When Does Sora Show:The Beginning of TAO to Imaginative Intelligence and Scenarios Engineering

DURING our discussion at workshops for writing“What Does ChatGPT Say:The DAO from Algorithmic Intelligence to Linguistic Intelligence”[1],we had expected the next milestone for Artificial Intelligence(AI)would be in the direction of Imaginative Intelligence(II),i.e.,something similar to automatic wordsto-videos generation or intelligent digital movies/theater technology that could be used for conducting new“Artificiofactual Experiments”[2]to replace conventional“Counterfactual Experiments”in scientific research and technical development for both natural and social studies[2]-[6].Now we have OpenAI’s Sora,so soon,but this is not the final,actually far away,and it is just the beginning.

Recent geomagnetic storms observed by Macao Science Satellite-1

Geomagnetic storms are rapid disturbances of the Earth’s magnetosphere.They are related to many geophysical phenomena and have large influences on human activities.Observing and studying geomagnetic storms is thus of great significance to both scientific research and geomagnetic hazards prevention.The Macao Science Satellite-1(MSS-1)project includes two high-precision Chinese geomagnetic satellites successfully launched on May 21,2023.The main purpose of MSS-1 is to accurately measure the Earth’s magnetic field.Here,we analyze early MSS-1 geomagnetic field measurements and report observations of two recent geomagnetic storms that occurred on March 24,2024 and May 11,2024.We also calculate the related geoelectric fields as an initial step towards a quantitative assessment of geomagnetic hazards.

A Random Fusion of Mix 3D and Polar Mix to Improve Semantic Segmentation Performance in 3D Lidar Point Cloud

This paper focuses on the effective utilization of data augmentation techniques for 3Dlidar point clouds to enhance the performance of neural network models.These point clouds,which represent spatial information through a collection of 3D coordinates,have found wide-ranging applications.Data augmentation has emerged as a potent solution to the challenges posed by limited labeled data and the need to enhance model generalization capabilities.Much of the existing research is devoted to crafting novel data augmentation methods specifically for 3D lidar point clouds.However,there has been a lack of focus on making the most of the numerous existing augmentation techniques.Addressing this deficiency,this research investigates the possibility of combining two fundamental data augmentation strategies.The paper introduces PolarMix andMix3D,two commonly employed augmentation techniques,and presents a new approach,named RandomFusion.Instead of using a fixed or predetermined combination of augmentation methods,RandomFusion randomly chooses one method from a pool of options for each instance or sample.This innovative data augmentation technique randomly augments each point in the point cloud with either PolarMix or Mix3D.The crux of this strategy is the random choice between PolarMix and Mix3Dfor the augmentation of each point within the point cloud data set.The results of the experiments conducted validate the efficacy of the RandomFusion strategy in enhancing the performance of neural network models for 3D lidar point cloud semantic segmentation tasks.This is achieved without compromising computational efficiency.By examining the potential of merging different augmentation techniques,the research contributes significantly to a more comprehensive understanding of how to utilize existing augmentation methods for 3D lidar point clouds.RandomFusion data augmentation technique offers a simple yet effective method to leverage the diversity of augmentation techniques and boost the robustness of models.The insights gained from this research can pave the way for future work aimed at developing more advanced and efficient data augmentation strategies for 3D lidar point cloud analysis.

Summer Atmospheric Water Cycle under the Transition Influence of the Westerly and Summer Monsoon over the Yarlung Zangbo River Basin in the Southern Tibetan Plateau

This study compares the summer atmospheric water cycle,including moisture sources and consumption,in the upstream,midstream,and downstream regions of the Yarlung Zangbo River Basin in the southern Tibetan Plateau.The evolutions of moisture properties under the influence of the westerly and summer southerly monsoon are examined using 5-yr multi-source measurements and ERA5 reanalysis data.Note that moisture consumption in this study is associated with clouds,precipitation,and diabatic heating.Compared to the midstream and downstream regions,the upstream region has less moisture,clouds,and precipitation,where the moisture is brought by the westerly.In early August,the vertical wet advection over this region becomes enhanced and generates more high clouds and precipitation.The midstream region has moisture carried by the westerly in June and by the southerly monsoon from July to August.The higher vertical wet advection maximum here forms more high clouds,with a precipitation peak in early July.The downstream region is mainly affected by the southerly-driven wet advection.The rich moisture and strong vertical wet advection here produce the most clouds and precipitation among the three regions,with a precipitation peak in late June.The height of the maximum moisture condensation is different between the midstream region(325 hPa)and the other two regions(375 hPa),due to the higher upward motion maximum in the midstream region.The diabatic heating structures show that stratiform clouds dominate the upstream region,stratiform clouds and deep convection co-exist in the midstream region,and deep convection systems characterize the downstream region.

Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease

Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer’s disease.Citri Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases,including Parkinson’s and Huntington’s diseases,however,the effect of Citri Reticulatae Semen on Alzheimer’s disease remains unelucidated.In the current study,the anti-apoptotic and autophagic roles of Citri Reticulatae Semen extract on amyloid-beta-induced apoptosis in PC12 cells were first investigated.Citri Reticulatae Semen extract protected PC12 cells from amyloid-beta-induced apoptosis by attenuating the Bax/Bcl-2 ratio via activation of autophagy.In addition,Citri Reticulatae Semen extract was confirmed to bind amyloid-beta as revealed by biolayer interferometry in vitro,and suppress amyloid-beta-induced pathology such as paralysis,in a transgenic Caenorhabditis elegans in vivo model.Moreover,genetically defective Caenorhabditis elegans further confirmed that the neuroprotective effect of Citri Reticulatae Semen extract was autophagy-dependent.Most importantly,Citri Reticulatae Semen extract was confirmed to improve cognitive impairment,neuronal injury and amyloid-beta burden in 3×Tg Alzheimer’s disease mice.As revealed by both in vitro and in vivo models,these results suggest that Citri Reticulatae Semen extract is a potential natural therapeutic agent for Alzheimer’s disease via its neuroprotective autophagic effects.

Gastrointestinal manifestations of critical ill heatstroke patients and their associations with outcomes:A multicentre,retrospective,observational study

BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is unknown.This study aimed to assess the incidence of GI symptoms associated with heatstroke and its impact on outcomes.AIM To assess the incidence of GI symptoms associated with heatstroke and its impact on outcomes.METHODS Patients admitted to the intensive care unit(ICU)due to heatstroke were included from 83 centres.Patient history,laboratory results,and clinically relevant outcomes were recorded at ICU admission and daily until up to day 15,ICU discharge,or death.GI symptoms,including nausea/vomiting,diarrhoea,flatulence,and bloody stools,were recorded.The characteristics of patients with heatstroke concomitant with GI symptoms were described.Multivariable regression analyses were performed to determine significant predictors of GI symptoms.RESULTS A total of 713 patients were included in the final analysis,of whom 132(18.5%)patients had at least one GI symptom during their ICU stay,while 26(3.6%)suffered from more than one symptom.Patients with GI symptoms had a significantly higher ICU stay compared with those without.The mortality of patients who had two or more GI symptoms simultaneously was significantly higher than that in those with one GI symptom.Multivariable logistic regression analysis revealed that older patients with a lower GCS score on admission were more likely to experience GI symptoms.CONCLUSION The GI manifestations of heatstroke are common and appear to impact clinically relevant hospitalization outcomes.

The Journey/DAO/TAO of Embodied Intelligence: From Large Models to Foundation Intelligence and Parallel Intelligence

THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to possess a physical“body”to transition from the virtual world to the real world and evolve through interaction with the real environments.In this context,“embodied intelligence”has sparked a new wave of research and technology,leading AI beyond the digital realm into a new paradigm that can actively act and perceive in a physical environment through tangible entities such as robots and automated devices[5].

The evolution and significance of medicine and food homology

Historical insights into medicine and food homology(MFH)Evolution of the MFH theory MFH,a basic concept in traditional Chinese medicine(TCM),suggests that many materials function as both food and medicine,providing nourishment and simultaneously treating ailments.This concept has evolved significantly throughout TCM history^([1]).Integral to this evolution was the discovery of certain materials with dual purposes during early searches for food.These materials not only offer sustenance and nutrition but are also capable of treating simple illnesses^([2]).

