Effect of rotation in generalized thermoelastic solid under the influence of gravity with an overlying infinite thermoelastic fluid

The present problem is concerned with the study of deformation of a rotating generalized thermoelastic solid with an overlying infinite thermoelastic fluid due to different forces acting along the interface under the influence of gravity.The components of displacement,force stress,and temperature distribution are first obtained in Laplace and Fourier domains by applying integral transforms,and then obtained in the physical domain by applying a numerical inversion method.Some particular cases are also discussed in the context of the problem.The results are also presented graphically to show the effect of rotation and gravity in the medium.

Hybridization between salt resistant and salt susceptible genotypes of mungbean(Vigna radiata L.Wilczek)and purity testing of the hybrids using SSRs markers

Six cultivated and two wild genotypes of mungbean（Vigna radiata L. Wilczek） possessing variation for phenotypic and genotypic response for salt tolerance were hybridized. Hybridization results showed successful pod set and significant variations in cross-compatibility of investigated genotypes. Genotypes PLM 380 and PLM 562 showed promising combining ability with all genotypes. Results revealed significant crossing compatibility between V. radiata and V. sublobata. The cross ability ranged from 1.99 to 5.12%（average 3.08%）. Molecular analysis confirmed the hybrids purity. All F_1 seeds were bold, green/shiny green and germinated between 3 to 5 days. Hybrid plants were normal, fertile and healthier over their respective progenitors. Uniform flowering and maturity of the hybrids showed absence of any defect or alteration in plant habit and life cycle of the hybrids. The hybrid plants showed increase in yield characteristics as no. of pods, pod length, 100 seeds weight, and yield per plant. Number of pods containing F_2 seeds ranged from 5–8 per cluster. The F_2 seeds were collected and stored for further research. Present study suggests that salt resistant wild relatives or cultivars of mungbean can be explored by breeding as a source of useful traits/genes providing salt tolerance. This may help in development of best mungbean variety for saline prone areas. Micro-satellite markers linked to the trait/genes may assist breeding by early selection of the genotypes compared to the phenotypic screening.

Alteration in the expression of microRNA-21 regulated target genes:Role in breast cancer

Breast cancer,also recognized as the principal cause of cancer-related deaths among women,is the second most familiar and prevalent form of cancer.New diagnostic and prognostic biomarkers that are highly specific are urgently needed for its early prognosis.MicroRNAs(miRNAs),a class of non-coding RNAs,are known to control the biological processes involving transcription,post-transcriptional and covalent modifications,splicing,translation,cell differentiation,proliferation,apoptosis,cancer progression,and invasion.Any dysregulation in miRNA expression,demonstrating their oncogenic and tumor-suppressive functions,contributes to cancer progression.MicroRNA-21(miR-21),an‘onco-miR’in breast cancer,is involved in tumor progression and metastasis by suppressing the activity of the target gene via its interaction with the 3’UTR of the target gene.The upregulation of miR-21 is observed in many instances of breast cancer.Our review aims to summarize the current understanding of miR-21 in the regulation of important cellular functions via regulation of its target genes.We discuss its biosynthesis,oncogenic function in breast cancer,and different methods used for its detection.This will increase the current understanding of the role of miR-21 in breast cancer tumorigenesis,which will offer a perception of using miR-21 as an early detection molecular prognostic and diagnostic biomarker and as a therapeutic target in breast cancer care.

Evaluation of antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves

Background:Vitis vinifera is universally appreciated herb(especially fruit)for their delicacy,nutrition and conventional as functional food.In the present study,we evaluated anti-hypercholesterolemic potential of Vitis vinifera red leaves extract in experimental wistar male rats.Material and methods:Qualitative and quantitative phytochemical screening of vitis vinifera methanolic extract(VVME)and vitis vinifera aqueous extract aqueous(VVAE)extract was carried out to identify the phytoconstituents.The anti-hypercholesterolemic activity was evaluated by inducing hypercholesterolemia with high cholesterol diet for 21 days in experimental animals.During the experimental periods parameters like lipid profile,liver function test,atherogenic index and histopathological studies were analysed.Results:Total tannins,total flavonoids and total phenolic contents were found in major amount in VVME.The lipid levels were significantly attenuated by different doses of VVME and VVAE.Moreover,VVME was found more effective than VVAE and histopathological results confirmed the effectiveness of VVME.Conclusion:It can be concluded that anti-hypercholesterolemic efficacy of Vitis vinifera might be due to presence of active phytoconstituents and its antioxidant efficacy.

