By means of cell culture, ~3H-thymidine (~2H-TdR) incorporation and c-fos oncogene dot plotting technique, it was found that endothelin (ET) and angiotensin (ANG Ⅱ) could promote proliferation and DNA synthesis of cu...By means of cell culture, ~3H-thymidine (~2H-TdR) incorporation and c-fos oncogene dot plotting technique, it was found that endothelin (ET) and angiotensin (ANG Ⅱ) could promote proliferation and DNA synthesis of cultured vascular smooth muscle cells (VSMCs) and myocardial cells, and stimulate expression of c-fos oncogene of VSMCs. However, atrial natriuretic peptide (ANP) antagonizes the above effects of ET and ANG Ⅱ.展开更多
Studies on the isolated rat heart perfusion model have proved that perfusion with high Ca_(2+) (4.5 mmol/L), high K^+ (8.7 mmol/L) or tree radical generating system (FRGS) significantly increases myocardial uptake of ...Studies on the isolated rat heart perfusion model have proved that perfusion with high Ca_(2+) (4.5 mmol/L), high K^+ (8.7 mmol/L) or tree radical generating system (FRGS) significantly increases myocardial uptake of liposomes. Intravenous injection of liposomes covalently combined with antibody of rat myocardial cells obviously elevates the target action of liposomes to myocardium. Liposome-carried SOD for treatment of rat myocardial ischemia-repertusion injury is much more effective than simple SOD. The results evidence that the liposome as drug carrier for treatment of ischemic heart diseases shows a broad prospect for its clinical use.展开更多
Most of the cytokines have an important effect on functional regulation for the cardiovascular system. Interleukin-8 (IL-8), an activator of neutrophils, is synthesized and released by mononucleic macrophage. It is fo...Most of the cytokines have an important effect on functional regulation for the cardiovascular system. Interleukin-8 (IL-8), an activator of neutrophils, is synthesized and released by mononucleic macrophage. It is found recently that IL-8 is also produced by vascular endothelial cells, and IL-8 derived from endothelial cells has a leukocyte adhesion inhibitor (LAI)-like effect, which limits leukocyte adhesion on vascular wall and regulates the interaction between leukocyte and endothelial cells. IL-8 induces chemotaxis展开更多
Studies on the isolated rat heart perfusion model have proved that perfusion with high Ca^(2+) (4.5 mmol/L), high K^+ (8.7 mmol/L) or tree radical generating system (FRGS) significantly increases myocardial uptake of ...Studies on the isolated rat heart perfusion model have proved that perfusion with high Ca^(2+) (4.5 mmol/L), high K^+ (8.7 mmol/L) or tree radical generating system (FRGS) significantly increases myocardial uptake of liposomes. Intravenous injection of liposomes covalently combined with antibody of rat myocardial cells obviously elevates the target action of liposomes to myocardium. Liposome-carried SOD for treatment of rat myocardial ischemia-reperfusion injury is much more effective than simple SOD. The results evidence that the liposome as drug carrier for treatment of ischemic heart diseases shows a broad prospect for its clinical use.展开更多
文摘By means of cell culture, ~3H-thymidine (~2H-TdR) incorporation and c-fos oncogene dot plotting technique, it was found that endothelin (ET) and angiotensin (ANG Ⅱ) could promote proliferation and DNA synthesis of cultured vascular smooth muscle cells (VSMCs) and myocardial cells, and stimulate expression of c-fos oncogene of VSMCs. However, atrial natriuretic peptide (ANP) antagonizes the above effects of ET and ANG Ⅱ.
文摘Studies on the isolated rat heart perfusion model have proved that perfusion with high Ca_(2+) (4.5 mmol/L), high K^+ (8.7 mmol/L) or tree radical generating system (FRGS) significantly increases myocardial uptake of liposomes. Intravenous injection of liposomes covalently combined with antibody of rat myocardial cells obviously elevates the target action of liposomes to myocardium. Liposome-carried SOD for treatment of rat myocardial ischemia-repertusion injury is much more effective than simple SOD. The results evidence that the liposome as drug carrier for treatment of ischemic heart diseases shows a broad prospect for its clinical use.
文摘Most of the cytokines have an important effect on functional regulation for the cardiovascular system. Interleukin-8 (IL-8), an activator of neutrophils, is synthesized and released by mononucleic macrophage. It is found recently that IL-8 is also produced by vascular endothelial cells, and IL-8 derived from endothelial cells has a leukocyte adhesion inhibitor (LAI)-like effect, which limits leukocyte adhesion on vascular wall and regulates the interaction between leukocyte and endothelial cells. IL-8 induces chemotaxis
文摘Studies on the isolated rat heart perfusion model have proved that perfusion with high Ca^(2+) (4.5 mmol/L), high K^+ (8.7 mmol/L) or tree radical generating system (FRGS) significantly increases myocardial uptake of liposomes. Intravenous injection of liposomes covalently combined with antibody of rat myocardial cells obviously elevates the target action of liposomes to myocardium. Liposome-carried SOD for treatment of rat myocardial ischemia-reperfusion injury is much more effective than simple SOD. The results evidence that the liposome as drug carrier for treatment of ischemic heart diseases shows a broad prospect for its clinical use.
