This study was performed to determine the relationships between chronic pain and anatomic changes that may occur in the body.Autopsies were performed on fatalities that required death investigation in Linn County,IA,o...This study was performed to determine the relationships between chronic pain and anatomic changes that may occur in the body.Autopsies were performed on fatalities that required death investigation in Linn County,IA,or adjacent and nearby areas.Persons with chronic pain were older than the control population at the time of death.Diabetes,hypertension and depression were more common in persons with chronic pain.Certain causes of death may also have been related to chronic pain.The heart,lungs,liver,spleen and kidneys were significantly heavier in persons with chronic pain;emphysema and pleural and abdominal adhesions were more common in persons with chronic pain.There appear to have been diffuse changes in the body related to chronic pain.These changes may have been mediated by a number of systemic mechanisms that are involved with chronic pain,including cardiovascular activity,the immune system,the neuroendocrine system and others.展开更多
In some cases of fatalities involving opioid use,the concentrations of detected opioids are not in the toxic range.Immune reactions can be triggered by opioid use,suggesting that immune response may be a factor in the...In some cases of fatalities involving opioid use,the concentrations of detected opioids are not in the toxic range.Immune reactions can be triggered by opioid use,suggesting that immune response may be a factor in these cases.Autopsy cases from 2002–2012 were reviewed.Persons with physical,microscopic or serum evidence of allergic reactions and opioid use at autopsy were compared to persons who used opioids but had no such signs.Overall,49 persons were identified who had used opioids,of which five had evidence of immune response.A medical history of asthma was significantly more common in persons with signs of immune response(P=0.0244)and fatality(P=0.0085)compared to normals.A history of asthma is suggestive of susceptibility to immunologic reactions to opioids,and correlates strongly with the cause of death.展开更多
文摘This study was performed to determine the relationships between chronic pain and anatomic changes that may occur in the body.Autopsies were performed on fatalities that required death investigation in Linn County,IA,or adjacent and nearby areas.Persons with chronic pain were older than the control population at the time of death.Diabetes,hypertension and depression were more common in persons with chronic pain.Certain causes of death may also have been related to chronic pain.The heart,lungs,liver,spleen and kidneys were significantly heavier in persons with chronic pain;emphysema and pleural and abdominal adhesions were more common in persons with chronic pain.There appear to have been diffuse changes in the body related to chronic pain.These changes may have been mediated by a number of systemic mechanisms that are involved with chronic pain,including cardiovascular activity,the immune system,the neuroendocrine system and others.
文摘In some cases of fatalities involving opioid use,the concentrations of detected opioids are not in the toxic range.Immune reactions can be triggered by opioid use,suggesting that immune response may be a factor in these cases.Autopsy cases from 2002–2012 were reviewed.Persons with physical,microscopic or serum evidence of allergic reactions and opioid use at autopsy were compared to persons who used opioids but had no such signs.Overall,49 persons were identified who had used opioids,of which five had evidence of immune response.A medical history of asthma was significantly more common in persons with signs of immune response(P=0.0244)and fatality(P=0.0085)compared to normals.A history of asthma is suggestive of susceptibility to immunologic reactions to opioids,and correlates strongly with the cause of death.
