The Federal Highway Administration (FHWA) sponsored a large,multi-year project conducted by the Multidisciplinary Center for Earthquake Engineering Research (MCEER) titled'Seismic Vulnerability of New Highway Cons...The Federal Highway Administration (FHWA) sponsored a large,multi-year project conducted by the Multidisciplinary Center for Earthquake Engineering Research (MCEER) titled'Seismic Vulnerability of New Highway Construction'(MCEER Project 112),which was completed in 1998.MCEER coordinated the work of many researchers,who performed studies on the seismic design and vulnerability analysis of highway bridges,tunnels,and retaining structures. Extensive research was conducted to provide revisions and improvements to current design and detailing approaches and national design specifications for highway bridges.The program included both analytical and experimental studies,and addressed seismic hazard exposure and ground motion input for the U.S.highway system;foundation design and soil behavior: structural importance,analysis,and response:structural design issues and details;and structural design criteria.展开更多
Epicuticular wax forms the outermost protective barrier of the aerial surfaces of land plants, working in concert with other components of the plant cuticle to prevent uncontrolled loss of water and to provide protect...Epicuticular wax forms the outermost protective barrier of the aerial surfaces of land plants, working in concert with other components of the plant cuticle to prevent uncontrolled loss of water and to provide protection against an array of external environmental stress. In this study, chemically- mutagenized populations of rice (Oryza sativa L.) derived from approximately 4 750 M2 families were screened for adhesion of water droplets resulting in a wet leaf/glossy (wig) phenotype. Mutants were identified in 11 independently-derived M2 families. Scanning electron microscopy analysis confirmed the association of the wig phenotype with changes in the epicuticular wax crystals of these plants. The phenotypes of five mutants (7-17A, 26.1, 524.2, 680.2, and 843.1) were confirmed to be the result of single recessive gene mutation. Evaluation of mutants from 3 (6-1A, 7-17A, and 11-39A) of 11 M2 families revealed significant reductions (〉 50%) in surface wax content and increases in cuticle membrane permeability.展开更多
Three hundred and six coal samples were taken from main coal mines of twenty-six provinces,autonomous regions,and municipalities in China,according to the resource distribution and coal-forming periods as well as the ...Three hundred and six coal samples were taken from main coal mines of twenty-six provinces,autonomous regions,and municipalities in China,according to the resource distribution and coal-forming periods as well as the coal ranks and coal yields.Nitrogen was determined by using the Kjeldahl method at U.S.Geological Survey(USGS),which exhibit a normal frequency distribution.The nitrogen contents of over 90% Chinese coal vary from 0.52% to 1.41% and the average nitrogen content is recommended to be 0.98%.Nitrogen in coal exists primarily in organic form.There is a slight positive relationship between nitrogen content and coal ranking.展开更多
Non-linear finite element models accounting for large displacements have been used to investigate the behavior of steel built-up shear links that had previously been tested using large-scale experiments. The links wer...Non-linear finite element models accounting for large displacements have been used to investigate the behavior of steel built-up shear links that had previously been tested using large-scale experiments. The links were designed using steel grades with yield points ranging from high to low strengths. The objectives of the numerical analyses were to further investigate the non-linear behavior and to correlate the numerical results with experimental observations. Elasto-plastic as well as cyclic stress-strain material properties were incorporated to study the influence of material behavior on the overall shear link response. Non-linear monotonie analyses of the shear links incorporating the cyclic stress-strain steel properties resulted in similar trends in the response as the backbone curves recorded from the physical experiments. The numerical models of built-up shear links utilizing structural grade steels closely correlated to the experimentally recorded shear strength. Models utilizing low yield point steels overestimated the shear strength, which was caused by the characteristics of cyclic behavior of those steels. The detailed numerical models also allowed for investigation of the plastic strain demands on the different components of the link. It was shown that finite element models combined with appropriate stress-strain relationship may be used with confidence to check the design of shear links of different steel grades and sectional geometries.展开更多
