Review Present Situation and Prospects of TCM Treatment of Parkinson's Disease

Parkinson's disease (PD) is a chronic degenerative disease of the nervous system marked by tremor,muscle rigidity, hypokinesis, abnormal posture, and pathologically, selective loss of dopaminergic neurons in the substantia nigra of the midbrain and obvious decrease of dopamine content in the striatum.It is encountered mostly in the middle-aged and old persons and is one of main causes inducing their deformity. The morbidity of this disease tends to increase with gradual aging of the population. In recent years, TCM treatment of this disease has obtained gratifying achievements. A review follows.

Effects of Electroacupuncture on the Contents of NO,ET and T-AOC in the Brain Tissues of the Cerebral Hemorrhage Model Rats

In the cerebral hemorrhage model rats established by injection of collagenase and heparin into caudate nucleus, the effects of electroacupuncture (EA) on the contents of nitric oxide (NO) and endothelin (ET),and total anti-oxidation capability (T-AOC) in the brain tissues were investigated. It is found that the content of NO in the Shuigou EA group lowered, ET decreased and the T-AOC raised significantly in both the Fengfu EA group and the Shuigou EA group (all P＜0.05) as compared with the model group,indicating that acupuncture can reduce the contents of ET and NO, and increase the T-AOC in the brain tissues of the rats with cerebral hemorrhage.

Study on the combination of brief psychodynamic psychotherapy with Viagra in the treatment of non-organic ED

Background Erectile dysfunction(ED)has gradually become an important issue that seriously affects the quality of life of Chinese men.In addition to classic oral medications,psychotherapeutic interventions are increasingly being used in the treatment of ED.Aim This study aims to investigate the clinical efficacy of brief psychodynamic psychotherapy(BPP)plus Viagra in the treatment of non-organic ED.Methods We initiated this study via a controlled,prospective experimental design with initial optimal efficiency standard greater than 10%.On the standard,63 patients were enrolled who were assigned to control or treatment group.The control group(including 33 cases)received Viagra treatment for 2 months,and the treatment group(including 30 cases)was cured with BPP plus Viagra.After the treatments,the clinical efficacy was assessed using the International Erectile Function Index(IIEF-5)score,the Self-rating Anxiety Scale(SAS),Sexual Satisfaction(SS)score and Erection Hardness Score(EHS).Results In the comparison of efficacy,pretreatment and post-treatment within each group,the two groups showed improvements in IIEF,SAS scores,SS,and EHS(treatment group:PIIEF<0.001,PSAS<0.001,PSS<0.001,PEHS<0.001;control group:PIIEF<0.001,PSAS<0.001,PSS<0.001,PEHS<0.001).Furthermore,the treatment group presented better performances in IIEF(p=0.040),SAS(p=0.006),SS scores(p=0.045)and EHS(p=0.041)than the control group.Conclusion The combination of BPP with Viagra has positive effect on the treatment of non-organic ED.http://creativecommons.org/licenses/by-nc/4.0/Background Erectile dysfunction(ED)has gradually become an important issue that seriously affects the quality of life of Chinese men.In addition to classic oral medications,psychotherapeutic interventions are increasingly being used in the treatment of ED.Aim This study aims to investigate the clinical efficacy of brief psychodynamic psychotherapy(BPP)plus Viagra in the treatment of non-organic ED.Methods We initiated this study via a controlled,prospective experimental design with initial optimal efficiency standard greater than 10%.On the standard,63 patients were enrolled who were assigned to control or treatment group.The control group(including 33 cases)received Viagra treatment for 2 months,and the treatment group(including 30 cases)was cured with BPP plus Viagra.After the treatments,the clinical efficacy was assessed using the International Erectile Function Index(IIEF-5)score,the Self-rating Anxiety Scale(SAS),Sexual Satisfaction(SS)score and Erection Hardness Score(EHS).Results In the comparison of efficacy,pretreatment and post-treatment within each group,the two groups showed improvements in IIEF,SAS scores,SS,and EHS(treatment group:PIIEF<0.001,PSAS<0.001,PSS<0.001,PEHS<0.001;control group:PIIEF<0.001,PSAS<0.001,PSS<0.001,PEHS<0.001).Furthermore,the treatment group presented better performances in IIEF(p=0.040),SAS(p=0.006),SS scores(p=0.045)and EHS(p=0.041)than the control group.Conclusion The combination of BPP with Viagra has positive effect on the treatment of non-organic ED.

