style="font-family:Verdana;"> going from 0.03 mM (U373) to 0.14 mM (Malme-3M). Interestingly daniellic acid inhibit</span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> tyrosinase activity with 1.20 mM as IC</span><sub><span style="font-family:Verdana;">50</span></sub><span style="font-family:Verdana;">. The tyrosinase inhibition mechanism was noncompetitive mixed-type with un-significant effect on cell melanogenesis. Daniellic acids induced a half-reduction of melanin production in B16F10 cell in IBMX stimulation (p</span></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">0.05). The same observation was effective in Malme-3M melanin production with a significant daniellic acid action than kojic acid (p</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">0.05) without reducing cell viabilities. This bioactive daniellic acid could explain the traditional uses of oleoresins from </span><i><span style="font-family:Verdana;">Daniellia oliveri</span></i><span style="font-family:Verdana;"> for genitor-urinary tract diseases treatments, wound healing, and skin ailments in Burkina Faso.</span></span></span></span> 展开更多
关键词 Daniellia oliveri Daniellic Acid Tyrosinase MELANOGENESIS Cytotoxicity
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