We present a multimodal ferrule-top sensor designed to perform the integrated epidetection of Optical Coberence Tomognphy(OCT)depth-profiles and micron-scale indentation by all-optical detection.By scarning a sample u...We present a multimodal ferrule-top sensor designed to perform the integrated epidetection of Optical Coberence Tomognphy(OCT)depth-profiles and micron-scale indentation by all-optical detection.By scarning a sample under the probe,we can obtain structural crosse soction images and identify a region of interest in a nonhomogencous sample.Then,with the same probe and setup,we can immediately target that area with a series of spherical indentation measurements,in which the applied load is known with aμN precision,the indentation depth with sub-/m precision and a maximum contact radius of 100 pm.Thanks to the visualization of the internal structure of the sample,we can gain a better insi ght into the observed mechanical behavior.The ability to impart a small,confined load,and perfomn OCT A scans at the same time,could lead to an altemative,high transverse resolution,Optical Coherence Elastography(OCE)sensor.展开更多
Lensless imaging is an approach to microscopy in which a high-resolution image of an object is reconstructed from one or more measured diffraction patterns,providing a solution in situations where the use of imaging o...Lensless imaging is an approach to microscopy in which a high-resolution image of an object is reconstructed from one or more measured diffraction patterns,providing a solution in situations where the use of imaging optics is not possible.However,current lensless imaging methods are typically limited by the need for a light source with a narrow,stable and accurately known spectrum.We have developed a general approach to lensless imaging without spectral bandwidth limitations or sample requirements.We use two time-delayed coherent light pulses and show that scanning the pulse-to-pulse time delay allows the reconstruction of diffraction-limited images for all the spectral components in the pulse.In addition,we introduce an iterative phase retrieval algorithm that uses these spectrally resolved Fresnel diffraction patterns to obtain high-resolution images of complex extended objects.We demonstrate this two-pulse imaging method with octave-spanning visible light sources,in both transmission and reflection geometries,and with broadband extreme-ultraviolet radiation from a high-harmonic generation source.Our approach enables effective use of low-flux ultra-broadband sources,such as table-top high-harmonic generation systems,for high-resolution imaging.展开更多
基金supported by the Dutch Technology Foundation (STW) under the OMNE program (13183)funding from LASERLABEUROPE under the EC's Seventh Framework Program (Grant agreement No.284464)the European Research Council (615170).
文摘We present a multimodal ferrule-top sensor designed to perform the integrated epidetection of Optical Coberence Tomognphy(OCT)depth-profiles and micron-scale indentation by all-optical detection.By scarning a sample under the probe,we can obtain structural crosse soction images and identify a region of interest in a nonhomogencous sample.Then,with the same probe and setup,we can immediately target that area with a series of spherical indentation measurements,in which the applied load is known with aμN precision,the indentation depth with sub-/m precision and a maximum contact radius of 100 pm.Thanks to the visualization of the internal structure of the sample,we can gain a better insi ght into the observed mechanical behavior.The ability to impart a small,confined load,and perfomn OCT A scans at the same time,could lead to an altemative,high transverse resolution,Optical Coherence Elastography(OCE)sensor.
基金This work is financed in part by an NWO-groot investment grant of the Netherlands Organisation for Scientific Research(NWO)and Laserlab Europe(JRA Bioptichal)SW acknowledges support from NWO Veni grant 680-47-402.
文摘Lensless imaging is an approach to microscopy in which a high-resolution image of an object is reconstructed from one or more measured diffraction patterns,providing a solution in situations where the use of imaging optics is not possible.However,current lensless imaging methods are typically limited by the need for a light source with a narrow,stable and accurately known spectrum.We have developed a general approach to lensless imaging without spectral bandwidth limitations or sample requirements.We use two time-delayed coherent light pulses and show that scanning the pulse-to-pulse time delay allows the reconstruction of diffraction-limited images for all the spectral components in the pulse.In addition,we introduce an iterative phase retrieval algorithm that uses these spectrally resolved Fresnel diffraction patterns to obtain high-resolution images of complex extended objects.We demonstrate this two-pulse imaging method with octave-spanning visible light sources,in both transmission and reflection geometries,and with broadband extreme-ultraviolet radiation from a high-harmonic generation source.Our approach enables effective use of low-flux ultra-broadband sources,such as table-top high-harmonic generation systems,for high-resolution imaging.