Progress in research of single-flavor Chinese medicine extracts in treatment of non-small cell lung cancer

Lung cancer is one of the diseases with high morbidity and mortality,and non-small cell lung cancer accounts for a large proportion of it.Traditional Chinese medicine has a long history in treating tumors.More and more researchers have paid more attention to it.At present,many studies have proved that traditional Chinese medicine extracts such as astragalus,turmeric,ginseng,coix seed,and gallbladder can inhibit tumor cell proliferation,and have synergistic effects when used in combination with radiotherapy and chemotherapy Its mechanism of action is mostly related to regulating the cell cycle,inhibiting the expression of cancer-related genes,and inducing apoptosis.It is believed that with the development of purification technology,Chinese medicine extracts will play a greater role.

Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis

Rheumatoid arthritis(RA)is a chronic inflammatory autoimmune disease.It is known that aucubin(AU)exerts anti-inflammatory activity,but its effects and mechanisms in RA are unclear.This study investigated the anti-inflammatory effects and mechanisms of AU in vivo and in vitro.Human fibroblast-like synoviocyte cells from patients with RA(HFLS-RA),RAW264.7 cells,and MC3T3-E1 cells were used to evaluate the effects of AU on migration,invasion,apoptosis,osteoclast differentiation and production.Immunofluorescence was used to observe nuclear translocation of nuclear factor(NF)-/cB,the double luciferase reporter gene method was used to observe NF-/cB-p65 activity in AU-treated MC3T3-E1 cells.RT-qPCR was used to measure expression of bone metabolism and inflammation-related genes,and western blot was used to measure bone metabolism and NF-a:B protein expression levels.Collagen-induced arthritis(CIA)rat model was used for pharmacodynamics study.Arthritis indexes were measured in the ankle and knee,histological staining and Micro-computed tomography were performed on the ankle joints.Also,inflammatory factor gene expression and the levels of NF-/cB-related proteins were detected as in vitro.AU effectively inhibited HFLS-RA cell migration and invasion,promoted apoptosis,and inhibited RAW264.7 cell differentiation into osteoclasts,as well as inhibited NF-/cB-p65 activity in MC3T3-E1 cells.Notably,AU significantly reduced the gene expression levels of three cell-related inflammatory factors and bone metabolism factors,effectively inhibited the expression of p-lKKafi,p-lA:Ba,and p-p65 proteins.In vivo,AU relieved joint inflammation,reduced related inflammatory factors,and inhibited NF-/cB signaling.It could be used to treat RA-related synovial inflammation and bone destruction through the NF-/cB pathway.

Is the transperineal ultrasonography approach effective for the diagnosis of rectocele?

Background Transperineal ultrasonography has been used as a diagnostic imaging modality for rectocele for many years.However,the consistency of ultrasonography and defecography in evaluating the severity of rectocele was not satisfactory.This study aimed to evaluate the agreement in the measurement of rectocele parameters between the two methods in different positions and provide clinical implications for the diagnosis of rectocele.Methods In this pilot study,participants were recruited in an outpatient clinic of a tertiary hospital between December 2017 and December 2019.All participants separately underwent defecation proctography at sitting and squatting positions,and undertook transperineal ultrasonography at left lateral,sitting,and squatting positions.The consistency of ultrasonography and defecography was evaluated.Results Thirty female volunteers with rectocele were included in this study.The degree of anorectal angle was significantly larger at rest and during contraction,maximal Valsalva,and evacuation;the depth of the rectocele was significantly deeper during maximal Valsalva and evacuation;and the length of the perineumdescending was significantly longer during contraction and maximal Valsalva in using squatting position compared to the sitting position when performing the defecation proctography.The degree of anorectal angle,the depth of rectocele,the area of levator hiatus,and the volume of the rectocele were significantly different in using squatting,sitting,and left lateral positions when performing the transperineal ultrasonography.Bland-Altman semi-quantitative plots showed good consistency in the measurement of the anorectal angle and the depth of the rectocele between proctography and ultrasonography in both sitting and squatting positions.Conclusions The findings of our study may be considered as the preliminary evidence to support the use of transperineal ultrasonography with sitting and squatting positions as the imaging test of choice for evaluating patients with rectocele.

