In a recent study published in Nature,Delaunay and colleagues demonstrate that tRNA modifications in mitochondria have the potential to affect the synthesis of mitochondrial proteins involved in oxidative phosphorylat...In a recent study published in Nature,Delaunay and colleagues demonstrate that tRNA modifications in mitochondria have the potential to affect the synthesis of mitochondrial proteins involved in oxidative phosphorylation(OXPHOS),which drives the invasive spread of cancer cells.The inhibition of one particular RNA-modifying enzyme was sufficient to prevent the cancer cell invasion and dissemination.展开更多
基金DFG grant to A.V.(VI 562/7-1 and VI 562/10-1)M.L.is funded by T2EVOLVE,an Innovative Medicines Initiative 2 Joint Undertaking(grant agreement number 116026)This Joint Undertaking receives support from the European Union’s Horizon 2020 Research and Innovation program and European Federation of Pharmaceutical Industries and Associations(EFPIA).
文摘In a recent study published in Nature,Delaunay and colleagues demonstrate that tRNA modifications in mitochondria have the potential to affect the synthesis of mitochondrial proteins involved in oxidative phosphorylation(OXPHOS),which drives the invasive spread of cancer cells.The inhibition of one particular RNA-modifying enzyme was sufficient to prevent the cancer cell invasion and dissemination.
