Spontaneous metastatic clostridial myonecrosis is a rare condition caused by Clostridium septicum.The underlying lesion is usually either a colonic neoplasm or leukemia.The authors reported a 67-year-old female who pr...Spontaneous metastatic clostridial myonecrosis is a rare condition caused by Clostridium septicum.The underlying lesion is usually either a colonic neoplasm or leukemia.The authors reported a 67-year-old female who presented with acute abdomen secondary to a perforated sigmoid cancer and who developed gas gangrene in her right leg.Unfortunately,despite all resuscitative measures,she died.The authors reviewed the literature;the diagnosis of metastatic myonecrosis was based on a high index of suspicion,development of bullae containing gram-positive rods,and subcutaneous crepitus(although this was a late sign).Treatment involves aggressive fluid replacement,high doses of intravenous penicillin,high concentration of oxygen,and surgical debridement,and/or amputation.The mortality remains very high,despite all the above measures.展开更多
文摘Spontaneous metastatic clostridial myonecrosis is a rare condition caused by Clostridium septicum.The underlying lesion is usually either a colonic neoplasm or leukemia.The authors reported a 67-year-old female who presented with acute abdomen secondary to a perforated sigmoid cancer and who developed gas gangrene in her right leg.Unfortunately,despite all resuscitative measures,she died.The authors reviewed the literature;the diagnosis of metastatic myonecrosis was based on a high index of suspicion,development of bullae containing gram-positive rods,and subcutaneous crepitus(although this was a late sign).Treatment involves aggressive fluid replacement,high doses of intravenous penicillin,high concentration of oxygen,and surgical debridement,and/or amputation.The mortality remains very high,despite all the above measures.
