The antiphospholipid syndrome(APS)is a multi-systemic disease being characterized by the presence of antiphospholipid antibodies that involves both arterial and venous systems resulting in arterial or venous thrombosi...The antiphospholipid syndrome(APS)is a multi-systemic disease being characterized by the presence of antiphospholipid antibodies that involves both arterial and venous systems resulting in arterial or venous thrombosis,fetal loss,thrombocytopenia,leg ulcers,livedo reticularis,chorea,and migraine.We document a previously unreported case of a 37-year-old female in whom APS was first manifested by infarction and cecal perforation following cesarean section.At laparotomy the underlying cause of colonic perforation was not clear and after resection of the affected bowel an ileo-colostomy was performed.The diagnosis of APS was established during post-operative hospital stay and the patient was commenced on warfarin.Eventually,she made a full recovery and had her stoma reversed after 4 mo.Pregnancy poses an increased risk of complications in women with APS and requires a more aggressive approach to the obstetric care.This should include full anticoagulation in the puerperium and frequent doppler ultrasound monitoring of uterine and umbilical arteries to detect complications such as preeclampsia and placental insufficiency.展开更多
<span style="font-family:Verdana;"><strong>Subject:</strong> SLE is an autoimmune disease with skin, joint, renal, cardiovascular, and nervous manifestations. The disease is classified as a...<span style="font-family:Verdana;"><strong>Subject:</strong> SLE is an autoimmune disease with skin, joint, renal, cardiovascular, and nervous manifestations. The disease is classified as an immune complex-mediated disease and is characterized by the production of various autoantibodies. Until now, more than 100 autoantibodies have been identified. <strong>Patients and methods:</strong> This study was performed on 200 SLE patients. All of them were females and their ages ranged from 20 to 49 years. All participants in this study were subjected to physical examination, thorough history taking including age, sex, age of onset, duration of SLE disease, family history, and SLEDAI. Laboratory investigations included: CBC, ESR, liver function tests, renal function tests, ANA, Anti-dsDNA, CRP, Complements C3, C4, and Anti-NCS. <strong>Results:</strong> There was a highly significant inverse correlation between anti-NCS antibodies and Hb level, a significant direct correlation between anti-NCS antibodies and 24hr proteinuria, a significant inverse correlation between anti-NCS antibodies and complements (C3 and C4), a significant correlation between anti-NCS antibodies and anti dsDNA antibodies, a significant correlation between anti-NCS and disease activity, SLEDAI, and renal affection. <strong>Conclusion:</strong> Anti-NCS antibody can be a useful tool in the diagnosis of SLE especially in patients who are negative for anti-ds DNA antibodies.</span>展开更多
文摘The antiphospholipid syndrome(APS)is a multi-systemic disease being characterized by the presence of antiphospholipid antibodies that involves both arterial and venous systems resulting in arterial or venous thrombosis,fetal loss,thrombocytopenia,leg ulcers,livedo reticularis,chorea,and migraine.We document a previously unreported case of a 37-year-old female in whom APS was first manifested by infarction and cecal perforation following cesarean section.At laparotomy the underlying cause of colonic perforation was not clear and after resection of the affected bowel an ileo-colostomy was performed.The diagnosis of APS was established during post-operative hospital stay and the patient was commenced on warfarin.Eventually,she made a full recovery and had her stoma reversed after 4 mo.Pregnancy poses an increased risk of complications in women with APS and requires a more aggressive approach to the obstetric care.This should include full anticoagulation in the puerperium and frequent doppler ultrasound monitoring of uterine and umbilical arteries to detect complications such as preeclampsia and placental insufficiency.
文摘<span style="font-family:Verdana;"><strong>Subject:</strong> SLE is an autoimmune disease with skin, joint, renal, cardiovascular, and nervous manifestations. The disease is classified as an immune complex-mediated disease and is characterized by the production of various autoantibodies. Until now, more than 100 autoantibodies have been identified. <strong>Patients and methods:</strong> This study was performed on 200 SLE patients. All of them were females and their ages ranged from 20 to 49 years. All participants in this study were subjected to physical examination, thorough history taking including age, sex, age of onset, duration of SLE disease, family history, and SLEDAI. Laboratory investigations included: CBC, ESR, liver function tests, renal function tests, ANA, Anti-dsDNA, CRP, Complements C3, C4, and Anti-NCS. <strong>Results:</strong> There was a highly significant inverse correlation between anti-NCS antibodies and Hb level, a significant direct correlation between anti-NCS antibodies and 24hr proteinuria, a significant inverse correlation between anti-NCS antibodies and complements (C3 and C4), a significant correlation between anti-NCS antibodies and anti dsDNA antibodies, a significant correlation between anti-NCS and disease activity, SLEDAI, and renal affection. <strong>Conclusion:</strong> Anti-NCS antibody can be a useful tool in the diagnosis of SLE especially in patients who are negative for anti-ds DNA antibodies.</span>
