目的采用脑磁图(magnetoencephalography,MEG)的等价电流偶极子定位法(Equivalent current dipole,ECD)和合成孔径磁场定位法(SAM Synthetic Aperture Magnetometry,SAM)定位母语为汉语的健康自愿者的语言中枢,探讨汉字的语言处理过程...目的采用脑磁图(magnetoencephalography,MEG)的等价电流偶极子定位法(Equivalent current dipole,ECD)和合成孔径磁场定位法(SAM Synthetic Aperture Magnetometry,SAM)定位母语为汉语的健康自愿者的语言中枢,探讨汉字的语言处理过程。方法对10例母语为汉语的健康受试者给予默读真词、假词的语言任务刺激,记录刺激后产生的诱发磁场,将采集的数据与MRI叠加获得磁源性影像(MSI Magnetic source imaging)语言功能区定位。用同样的方法对4例胶质瘤患者进行术前语言功能区定位,术中皮层电刺激所定位语言功能区,明确是否产生言语障碍。结果所有受试者真词、假词均在双侧大脑半球诱发出明显的晚期磁反应波,左侧大脑半球磁反应波分化较右侧大脑半球好,Broca区位于额下同后部,Wernicke区位于颞中回、颞上回、缘上回,Wernicke区先于Broca区出现。胶质瘤患者术中电刺激所定位的Broca区、Wernicke区均产生言语障碍。结论母语为汉语的正常人的Broca区与Wernicke区与经典的语言中枢基本相符,MEG定位语言中枢的技术是可行的。展开更多
Studies in animal models of epilepsy and pre-surgical patients have unanimously found a strong correlation between high-frequency oscillations(HFOs,>80 Hz)and the epileptogenic zone,suggesting that HFOs can be a po...Studies in animal models of epilepsy and pre-surgical patients have unanimously found a strong correlation between high-frequency oscillations(HFOs,>80 Hz)and the epileptogenic zone,suggesting that HFOs can be a potential biomarker of epileptogenicity and epileptogenesis.This consensus includes the definition and standard detection techniques of HFOs,the localizing value of pathological HFOs for epileptic foci,and different ways to distinguish physiological from epileptic HFOs.The latest clinical applications of HFOs in epilepsy and the related findings are also discussed.HFOs will advance our understanding of the pathophysiology of epilepsy.展开更多
文摘目的采用脑磁图(magnetoencephalography,MEG)的等价电流偶极子定位法(Equivalent current dipole,ECD)和合成孔径磁场定位法(SAM Synthetic Aperture Magnetometry,SAM)定位母语为汉语的健康自愿者的语言中枢,探讨汉字的语言处理过程。方法对10例母语为汉语的健康受试者给予默读真词、假词的语言任务刺激,记录刺激后产生的诱发磁场,将采集的数据与MRI叠加获得磁源性影像(MSI Magnetic source imaging)语言功能区定位。用同样的方法对4例胶质瘤患者进行术前语言功能区定位,术中皮层电刺激所定位语言功能区,明确是否产生言语障碍。结果所有受试者真词、假词均在双侧大脑半球诱发出明显的晚期磁反应波,左侧大脑半球磁反应波分化较右侧大脑半球好,Broca区位于额下同后部,Wernicke区位于颞中回、颞上回、缘上回,Wernicke区先于Broca区出现。胶质瘤患者术中电刺激所定位的Broca区、Wernicke区均产生言语障碍。结论母语为汉语的正常人的Broca区与Wernicke区与经典的语言中枢基本相符,MEG定位语言中枢的技术是可行的。
基金the National Key R&D Program(No.2018YFC1314500)the National Natural Science Foundation of China(No.81701297,81801124).
文摘Studies in animal models of epilepsy and pre-surgical patients have unanimously found a strong correlation between high-frequency oscillations(HFOs,>80 Hz)and the epileptogenic zone,suggesting that HFOs can be a potential biomarker of epileptogenicity and epileptogenesis.This consensus includes the definition and standard detection techniques of HFOs,the localizing value of pathological HFOs for epileptic foci,and different ways to distinguish physiological from epileptic HFOs.The latest clinical applications of HFOs in epilepsy and the related findings are also discussed.HFOs will advance our understanding of the pathophysiology of epilepsy.