Background: Carbon sequestration through recommended forest management practices is an ecosystem service that helps mitigate climate change and its impacts while generating carbon credits for forestland owners to sell...Background: Carbon sequestration through recommended forest management practices is an ecosystem service that helps mitigate climate change and its impacts while generating carbon credits for forestland owners to sell in cap-and-trade programs. The California’s cap-and-trade program (California’s carbon market hereafter) allows forestland owners from any part of the contiguous United States to supply carbon credits to compliance entities. In this study, we estimate South Carolina (SC) private forestland owners’willingness to accept compensations to participate in the California’s carbon market using a contingent valuation method. Results: We estimate forestland owners’mean willingness to accept as$67 per acre per year. Our results reveal higher probability of participation of forestland owners with interests in preserving forest ecosystems than those who do not. Additionally, forestland owners who trust in information about climate change from scientists or government are willing to participate more than those who do not. Conclusions: Various factors hinder landowners’ability to participate in carbon markets. Forestland owners in SC consider legislative uncertainty and long-time commitment as the main barriers to participation in California’s carbon market. From this research, average forestland tenure in SC is 27 years, which is far less than the 100-year time commitment of the California’s carbon market. Of those who agreed to participate, choosing between adopting and not adopting any of the three main forest management practices in the California’s carbon market:28% are likely to adopt improved forest management (IFM) practices, 24% are likely to adopt reforestation due to understocked forestlands, and 14% are likely to adopt avoided conversion. In another development, the concept of aggregation has dominated discussions in the California’s carbon market of late. It is an advocacy to include small-scale forestlands in the California’s carbon market. To aggregate, different forestland owners will combine their forestlands to participate. We find that 79% of SC forestland owners are willing to aggregate to participate. However, this research is unable to determine how much total forestland is available in SC for carbon market. We recommend future research in the State on forestland owners’participation in carbon market should consider evaluating forestland availability.展开更多
Aims Changes in light and temperature are among the most common and most profound environmental perturbations. The independent effects of light and temperature on photosynthesis and respiration are well studied in sin...Aims Changes in light and temperature are among the most common and most profound environmental perturbations. The independent effects of light and temperature on photosynthesis and respiration are well studied in single leaves, but are less well studied in whole plants. The short and long term influence of light and temperature on carbon use efficiency is also poorly understood, and is commonly modeled to remain constant over a wide range of conditions. We sought to determine the primary effects of changing light at two growth temperatures on photosynthesis, respiration, and their balance, as defined by carbon use efficiency. Methods We separated respiration into growth and maintenance components using whole-canopy gas-exchange in an elevated CO2 environment in a controlled environment, and supplemented that information with tissue analysis. Important findings Decreases in light level decreased carbon use efficiency through a reduction in the maintenance coefficient, increased the growth coefficient, and reduced partitioning of N in protein. Growth temperature did not significantly affect either maintenance or growth respiration coefficients, suggesting that long-term temperature responses can differ greatly from short-term observations.展开更多
Background: Segawa syndrome due to GTP cyclohydrolase deficiency is an autosomal dominant disorder with variable expression, that is clinically characterised by L-dopa responsive, diurnally fluctuating dystonia and pa...Background: Segawa syndrome due to GTP cyclohydrolase deficiency is an autosomal dominant disorder with variable expression, that is clinically characterised by L-dopa responsive, diurnally fluctuating dystonia and parkinsonian symptoms. Objective: To delineate the neurological and psychiatric phenotype in all affected individuals of three extended families. Methods: GTP cyclohydrolase deficiency was documented by biochemical analyses, enzymatic measurements in fibroblasts, and molecular investigations. All affected individuals were examined neurologically, and psychiatric data were systematically reviewed. Results: Eighteen affected patients from three families with proven GTP cyclohydrolase deficiency were identified. Eight patients presenting at less than 20 years of age had typical motor symptoms of dystonia with diurnal variation. Five family members had late-presenting mild dopa-responsive symptoms of rigidity, frequent falls, and tendonitis. Among mutation carriers older than 20 years of age, major depressive disorder, often recurrent, and obsessive-compulsive disorder were strikingly more frequent than observed in the general population. Patients responded well to medication increasing serotonergic neurotransmission and to L-dopa substitution. Sleep disorders including difficulty in sleep onset and maintenance, excessive sleepiness, and frequent disturbing nightmares were present in 55% of patients. Conclusion: Physicians should be aware of this expanded phenotype in affected members of families with GTP cyclohydrolase deficiency.展开更多