Design of the solar X-ray detector for the Macao Science Satellite-1B

The solar X-ray detector(SXD)onboard the Macao Science Satellite-1B was designed to monitor solar flare bursts and to study the solar activity in the 25th solar cycle.The SXD includes two parts:a soft X-ray detection unit and a hard X-ray detection unit.Both the soft X-ray detection unit and the hard X-ray detection unit include two collimators,two X-ray detectors(a silicon drift detector and a cadmium-zinc-telluride detector),and a processing circuit.Compared with similar instruments,the energy range of the SXD is wider(1–600 ke V)and the energy resolution is better(150 e V at 5.9 ke V,12%at 59.5 ke V,and 3%at 662 keV).

Surgical treatment of left-sided renal carcinoma with grade II inferior vena cava tumour thrombus: a report and review of the literature

The surgical removal of renal cancer,along with the thrombectomy of the inferior vena cava tumour thrombus,represents a remarkable milestone in urological surgery.This procedure is not only technically demanding but also requires a high level of surgical expertise.Managing renal cancer combined with a vena cava tumour thrombus poses significant challenges,especially when dealing with combined grade Ⅱ-Ⅳ inferior vena cava tumour thrombus.The complexity of these cases is further exacerbated by the delicate anatomical structures involved and the need to preserve critical vessels while effectively removing the tumour.The Upper Urethral Tumour Treatment Centre of Weifang People's Hospital successfully treated a challenging case of left renal tumour combined with grade II inferior vena cava tumour thrombus.The surgical team,led by experienced urological surgeons,meticulously planned and executed the procedure,ensuring minimal trauma to the patient and complete removal of the tumour.This achievement not only demonstrates the hospital's commitment to providing state-of-the-art surgical care but also highlights the importance of continued research and training in urological oncology.The successful outcome of this case is a testament to the expertise and dedication of the medical team and offers hope to patients facing similar complex surgical challenges.

Efficiency and safety of Tripterygium Wilfordii Hook F for IgA nephropathy: an update systematic review and meta-analysis

Background:Immunoglobulin A Nephropathy(IgAN)currently stands as the most prevalent primary chronic glomerular disease worldwide.The latest guidelines recommend the application of renin-angiotensin system inhibitors(RASi)in conjunction with corticosteroids for the treatment of IgAN patients exhibiting persistent proteinuria of≥1 g/d.However,numerous randomized controlled trials(RCTs)have revealed a heightened risk of adverse events associated with corticosteroid treatment.Multi-glycoside of Tripterygium wilfordii Hook.f.(GTW),a traditional Chinese medicine(TCM),has been employed in the treatment of Chronic Kidney Disease(CKD)for an extensive period.Recent years have witnessed an increasing number of RCTs providing evidence supporting the effectiveness of GTW therapy in IgAN.Despite this,there remains a paucity of systematic reviews on the application of GTW therapy for IgAN.Consequently,this study undertakes a systematic review to assess the clinical efficacy and safety of GTW therapy,aiming to elucidate the role of GTW therapy in the treatment of IgAN.Methods:To collect relative information of randomized controlled trials(RCTs)of GTW in the treatment of IgAN,we searched for theses and dissertations publicized before April 10,2023,in PubMed,Embase,the Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang Data knowledge service platform(Wanfang Data),Chinese Scientific Journal Database(VIP),and Clinical Trial.The language limitation is English and Chinese.Independently,two reviewers performed literature screening,data extraction,and quality evaluation,and the meta-analysis was carried out with RevMan 5.4 and StataSE 15.0 software.Results:21 RCTs involving 1,405 Chinese patients were included.Compared to ACEI/ARB alone or in combination,GTW with RASi or alone reduced 24 h-Upro,ALB,Scr,GFR,BUN,CD4+,VEGF,ET-1,and improved clinical efficacy.However,no associations were found for TC,Ccr,and adverse events due to limited literature.Conclusion:This study highlights that Multi-glycoside of Tripterygium wilfordii Hook.f.(GTW)exhibits potential in safeguarding renal function and preserving the integrity of the basement membrane in patients with Immunoglobulin A Nephropathy(IgAN).Consequently,GTW emerges as a promising therapeutic option for individuals with IgAN.Nevertheless,it is crucial to acknowledge the limitations stemming from insufficient methodology and a small sample size,which currently obscure the relationships between certain clinical variables,such as total cholesterol(TC)and creatinine clearance(Ccr).Therefore,the substantiation of our findings necessitates more rigorous and expansive trials to enhance the robustness and generalizability of the results.