Antioxidants: Friend or foe for tuberculosis patients

Respiratory burst induced bacteria killing by oxidants are important mechanism of host defence. However, it is impaired in tuberculosis due to inhibition of respiratory burst by Mycobacterial factors. Antioxidants are compounds that cause chelation of reactive oxygen species. So, antioxidants are expected to play a negative role in the management of active tuberculosis. But, oxidative stress is a proved fact that invariably happens in tuberculosis patients which is known to cause immunosuppression. Immunosuppression in turn is expected to augment tuberculosis. Hence, antioxidant supplementation is expected to benefit tuberculosis patients by minimising oxidative stress induced immunosuppression. Therefore, the role of antioxidants in tuberculosis appears to be paradoxical and urgent. Understanding of the role of antioxidant supplementation in tuberculosis is warranted. It is in this context that we have reviewed the recent literature and addressed the problem for its solution.

miR-153 as biomarker for cancer-functional role as tumor suppressor

MicroRNA-153(miR-153),belongs toa dass of small non-coding RNA.It is a aritical regulator of gene expression at the post-transcriptional lewel which interacts with the functional mRNA at 3UTR rgion and suppresses the expression of the mRNA.More recently,it has become apparent that dhanges in the miR-153 axpression lead to invasion,metastasis,angiogenesis and various types of tumor progression.This review summarizes the connection between dysrgulation of miR-153 and various typas of cancer progression.miR-153 regulates various signaling pathways to inhibit the proliferation and induce apoptosis in the ancer cell and also show synergistic activity with anticancer drugs.In addition to this,the oncogenic bchavior of miR-153 and their use as a potential biomarker in cancer was also reviewed.

Diagnostic imaging:Morphological and eruptive disturbances in the permanent teeth

This paper reviewed the literature on newer threedimensional imaging techniques and their applications in diagnosis and treatment planning of various dental anomalies. Developmental anomalies can occur during any of the developmental stages and are manifested clinically after the tooth is fully formed. These dental anomalies may involve a single tooth, a group of teeth, or the entire dentition. Two-dimensional diagnosticimaging, including periapical, occlusal, panoramic, or cephalometric radiographs are essential in localization and management of morphological and eruptive disorders. However, due to their inherent limitations such as insufficient precision because of unusual projection errors and lack of information about spatial relationships, these methods are considered unreliable. Thus, the use of newer image acquisition techniques that allow comprehensive three dimensional imaging and visualization of dental abnormalities is highly recommended for making a confirmatory diagnosis. The significance of accurate endodontic, surgical and orthodontic treatment planning in dental abnormalities cannot be overstated as it pertains to critical anatomic landmarks such as proximity to adjacent teeth or the mandibular canal. The precise information on spatial relationships provided by multiplanar imaging helps the dental surgeon to establish more accurate diagnosis, management strategies and also increases the patient safety. This review highlights the use of high-end diagnostic imaging modalities in diagnosis of the various morphologic and eruptive dental abnormalities.

A hybrid system to predict brain stroke using a combined feature selection and classifier

Background Brain stroke is a serious health issue that requires timely and accurate prediction for effective treatment and prevention.This study described a hybrid system that used the best feature selection method and classifier to predict brain stroke.Methods The Stroke Prediction Dataset from Kaggle was used for this study.Synthetic minority over-sampling technique(SMOTE)analysis was used to accomplish class balancing.Accuracy,sensitivity,specificity,precision,and the F-Measure were the main performance parameters considered for investigation.To determine the best combination for predicting brain stroke,the performance of five classifiers,Naïve Bayes(NB),support vector machine(SVM),random forest(RF),adaptive boosting(Adaboost),and extreme gradient boosting(XGBoost),was compared along with three feature selection techniques,mutual information(MI),Pearson correlation(PC),and feature importance(FI).The performance parameters were assessed using k-fold cross-validation.Results The hybrid system proposed in this study identified a reduced set of features that were able to effectively predict brain stroke.FI provided a feature reduction ratio of 36.3%.The most successful hybrid system for predicting brain stroke used FI as the feature selection technique and RF as the classifier,achieving an accuracy of 97.17%.Conclusion The proposed system predicted brain stroke with high accuracy.These findings could be used to inform the early detection and prevention of brain stroke,allowing healthcare professionals to provide timely and targeted care to at-risk patients.

A New Exponential Fuzzy Entropy of Order-(α,β)and its Application in Multiple Attribute Decision-Making Problems

Fuzzy entropy is an important concept to measure the fuzzy information.Measure of fuzziness of a fuzzy set is the measure of its fuzziness.In the present communication,we have defined an exponential fuzzy entropy of order-(α,β).Besides establishing the validity of the proposed measure,we have also discussed some of its properties.At last,we have given the application of the proposed measure in multiple attribute decision-making problems.In this section,we have considered two cases for the weights of attributes:One is the case when weights are completely unknown to us,and the other is the case when weights are partially known to us.

Effect of Rotation Under the Influence of Gravity Due to Various Sources in a Generalized Thermoelastic Medium

The present problem is concerned with the study of deformation of a rotating generalized thermoelastic medium under the influence of gravity.The components of displacement,force stress and temperature distribution are obtained in Laplace and Fourier domain by applying integral transforms.These components are then obtained in the physical domain by applying a numerical inversion method.Some particular cases are also discussed in context of the problem.The results are also presented graphically to show the effect of rotation and gravity in the medium.