Background: Lipedematous alopecia is a rare entity of uncertain origin characterized by a boggy scalp and varying alopecia. Of 11 cases in the literature, 7 occurred in African American women. Classic histopathologic ...Background: Lipedematous alopecia is a rare entity of uncertain origin characterized by a boggy scalp and varying alopecia. Of 11 cases in the literature, 7 occurred in African American women. Classic histopathologic findings include increased subcutaneous tissue, varying inflammation, and an absence of mucin. Some have sought to distinguish this disorder from lipedematous scalp, a condition with similar tactile features, but without alopecia. Observation: We describe a case of lipedematous alopecia in an African American woman who also had findings of discoid lupus erythematosus. Such an observation has not been made previously, and may provide insight into the cause of lipedematous alopecia. This case is contrasted with a case of lipedematous scalp. Conclusion: Some cases of lipedematous alopecia may represent an unusual consequence of discoid lupus erythematosus. Alternatively, it is possible that lipedematous scalp is a benign condition observed in some patients, and that a second insult results in alopecia. Finally, lipedematous alopeciamight share some histopathologic and/or clinical findings with discoid lupus erythematosus, or it may represent a nonspecific reaction pattern to chronic injury.展开更多
Natural scientists have long recognized that regions with similar climate tend to have similar vegetation.Preliminary observations suggest that shrub steppe communities of the western US and western China may be two s...Natural scientists have long recognized that regions with similar climate tend to have similar vegetation.Preliminary observations suggest that shrub steppe communities of the western US and western China may be two such regions with similar annual precipitation,temperature,land use,and vegetation.These cold dry shrub steppes have traditionally been grazed.Despite these similarities,patterns of species dominance are different.Annual species that are rare in China become dominant when introduced to the United States.The objective of this study was to investigate how climate,land use and community structure may explain these patterns of species dominance.Community structure and grazing intensity were measured at 5 sites in each region.This information was combined with a broader review of the literature describing the history of grazing in both basins.Climate was analyzed based on a spatially-gridded,interpolated weather time series (monthly records) and climatological summary (1961-1990 mean conditions) data set from the Climate Research Unit.We found that differences in summer precipitation and winter minimum temperature,land use intensity,and shrub size may all contribute to the dominance of annual species in the Great Basin,particularly Bromus tectorum.In particular,previous work indicates that summer precipitation and winter temperature drive the distribution of Bromus tectorum in the Great Basin.As a result,sites with wet summers and cold springs,similar to the Chinese sites,would not be expected to be dominated by Bromus tectorum.A history of more intense grazing of the Chinese sites,as described in the literature,also is likely to decrease fire frequency,and decreases litter and shrub dominance,all of which have been demonstrated to be important in Bromus tectorum establishment and ultimate dominance.Further research is necessary to determine if other annuals that follow the same pattern of scarcity in the Junggar Basin and dominance in the Great Basin are responding to the same influences.展开更多
