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Applications of multi-nuclear magnetic resonance spectroscopy at 7T 被引量:2
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作者 Mary C Stephenson Frances Gunner +6 位作者 Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris 《World Journal of Radiology》 CAS 2011年第4期105-113,共9页
AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.METHODS: Measurements of brain metabolites were made at both 3 and 7T using 1H MRS. Me... AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.METHODS: Measurements of brain metabolites were made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively.RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these metabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and re-feeding. Glycogen levels were significantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study.CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. 展开更多
关键词 Magnetic resonance spectroscopy 13C 1H 7 Tesla GLUTAMATE GLUTAMINE γ-aminobutyric acid
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Individualized brain mapping for navigated neuromodulation
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作者 Chaohong Gao Xia Wu +4 位作者 Xinle Cheng Kristoffer Hougaard Madsen Congying Chu Zhengyi Yang Lingzhong Fan 《Chinese Medical Journal》 SCIE CAS CSCD 2024年第5期508-523,共16页
The brain is a complex organ that requires precise mapping to understand its structure and function.Brain atlases provide a powerful tool for studying brain circuits,discovering biological markers for early diagnosis,... The brain is a complex organ that requires precise mapping to understand its structure and function.Brain atlases provide a powerful tool for studying brain circuits,discovering biological markers for early diagnosis,and developing personalized treatments for neuropsychiatric disorders.Neuromodulation techniques,such as transcranial magnetic stimulation and deep brain stimulation,have revolutionized clinical therapies for neuropsychiatric disorders.However,the lack of fine-scale brain atlases limits the precision and effectiveness of these techniques.Advances in neuroimaging and machine learning techniques have led to the emergence of stereotactic-assisted neurosurgery and navigation systems.Still,the individual variability among patients and the diversity of brain diseases make it necessary to develop personalized solutions.The article provides an overview of recent advances in individualized brain mapping and navigated neuromodulation and discusses the methodological profiles,advantages,disadvantages,and future trends of these techniques.The article concludes by posing open questions about the future development of individualized brain mapping and navigated neuromodulation. 展开更多
关键词 Brain atlas INDIVIDUALIZATION Navigated neuromodulation Multimodal magnetic resonance imaging Transcranial magnetic stimulation Deep brain stimulation
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Shared and distinct abnormalities of brain magnetization transfer ratio in schizophrenia and major depressive disorder:a comparative voxel-based meta-analysis 被引量:1
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作者 Huan Lan Xueling Suo +4 位作者 Chao Zuo Weishi Ni Song Wang Graham JKemp Qiyong Gong 《Chinese Medical Journal》 SCIE CAS CSCD 2023年第23期2824-2833,共10页
Background:Patients with schizophrenia(SCZ)and major depressive disorder(MDD)share significant clinical overlap,although it remains unknown to what extent this overlap reflects shared neural profiles.To identify the s... Background:Patients with schizophrenia(SCZ)and major depressive disorder(MDD)share significant clinical overlap,although it remains unknown to what extent this overlap reflects shared neural profiles.To identify the shared and specific abnormalities in SCZ and MDD,we performed a whole-brain voxel-based meta-analysis using magnetization transfer imaging,a technique that characterizes the macromolecular structural integrity of brain tissue in terms of the magnetization transfer ratio(MTR).Methods:A systematic search based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was conducted in PubMed,EMBASE,International Scientific Index(ISI)Web of Science,and MEDLINE for relevant studies up to March 2022.Two researchers independently screened the articles.Rigorous scrutiny and data extraction were performed for the studies that met the inclusion criteria.Voxel-wise meta-analyses were conducted using anisotropic effect size-signed differential mapping with a unified template.Meta-regression was used to explore the potential effects of demographic and clinical characteristics.Results:A total of 15 studies with 17 datasets describing 365 SCZ patients,224 MDD patients,and 550 healthy controls(HCs)were identified.The conjunction analysis showed that both disorders shared higher MTR than HC in the left cerebellum(P=0.0006)and left fusiform gyrus(P=0.0004).Additionally,SCZ patients showed disorder-specific lower MTR in the anterior cingulate/paracingulate gyrus,right superior temporal gyrus,and right superior frontal gyrus,and higher MTR in the left thalamus,precuneus/cuneus,posterior cingulate gyrus,and paracentral lobule;and MDD patients showed higher MTR in the left middle occipital region.Meta-regression showed no statistical significance in either group.Conclusions:The results revealed a structural neural basis shared between SCZ and MDD patients,emphasizing the importance of shared neural substrates across psychopathology.Meanwhile,distinct disease-specific characteristics could have implications for future differential diagnosis and targeted treatment. 展开更多
关键词 Magnetization transfer imaging Major depressive disorder META-ANALYSIS NEUROIMAGING Psychoradiology SCHIZOPHRENIA
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Pre-coronavirus disease 2019 brain structure might be associated with social anxiety alterations during the pandemic