Study on the estimation of Euler angles for Macao Science Satellite-1

The Euler angle estimation is a calibration method for vector data measured by the magnetometer on a satellite.It is used to find the relative rotation between the coordinate system of the magnetometer and the satellite(usually determined by Star Imagers).Before launch of the low-orbit,low-inclination Macao Science Satellite-1(known as MSS-1),we simulated the estimation of Euler angles by using the magnetic measurements of the in-orbit Swarm and China Seismo-Electromagnetic Satellite(noted as CSES),with various data combinations.In this study,11 data sets were designed to analyze the estimation results for the MSS-1 orbit by using a joint estimation method of the geomagnetic field model parameters and Euler angles.For the model results,we found that all the spatial power spectral lines showed behavior consistent with that of the CHAOS-7.8 model at low degrees(corresponding to large-scale magnetic signals).The spectra of models without global data coverage deviated much more(by a maximum of~10^(4) nT^(2))from those of the CHAOS-7.8 model at higher degrees.For models with global data coverage and with various data combinations,the spectral lines were distributed similarly.Moreover,the models with accordant power spectral distributions demonstrated different Euler angle estimations.As more vector data at higher latitudes were included,the estimated Euler angles varied monotonically in all three directions.The models with vector data in the same latitude range showed similar Euler angle results,regardless of whether the poleward scalar data were included.The largest value difference was found between the models using vector data within±40°latitudes and those using vector data within±60°latitudes,which reached to~28″.Therefore,we concluded that the inversion of the spherical harmonic Gauss coefficients in our tests was mainly affected by the spatial coverage range of the data,whereas the estimation of Euler angles largely depended on the latitude range where the vector data could be obtained.These results can be used for future in-flight data testing.We expect the estimation of Euler angles to improve as other methods are adopted.

Numerical simulation of the sensor output on Macao Science Satellite-1

Macao Science Satellite-1(MSS-1)will be launched at the early of 2023 into a near-circular orbit.The mission is designed to measure the Earth’s geomagnetic field with unpreceded accuracy through a new perspective.The most important component installed on the satellite,to ensure high accuracy,is the deployable boom(Optical Bench).A Vector Field Magnetometer(VFM),an Advanced Stellar Compass(ASC),and a Couple Dark State Magnetometers(CDSM)are deployed on the deployable boom.In order to maximize the mission’s scientific output,a numerical simulator on MSS-1’s deployable boom was required to evaluate the adaptability of all devices on the deployable boom and assist the satellite’s data pre-processing.This paper first briefly describes the synthesis of the Earth’s total magnetic field and then describes the method simulating the output of scalar and vector magnetometers.Finally,the calibration method is applied to the synthetic magnetometer data to analyze the possible noise/error of the relevant instruments.Our results show that the simulator can imitate the disturbance of different noise sources or errors in the measuring system,and is especially useful for the satellite’s data processing group.

A novel geomagnetic satellite constellation:Science and applications

The European Space Agency(ESA)’s Swarm constellation of a trio of geomagnetic survey satellites in nearly circular polar orbits at altitude about 500 km was launched on 22 November 2013 and has been mapping the Earth’s global magnetic field in unprecedented details,helping scientists better understand how the geomagnetic field is generated and maintained inside the Earth’s fluid core and how the Earth’s external magnetic environment is changing.This review discusses a new novel constellation of the geomagnetic survey satellites that consists of at least four satellites:two satellites are in lower-latitude and nearly circular orbits at altitude about 450 km;two further satellites are marked by nearly polar but strongly eccentric orbits with perigee about 200 km and apogee about 5000 km.The new geomagnetic satellites are equipped with highly stable optical benches,high-precision fluxgate magnetometers and scalar magnetometers which are capable of mapping the Earth’s three-dimensional magnetic field in unprecedented accuracies and details.The new constellation will help elucidate different contributions to the measured geomagnetic field:the core dynamo field,the lithospheric magnetic field,the magnetic fields produced by currents in the ionosphere and the magnetosphere as well as by the currents coupling the ionosphere and magnetosphere,and the magnetic fields induced from the electrically conducting mantle,lithosphere and oceans.In comparison to the Swarm mission,it will provide higher-accuracy,higher-resolution and higher-dimension measurements of the geomagnetic field required for shedding new insights into the core dynamo processes and the Earth’s space magnetic systems along with a wide range of important applications.

Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism

Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well understood.Here,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery occlusion.Comprehensive proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic stroke.Moreover,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway analysis.Liquid chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic acid.Overall,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction.

N-doped graphene quantum dot-decorated N-TiO2/P-doped porous hollow g-C_(3)N_(4) nanotube composite photocatalysts for antibiotic photodegradation and H2 production

Exclusive responsiveness to ultraviolet light (~3.2 eV) and high photogenerated charge recombination rate are the two primary drawbacks of pure TiO_(2). We combined N-doped graphene quantum dots (N-GQDs), morphology regulation, and heterojunction construction strategies to synthesize N-GQD/N-doped TiO_(2)/P-doped porous hollow g-C_(3)N_(4) nanotube (PCN) composite photocatalysts (denoted as G-TPCN). The optimal sample (G-TPCN doped with 0.1wt% N-GQD, denoted as 0.1% G-TPCN) exhibits significantly enhanced photoabsorption, which is attributed to the change in bandgap caused by elemental doping (P and N), the improved light-harvesting resulting from the tube structure, and the upconversion effect of N-GQDs. In addition, the internal charge separation and transfer capability of0.1% G-TPCN are dramatically boosted, and its carrier concentration is 3.7, 2.3, and 1.9 times that of N-TiO_(2), PCN, and N-TiO_(2)/PCN(TPCN-1), respectively. This phenomenon is attributed to the formation of Z-scheme heterojunction between N-TiO_(2) and PCNs, the excellent electron conduction ability of N-GQDs, and the short transfer distance caused by the porous nanotube structure. Compared with those of N-TiO_(2), PCNs, and TPCN-1, the H2 production activity of 0.1%G-TPCN under visible light is enhanced by 12.4, 2.3, and 1.4times, respectively, and its ciprofloxacin (CIP) degradation rate is increased by 7.9, 5.7, and 2.9 times, respectively. The optimized performance benefits from excellent photoresponsiveness and improved carrier separation and migration efficiencies. Finally, the photocatalytic mechanism of 0.1% G-TPCN and five possible degradation pathways of CIP are proposed. This study clarifies the mechanism of multiple modification strategies to synergistically improve the photocatalytic performance of 0.1% G-TPCN and provides a potential strategy for rationally designing novel photocatalysts for environmental remediation and solar energy conversion.

Unfolding the structure-property relationships of Li_(2)S anchoring on two-dimensional materials with high-throughput calculations and machine learning

Lithium-sulfur(Li-S)batteries are notable for their high theoretical energy density,but the‘shuttle effect’and the limited conversion kinetics of Li-S species can downgrade their actual performance.An essential strategy is to design anchoring materials(AMs)to appropriately adsorb Li-S species.Herein,we propose a new three-procedure protocol,named InfoAd(Informative Adsorption)to evaluate the anchoring of Li_(2)S on two-dimensional(2D)materials and disclose the underlying importance of material features by combining high-throughput calculation workflow and machine learning(ML).In this paradigm,we calculate the anchoring of Li_(2)S on 12552D A_(x)B_(y)(B in the VIA/VIIA group)materials and pick out 44(un)reported nontoxic 2D binary A_(x)B_(y)AMs,in which the importance of the geometric features on the anchoring effect is revealed by ML for the first time.We develop a new Infograph model for crystals to accurately predict whether a material has a moderate binding with Li_(2)S and extend it to all 2D materials.Our InfoAd protocol elucidates the underlying structure-property relationship of Li_(2)S adsorption on 2D materials and provides a general research framework of adsorption-related materials for catalysis and energy/substance storage.

Linking atmospheric emission and deposition to accumulation of soil cadmium in the Middle-Lower Yangtze Plain,China