Trends in the growing season MODerate resolution Imaging Spectroradiometer (MODIS) Enhanced Vegetation Index (EVI) time-series were analyzed for the period from 2000 to 2010 to understand landscape-level patterns of v...Trends in the growing season MODerate resolution Imaging Spectroradiometer (MODIS) Enhanced Vegetation Index (EVI) time-series were analyzed for the period from 2000 to 2010 to understand landscape-level patterns of vegetation change in ecosystems of arctic Alaska. We compared datasets for vegetation cover types, wetland cover classes, wildfire boundaries since the 1940s, permafrost type, and elevation to identify the most likely combination of factors driving regional changes in habitat quality and ecosystem productivity. Approximately 57% of all arctic ecosystem areas in Alaska were detected with significant (p < 0.05) positive or negative MODIS growing season EVI trends from 2000 to 2010. Nearly all (99%) of these ecosystem areas (covering 178,050 km2) were detected with significant positive growing season EVI trends. The vast majority of the arctic Alaska region detected with significant positive growing season EVI trends was classified as upland tundra cover, although non-forested wetlands (marshes, bogs, fens, and floodplains) were co-located on 8% of that area. Herbaceous wetlands were co-located on 55% of the total area detected with significant negative growing season EVI trends, mostly on the arctic coastal plain and foothills. This evidence supports the hypothesis that temperature (warming) has markedly enhanced the rates of upland tundra vegetation growth across most of arctic Alaska over recent years.展开更多
TiO2 films have been widely applied in photo- voltaic conversion techniques. TiO2 nanotube arrays (TiO2 NAs) can be grown directly on the surface of metal Ti by the anodic oxidation method. Bi2S3 and PbS nanoparticl...TiO2 films have been widely applied in photo- voltaic conversion techniques. TiO2 nanotube arrays (TiO2 NAs) can be grown directly on the surface of metal Ti by the anodic oxidation method. Bi2S3 and PbS nanoparticles (NPs) were firstly co-sensitized on TiOa NAs (denoted as PbS/Bi2S3(n)/TiO2 NAs) by a two-step process containing hydrothermal and sonication-assisted SILAR method. When the concentration of Bi3+ is 5 mmol/L, the best photoelectrical performance was obtained under simulated solar irradiation. The short-circuit photocurrent (Jsc) and photoconversion efficiency (η) of PbS/Bi2S3(5)/TiO2 NAs electrode were 4.70 mA/cm and 1.13 %, respectively.展开更多
Objective: Determine whether waist- to- height ratio (WHtR) or sex- and ag e- specific percentiles of body mass index (BMI)- better identifies cardiovasc ular risk. Study design: The third National Health and Nutritio...Objective: Determine whether waist- to- height ratio (WHtR) or sex- and ag e- specific percentiles of body mass index (BMI)- better identifies cardiovasc ular risk. Study design: The third National Health and Nutrition Examination Sur vey (NHANES III) provided measurements on 7657 participants statistically weight ed to represent 50.05 million youth 4 to 17 years of age. We estimated the subpo pulations corresponding to BMI strata that were normal ( < 85th percentile), at risk for overweight (85th to < 95th percentile), and overweight (≥ 95th percent ile). We chose WHtR cutoff points (0.490 and 0.539) so that subpopulation sizes in the three WHtR strata would equal those in the three BMI strata. For 13 cardi ovascular risk factors we compared mean levels among youth discordant for their BMI and WHtR strata. Results: 726 participants (representing 3.69 million youth) were identified as having WHtR stratum > BMI stratum. Compared with the 603 par ticipants (representing 3.70 million youth) who were discordant in the opposite direction, weighted analyses showed they had higher mean levels of heart rate, l ow- density lipoprotein (LDL) cholesterol, fasting triglycerides, and total cho lesterol (P < .015, adjusted for sex, age, and race- ethnicity). Their mean sys tolic blood pressure was lower, but this difference was eliminated after adjustm ent for their shorter stature. Conclusion: WHtR, a simpler anthropometric index than sex- and age- specific BMI percentiles, better identi- fies youth with a dverse cardiovascular risk factors.展开更多
Objective: To determine the prevalence of ibuprofen-sensitive asthma in schoo l-aged children with mild ormoderate persistent asthma. Study design: A randomi zed, double-blind, placebocontrolled, crossover bronchoprov...Objective: To determine the prevalence of ibuprofen-sensitive asthma in schoo l-aged children with mild ormoderate persistent asthma. Study design: A randomi zed, double-blind, placebocontrolled, crossover bronchoprovocation challenge st udy in children 6 to 18 years of age with mild or moderate persistent asthma. Pa tients received a single dose of ibuprofen or placebo, per randomization, and th en returned 2 to 7 days later to repeat the procedures after taking that study d rug not received at the first visit. At each visit, patients performed spirometr y before and 1/2, 1, 2, and 4 hours after administration of study drug. We defin ed bronchospasm as a ≥20%decrease from baseline in the forced expired volume i n the first second (FEV1) and ibuprofen sensitivity as bronchospasm following ad ministration of ibuprofen but not placebo. Results: Of the 127 patients screened , 100 (mean age, 11 years) completed the study. Two patients met criteria for ib uprofen-sensitive asthma, resulting in a prevalence of 2%(95%CI: 0.2%-7%). Neither patient was known to have had any exposure to ibuprofen before the stud y. Conclusion: The prevalence of ibuprofen-sensitive asthma was low but non-ze ro in this group of children with mild or moderate asthma. The possibility of ib uprofen-induced bronchospasm should be considered before administering ibuprofen to children with asthma.展开更多