Manipulation Study on Spleen-stomach Deficiency Type of Child Anorexia Treated by Tuina

A By summarizing and observing the clinical treatment of spleen-stomach type of child anorexia by tuina, the author found that the following manipulation had a main effect： kneading Banmen, rubbing the abdomen, kneading Zhongwan（CV 12）, pinching the spine and kneading Zusanli（ST 36）.

Effect of Acupuncture on Serum SOD and MDA of Rats in Menopause

Objective： To investigate the effect of acupuncture on serum superoxide dismutase（SOD） and malondialdehyde（MDA） of rats in menopause. Methods： Female rats in menopause were randomly allocated into acupuncture, drugs and control groups, which were treated with acupuncture, Gengnian＇an Tablet, and nothing, respectively. In addition, some young female rats were used as control. After 17-day treatments, serum SOD and MDA were measured with biochemical methods. Results： Compared with the young rats, rats in menopause had lower contents of serum SOD（P〈0.01）, and higher contents of MDA（P〈0.01）. After acupuncture treatment, the contents of serum SOD increased（P〈0.05）, and MDA decreased（P〈0.05）. Conclusion： Acupuncture could increase the serum SOD contents and decrease the serum MDA contents of rats in menopause.

Professor YU Yun′s Experience in Treating Tumor by Pulse-feeling and Acupuncture

Professor YU Yun was born in Suzhou city, Jiangsu province in 1940. After graduation from Xuzhou Medical College in 1964, professor YU has been engaged himself in integrative Chinese ＆ western medcine practice in Shanghai Tumor Hospital. In the middle 1980s, he was invited to Spain for traditional Chinese medicine research.

Can transcutaneous perianal ultrasonography be the first-line diagnostic instrument for evaluating pediatric perianal fistulas?

Background:Pediatric perianal fistula is a common disorder.It is more difficult to detect the fistula tract and internal opening(IO)in children than in adults.This study aimed to evaluate the clinical diagnostic value of transcutaneous perianal ultrasound for children with perianal fistula.Methods:A retrospective review was conducted by analysing the preoperative transcutaneous perianal ultrasound and intraoperative exploration results of 203 consecutive patients who were<3 years old and diagnosed with perianal fistula.Analyses were conducted to evaluate the accuracy and consistency of utilizing the transcutaneous perianal ultrasound in the diagnosis of the complexity and location of the IO of perianal fistulas.Results:Compared with intraoperative exploration,the preoperative transcutaneous perianal ultrasonography has almost perfect agreement(Kappa=0.881,P<0.001)in the diagnosis of fistula tract complexity and IO with a sensitivity of 92%and a specificity of 97%.In addition,both intraoperative exploration and transcutaneous perianal ultrasound diagnosis showed high consistency in the identification of the IO of perianal fistulas(QuadrantⅠKappa=0.831,QuadrantⅡKappa=0.773,QuadrantⅢKappa=0.735,QuadrantⅣKappa=0.802,all P<0.01).The IOs were mainly distributed in QuadrantsⅣandⅡin both simple and complex fistulas.Conclusions:Transcutaneous perianal ultrasound,as a non-invasive and simple imaging technique,showed high accuracy in the diagnosis and identification of the fistula classification and IO location.It could be considered a first-line diagnostic instrument for evaluating perianal fistulas among children.