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作者 Xun Zhang Qingyuan Li +6 位作者 Xun Yang Nanfang Pan Xueling Suo Min He Song Wang Graham JKemp Qiyong Gong 《Chinese Medical Journal》 SCIE CAS CSCD 2023年第13期1621-1623,共3页
To the Editor:As the novel coronavirus disease 2019(COVID-19)pandemic rapidly spreads around the world,it has resulted in unprecedented economic loss,social turmoil,and detrimental effects on public mental health.In p... To the Editor:As the novel coronavirus disease 2019(COVID-19)pandemic rapidly spreads around the world,it has resulted in unprecedented economic loss,social turmoil,and detrimental effects on public mental health.In particular,the implementation of disease control measures such as nationwide lockdowns,social distancing,school closures,and home quarantine has given rise to a wide range of social anxiety(SA)around the world,from nonclinical manifestations to clinical social anxiety disorder(SAD).[1]Given the potentially severe impairments from SA and the limited mental health care resources,it is vital to identify whether there are vulnerability/risk neuropsychological factors contributing to the progression of SA during the pandemic. 展开更多
关键词 alterations NATIONWIDE CLOSURE
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Altered white matter microarchitecture in Parkinson’s disease:a voxel-based meta-analysis of diffusion tensor imaging studies
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作者 Xueling Suo Du Lei +8 位作者 Wenbin Li Lei Li Jing Dai Song Wang Nannan Li Lan Cheng Rong Peng Graham J Kemp Qiyong Gong 《Frontiers of Medicine》 SCIE CAS CSCD 2021年第1期125-138,共14页
This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson’s disease(PD)reflected by fractional anisotropy(FA),addressing clinical profiles and methodology-related heterogeneit... This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson’s disease(PD)reflected by fractional anisotropy(FA),addressing clinical profiles and methodology-related heterogeneity.Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusion tensor imaging studies comparing PD with healthy controls(HC)using the anisotropic effect size–signed differential mapping.A total of 808 patients with PD and 760 HC coming from 27 databases were finally included.Subgroup analyses were conducted considering heterogeneity with respect to medication status,disease stage,analysis methods,and the number of diffusion directions in acquisition.Compared with HC,patients with PD had decreased FA in the left middle cerebellar peduncle,corpus callosum(CC),left inferior fronto-occipital fasciculus,and right inferior longitudinal fasciculus.Most of the main results remained unchanged in subgroup metaanalyses of medicated patients,early stage patients,voxel-based analysis,and acquisition with˂30 diffusion directions.The subgroup meta-analysis of medication-free patients showed FA decrease in the right olfactory cortex.The cerebellum and CC,associated with typical motor impairment,showed the most consistent FA decreases in PD.Medication status,analysis approaches,and the number of diffusion directions have an important impact on the findings,needing careful evaluation in future meta-analyses. 展开更多
关键词 Parkinson’s disease diffusion tensor imaging fractional anisotropy META-ANALYSIS anisotropic effect size-signed differential mapping
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预防和管理2型糖尿病的饮食和营养干预策略
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作者 Nita G Forouhi Anoop Misra +4 位作者 Viswanathan Mohan Roy Taylor William Yancy 黄融(译) 竹萍(校) 《英国医学杂志中文版》 2019年第9期500-506,共7页
Nita G Forouhi和同事们认为,我们可以找到预防、管理和可能缓解2型糖尿病的饮食方法基本要点。饮食因素在2型糖尿病的预防和管理中至关重要。尽管在制定循证饮食指南方面取得了进展,但争议和困惑依然存在。在本文中,我们研究了现有证据... Nita G Forouhi和同事们认为,我们可以找到预防、管理和可能缓解2型糖尿病的饮食方法基本要点。饮食因素在2型糖尿病的预防和管理中至关重要。尽管在制定循证饮食指南方面取得了进展,但争议和困惑依然存在。在本文中,我们研究了现有证据,确定2型糖尿病饮食指南中哪些领域取得了共识,哪些还存在不确定性或争议。 展开更多
关键词 2型糖尿病 饮食方法 营养干预 管理 预防 饮食因素 饮食指南
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Cortical thickness abnormalities in patients with first episode psychosis:a meta-analysis of psychoradiologic studies and replication in an independent sample
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作者 Keren Wen Youjin Zhao +9 位作者 Qiyong Gong Ziyu Zhu Qian Li Nanfang Pan Shiqin Fu Joaquim Radua Eduard Vieta Poornima Kumar Graham J.Kemp Bharat B.Biswal 《Psychoradiology》 2021年第4期185-198,共14页
Background:Abnormalities of cortical thickness(CTh)in patients with their first episode psychosis(FEP)have been frequently reported,but findings are inconsistent.Objective:To define the most consistent CTh changes in ... Background:Abnormalities of cortical thickness(CTh)in patients with their first episode psychosis(FEP)have been frequently reported,but findings are inconsistent.Objective:To define the most consistent CTh changes in patients with FEP by meta-analysis of publishedwholebrain studies.Methods:The meta-analysis used seed-based dmapping(SDM)software to obtain the most prominent regional CTh changes in FEP,and meta-regression analyses to explore the effects of demographics and clinical characteristics.The meta-analysis results were verified in an independent sample of 142 FEP patients and 142 age-and sex-matched healthy controls(HCs),using both a vertex-wise and a region of interest analysis,with multiple comparisons correction.Results:The meta-analysis identified lower CTh in the rightmiddle temporal cortex(MTC)extending to superior temporal cortex(STC),insula,and anterior cingulate cortex(ACC)in FEP compared with HCs.No significant correlations were identified between CTh alterations and demographic or clinical variables.These results were replicated in the independent dataset analysis.Conclusion:This study identifies a robust pattern of cortical abnormalities in FEP and extends understanding of gray matter abnormalities and pathological mechanisms in FEP. 展开更多
关键词 psychoradiology first episode psychosis early psychosis cortical thickness META-ANALYSIS seed-based d mapping
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