Objective: To compare the efficacy and safety of SC depot medroxyprogesterone acetate (DMPA- SC 104) with that of leuprolide acetate in treatment of endometriosis. Design: Phase 3, multicenter, randomized, evaluator- ...Objective: To compare the efficacy and safety of SC depot medroxyprogesterone acetate (DMPA- SC 104) with that of leuprolide acetate in treatment of endometriosis. Design: Phase 3, multicenter, randomized, evaluator- blinded, comparator- controlled trial. Setting: Clinical trial sites in Canada and United States. Patient(s): Two hundred seventy- four women with surgically diagnosed endometriosis. Intervention(s): Intramuscular injections of DMPA- SC (104 mg) or leuprolide acetate (11.25 mg), given every 3 months for 6 months, with 12 months of posttreatment follow- up. Main Outcome Measure(s): Reduction in five endometriosis symptoms or signs (dysmenorrhea, dyspareunia, pelvic pain, pelvic tenderness, pelvic induration); change in bone mineral density (BMD), hypoestrogenic symptoms, bleeding, and weight. Result(s): The depot medroxyprogesterone acetate given SC was statistically equivalent to leuprolide in reducing four of five endometriosis symptoms or signs at the end of treatment (month 6) and in reducing all five symptoms after 12 months’ follow- up (month 18). Patients in the DMPA- SC 104 group showed significantly less BMD loss than did leuprolide patients at month 6, with scores returning to baseline at 12 months’ follow- up. No statistically significant differences in median weight changes were observed between groups. Compared with leuprolide, DMPASC 104 was associated with fewer hypoestrogenic symptoms but more irregular bleeding. Conclusion(s): Efficacy of DMPASC 104 was equivalent to that of leuprolide for reducing endometriosis- associated pain, with less impact on BMD and fewer hypoestrogenic side effects but more bleeding.展开更多
基金the Federal Highway Administration under contract number DTFH61-92-C-00112.
文摘The Federal Highway Administration (FHWA) sponsored a large,multi-year project conducted by the Multidisciplinary Center for Earthquake Engineering Research (MCEER) titled'Seismic Vulnerability of New Highway Construction'(MCEER Project 112),which was completed in 1998.MCEER coordinated the work of many researchers,who performed studies on the seismic design and vulnerability analysis of highway bridges,tunnels,and retaining structures. Extensive research was conducted to provide revisions and improvements to current design and detailing approaches and national design specifications for highway bridges.The program included both analytical and experimental studies,and addressed seismic hazard exposure and ground motion input for the U.S.highway system;foundation design and soil behavior: structural importance,analysis,and response:structural design issues and details;and structural design criteria.
基金supported by United States Department of Agriculture-Agricultural Research Service Current Research Information System Project 5306-21000021-00DMars, Inc. Cooperative Research and Development Agreement (No. 58-3K95-2-1563)
文摘Epicuticular wax forms the outermost protective barrier of the aerial surfaces of land plants, working in concert with other components of the plant cuticle to prevent uncontrolled loss of water and to provide protection against an array of external environmental stress. In this study, chemically- mutagenized populations of rice (Oryza sativa L.) derived from approximately 4 750 M2 families were screened for adhesion of water droplets resulting in a wet leaf/glossy (wig) phenotype. Mutants were identified in 11 independently-derived M2 families. Scanning electron microscopy analysis confirmed the association of the wig phenotype with changes in the epicuticular wax crystals of these plants. The phenotypes of five mutants (7-17A, 26.1, 524.2, 680.2, and 843.1) were confirmed to be the result of single recessive gene mutation. Evaluation of mutants from 3 (6-1A, 7-17A, and 11-39A) of 11 M2 families revealed significant reductions (〉 50%) in surface wax content and increases in cuticle membrane permeability.
基金supported by the National Natural Science Foundation of China (Grant No. 40133010)
文摘Three hundred and six coal samples were taken from main coal mines of twenty-six provinces,autonomous regions,and municipalities in China,according to the resource distribution and coal-forming periods as well as the coal ranks and coal yields.Nitrogen was determined by using the Kjeldahl method at U.S.Geological Survey(USGS),which exhibit a normal frequency distribution.The nitrogen contents of over 90% Chinese coal vary from 0.52% to 1.41% and the average nitrogen content is recommended to be 0.98%.Nitrogen in coal exists primarily in organic form.There is a slight positive relationship between nitrogen content and coal ranking.
