Introduction Hepatocellular carcinoma is the third leading cause of cancer deaths worldwide and mainly originates from chronic liver diseases[1].It is essential to establish a stable and effective model for studying h...Introduction Hepatocellular carcinoma is the third leading cause of cancer deaths worldwide and mainly originates from chronic liver diseases[1].It is essential to establish a stable and effective model for studying hepatocellular carcinomas.At present,chemical induction is the most common method to establish liver cancer models in mice,in which diethylnitrosamine(DEN)and carbon tetrachloride(CCl4)are the main inducers[2].It simulates well the natural formation process of liver cancer,but the induction time is long.Human primary liver cancer organoids retain livertissue function and genetic stability[3].展开更多
基金supported by the National Natural Science Foundation of China[91949125,82171545]the National Key R&D Program of China[2021YFA0804903].
文摘Introduction Hepatocellular carcinoma is the third leading cause of cancer deaths worldwide and mainly originates from chronic liver diseases[1].It is essential to establish a stable and effective model for studying hepatocellular carcinomas.At present,chemical induction is the most common method to establish liver cancer models in mice,in which diethylnitrosamine(DEN)and carbon tetrachloride(CCl4)are the main inducers[2].It simulates well the natural formation process of liver cancer,but the induction time is long.Human primary liver cancer organoids retain livertissue function and genetic stability[3].
