In a recent paper in Nature Cancer,Smith et al.demonstrate that mitochondrial DNA(mtDNA)mutations can confer a growth advantage to intestinal tumors by remodeling cell metabolism,particularly toward elevated de novo s...In a recent paper in Nature Cancer,Smith et al.demonstrate that mitochondrial DNA(mtDNA)mutations can confer a growth advantage to intestinal tumors by remodeling cell metabolism,particularly toward elevated de novo serine synthesis.1 For the reasons outlined below,in the past decade,the field of mtDNA biology has experienced a relative loss of relevance.The findings of Smith et al.breathe welcome new life into the complex field of mtDNA contributions to aging and cancer.展开更多
文摘In a recent paper in Nature Cancer,Smith et al.demonstrate that mitochondrial DNA(mtDNA)mutations can confer a growth advantage to intestinal tumors by remodeling cell metabolism,particularly toward elevated de novo serine synthesis.1 For the reasons outlined below,in the past decade,the field of mtDNA biology has experienced a relative loss of relevance.The findings of Smith et al.breathe welcome new life into the complex field of mtDNA contributions to aging and cancer.