基金the Federal Highway Administration through the Highway Project at the Multidisciplinary Center for Earthquake Engineering Researchthe toll bridge retrofit program of the California Department of Transportation through the University of California,San Diego
文摘Non-linear finite element models accounting for large displacements have been used to investigate the behavior of steel built-up shear links that had previously been tested using large-scale experiments. The links were designed using steel grades with yield points ranging from high to low strengths. The objectives of the numerical analyses were to further investigate the non-linear behavior and to correlate the numerical results with experimental observations. Elasto-plastic as well as cyclic stress-strain material properties were incorporated to study the influence of material behavior on the overall shear link response. Non-linear monotonie analyses of the shear links incorporating the cyclic stress-strain steel properties resulted in similar trends in the response as the backbone curves recorded from the physical experiments. The numerical models of built-up shear links utilizing structural grade steels closely correlated to the experimentally recorded shear strength. Models utilizing low yield point steels overestimated the shear strength, which was caused by the characteristics of cyclic behavior of those steels. The detailed numerical models also allowed for investigation of the plastic strain demands on the different components of the link. It was shown that finite element models combined with appropriate stress-strain relationship may be used with confidence to check the design of shear links of different steel grades and sectional geometries.
基金funded by the South Carolina Natural Resources Conservation Service(SC NRCS)with grant number 2021917
文摘Background: Carbon sequestration through recommended forest management practices is an ecosystem service that helps mitigate climate change and its impacts while generating carbon credits for forestland owners to sell in cap-and-trade programs. The California’s cap-and-trade program (California’s carbon market hereafter) allows forestland owners from any part of the contiguous United States to supply carbon credits to compliance entities. In this study, we estimate South Carolina (SC) private forestland owners’willingness to accept compensations to participate in the California’s carbon market using a contingent valuation method. Results: We estimate forestland owners’mean willingness to accept as$67 per acre per year. Our results reveal higher probability of participation of forestland owners with interests in preserving forest ecosystems than those who do not. Additionally, forestland owners who trust in information about climate change from scientists or government are willing to participate more than those who do not. Conclusions: Various factors hinder landowners’ability to participate in carbon markets. Forestland owners in SC consider legislative uncertainty and long-time commitment as the main barriers to participation in California’s carbon market. From this research, average forestland tenure in SC is 27 years, which is far less than the 100-year time commitment of the California’s carbon market. Of those who agreed to participate, choosing between adopting and not adopting any of the three main forest management practices in the California’s carbon market:28% are likely to adopt improved forest management (IFM) practices, 24% are likely to adopt reforestation due to understocked forestlands, and 14% are likely to adopt avoided conversion. In another development, the concept of aggregation has dominated discussions in the California’s carbon market of late. It is an advocacy to include small-scale forestlands in the California’s carbon market. To aggregate, different forestland owners will combine their forestlands to participate. We find that 79% of SC forestland owners are willing to aggregate to participate. However, this research is unable to determine how much total forestland is available in SC for carbon market. We recommend future research in the State on forestland owners’participation in carbon market should consider evaluating forestland availability.
基金Supported by the National Aeronautics and Space Administration Advanced Life Support Programand the National Aeronautics and Space Administration Graduate Student Research Program
文摘Aims Changes in light and temperature are among the most common and most profound environmental perturbations. The independent effects of light and temperature on photosynthesis and respiration are well studied in single leaves, but are less well studied in whole plants. The short and long term influence of light and temperature on carbon use efficiency is also poorly understood, and is commonly modeled to remain constant over a wide range of conditions. We sought to determine the primary effects of changing light at two growth temperatures on photosynthesis, respiration, and their balance, as defined by carbon use efficiency. Methods We separated respiration into growth and maintenance components using whole-canopy gas-exchange in an elevated CO2 environment in a controlled environment, and supplemented that information with tissue analysis. Important findings Decreases in light level decreased carbon use efficiency through a reduction in the maintenance coefficient, increased the growth coefficient, and reduced partitioning of N in protein. Growth temperature did not significantly affect either maintenance or growth respiration coefficients, suggesting that long-term temperature responses can differ greatly from short-term observations.