Cadmium(Cd)is one of the most toxic heavy metals in the environment.Atmospheric deposition has been found to be the main source of Cd pollution of soil on a large scale in China,and identification of the relationships between anthropogenic emission,atmospheric deposition,and Cd accumulation in soil is important for developing ways to mitigate Cd non-point pollution.In this study,the relationship between atmospheric emission,atmospheric deposition,and soil Cd accumulation in the Middle-Lower Yangtze Plain in China was investigated using datasets of atmospheric emission,deposition,and soil accumulation from the literatures published between 2000 and 2020.The results showed that the soil Cd accumulation rate in the study area exceeded the national average(4.0μg kg^(–1)yr^(–1))and continued to accumulate in recent decades,although the average accumulation rate decreased from 9.45μg kg^(–1)yr^(–1)(2000–2010 period)to8.86μg kg^(–1)yr^(–1)(2010–2020 period).The contribution of atmospheric deposition flux to Cd increment in the soil was in the range of 22–29%,with the atmospheric deposition flux decreasing from 0.54 mg m^(–2)yr^(–1)(2000–2010)to 0.48 mg m^(–2)yr^(–1)(2010–2020),both values being greater than the national average.Atmospheric Cd deposition and emission were highly correlated in a provincial administrative region,which is close to a ratio of 1.0.Emission factors may be in a state of dynamic change due to the influences of new Cd emission control technologies and environmental policies.As the main sources of Cd emissions,dust,and smoke emissions per ton of non-ferrous metal production decreased by 64.7%between the 2000–2010 and 2010–2020 periods.Although new environmental policies have been instigated,atmospheric emission of Cd is still excessive.It was hoped that the findings of this work would provide a scientific basis for the rational control of atmospheric emissions and Cd pollution of soil.

The behavior of a lithospheric magnetization and magnetic field model

The Earth’s“lithosphere”is its outer shell,made up of the Earth’s crust and outermost mantle.The part of the Earth’s magnetic field that originates in the lithosphere consists of a superposition of magnetic anomalies with a broad spectrum of sizes and intensities,which arise from geological and tectonic features.The lithospheric magnetic field is known from surface observations,and on larger scales from above-surface measurements.The increase in recent decades of satellites dedicated to measuring the Earth’s magnetic field has improved significantly our models of the Earth’s magnetic environment.Based on these increasing observations,a number of comprehensive field models have been constructed,some of which focus solely on the lithosphere,such as the MF model series.We present a map of lithospheric magnetic anomalies at 400 km altitude,based on a vertically integrated magnetization model.This height was chosen because it is the expected orbital altitude of the Macao Science Satellite-1(MSS-1)mission.The model presented herein indicates that the amplitude of the lithospheric anomalies at 400 km altitude is between-14.8 n T and 18.2 n T.This information is useful because it provides a reference for the lithospheric source of the Earth’s magnetic field that contributes to the magnetic measurements made from satellite instruments.The low inclination orbit of the MSS-1 mission will provide information that is sensitive to lateral variation within the lithosphere;these variations arise from plate tectonic features with longitudinal extent.In conclusion,the new MSS-1mission will provide valuable information in detecting compositional variations in the lithosphere,and in delineating large-scale geological structures.

Theanine combined with cisplatin inhibits the proliferation and metastasis of TNBC cells through Akt signaling pathway

Background:Theanine,was natural compounds,has been employed in antibacterial,antineoplastic,promotion of hair growth,therapy of poliosis,and removing pattogenic heat from the blood and toxic material from the body for centuries.However,few reports focused on the treatment by theanine combined with chemotherapy in triple negative breast cancer.Methods:Our study aimed to evaluate and compare the molecular and cellular effects of theanine in combination with cisplatin in triple negative breast cancer lines MDA-MB-231.The 50%inhibitory concentration and cell viability were determined by the cell counting kit-8 assay.Meanwhile,wound healing and transwell assays were used to evaluate the effect of theanine combination with cisplatin on triple negative breast cancer(TNBC)cell metastasis.Moreover,the label-free proteomic method was available to explore the molecular mechanism of theanine combination with cisplatin on TNBC cells.What’s more,reverse transcription-polymerase chain reaction and western blotting were carried out to evaluate the related protein and mRNA alteration in the Akt signaling pathway.Results:With theanine added,the inhibitory effect of cisplatin on cell proliferation and metastasis was significantly improved.Meanwhile,with the increase of theanine concentration,the anti-tumor effect of the combination group was also significantly improved.Afterward,label-free proteomics analysis showed that theanine combined with cisplatin could significantly activate the Akt signaling pathway,thus improving the anti-tumor effect of cisplatin.Finally,reverse transcription-polymerase chain reaction and western blotting experiment showed that the combination of cisplatin with theanine induced the greatest down-regulation of phosphorylated Akt expression.Conclusion:All in all,combining theanine with appears to be a promising strategy for the effective treatment of TNBC in the prospective application which merits further clinical investigation.