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Synergistic stimulation of surface topography and biphasic electric current promotes muscle regeneration
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作者 Indong Jun Na Li +8 位作者 Jaehee Shin Jaeho Park Young Jun Kim Hojeong Jeon Hyuk Choi Jae-Gu Cho Byoung Chan Choi Hyung-Seop Han Jae-Jun Song 《Bioactive Materials》 SCIE 2022年第5期118-129,共12页
Developing a universal culture platform that manipulates cell fate is one of the most important tasks in the investigation of the role of the cellular microenvironment.This study focuses on the application of topograp... Developing a universal culture platform that manipulates cell fate is one of the most important tasks in the investigation of the role of the cellular microenvironment.This study focuses on the application of topographical and electrical field stimuli to human myogenic precursor cell(hMPC)cultures to assess the influences of the adherent direction,proliferation,and differentiation,and induce preconditioning-induced therapeutic benefits.First,a topographical surface of commercially available culture dishes was achieved by femtosecond laser texturing.The detachable biphasic electrical current system was then applied to the hMPCs cultured on laser-textured culture dishes.Laser-textured topographies were remarkably effective in inducing the assembly of hMPC myotubes by enhancing the orientation of adherent hMPCs compared with flat surfaces.Furthermore,electrical field stimulation through laser-textured topographies was found to promote the expression of myogenic regulatory factors compared with nonstimulated cells.As such,we successfully demonstrated that the combined stimulation of topographical and electrical cues could effectively enhance the myogenic maturation of hMPCs in a surface spatial and electrical field-dependent manner,thus providing the basis for therapeutic strategies. 展开更多
关键词 TOPOGRAPHY Electrical field stimulation Femtosecond laser Human myogenic precursor cell Cell therapy
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