文摘Background: Segawa syndrome due to GTP cyclohydrolase deficiency is an autosomal dominant disorder with variable expression, that is clinically characterised by L-dopa responsive, diurnally fluctuating dystonia and parkinsonian symptoms. Objective: To delineate the neurological and psychiatric phenotype in all affected individuals of three extended families. Methods: GTP cyclohydrolase deficiency was documented by biochemical analyses, enzymatic measurements in fibroblasts, and molecular investigations. All affected individuals were examined neurologically, and psychiatric data were systematically reviewed. Results: Eighteen affected patients from three families with proven GTP cyclohydrolase deficiency were identified. Eight patients presenting at less than 20 years of age had typical motor symptoms of dystonia with diurnal variation. Five family members had late-presenting mild dopa-responsive symptoms of rigidity, frequent falls, and tendonitis. Among mutation carriers older than 20 years of age, major depressive disorder, often recurrent, and obsessive-compulsive disorder were strikingly more frequent than observed in the general population. Patients responded well to medication increasing serotonergic neurotransmission and to L-dopa substitution. Sleep disorders including difficulty in sleep onset and maintenance, excessive sleepiness, and frequent disturbing nightmares were present in 55% of patients. Conclusion: Physicians should be aware of this expanded phenotype in affected members of families with GTP cyclohydrolase deficiency.
文摘Background: Lipedematous alopecia is a rare entity of uncertain origin characterized by a boggy scalp and varying alopecia. Of 11 cases in the literature, 7 occurred in African American women. Classic histopathologic findings include increased subcutaneous tissue, varying inflammation, and an absence of mucin. Some have sought to distinguish this disorder from lipedematous scalp, a condition with similar tactile features, but without alopecia. Observation: We describe a case of lipedematous alopecia in an African American woman who also had findings of discoid lupus erythematosus. Such an observation has not been made previously, and may provide insight into the cause of lipedematous alopecia. This case is contrasted with a case of lipedematous scalp. Conclusion: Some cases of lipedematous alopecia may represent an unusual consequence of discoid lupus erythematosus. Alternatively, it is possible that lipedematous scalp is a benign condition observed in some patients, and that a second insult results in alopecia. Finally, lipedematous alopeciamight share some histopathologic and/or clinical findings with discoid lupus erythematosus, or it may represent a nonspecific reaction pattern to chronic injury.
基金funded by the US National Science Foundation(1047575)with additional support from the Nevada Agricultural Experiment Station and National Science Foundation Cooperative Agreement(EPS-0814372)
文摘Natural scientists have long recognized that regions with similar climate tend to have similar vegetation.Preliminary observations suggest that shrub steppe communities of the western US and western China may be two such regions with similar annual precipitation,temperature,land use,and vegetation.These cold dry shrub steppes have traditionally been grazed.Despite these similarities,patterns of species dominance are different.Annual species that are rare in China become dominant when introduced to the United States.The objective of this study was to investigate how climate,land use and community structure may explain these patterns of species dominance.Community structure and grazing intensity were measured at 5 sites in each region.This information was combined with a broader review of the literature describing the history of grazing in both basins.Climate was analyzed based on a spatially-gridded,interpolated weather time series (monthly records) and climatological summary (1961-1990 mean conditions) data set from the Climate Research Unit.We found that differences in summer precipitation and winter minimum temperature,land use intensity,and shrub size may all contribute to the dominance of annual species in the Great Basin,particularly Bromus tectorum.In particular,previous work indicates that summer precipitation and winter temperature drive the distribution of Bromus tectorum in the Great Basin.As a result,sites with wet summers and cold springs,similar to the Chinese sites,would not be expected to be dominated by Bromus tectorum.A history of more intense grazing of the Chinese sites,as described in the literature,also is likely to decrease fire frequency,and decreases litter and shrub dominance,all of which have been demonstrated to be important in Bromus tectorum establishment and ultimate dominance.Further research is necessary to determine if other annuals that follow the same pattern of scarcity in the Junggar Basin and dominance in the Great Basin are responding to the same influences.
文摘Trends in the growing season MODerate resolution Imaging Spectroradiometer (MODIS) Enhanced Vegetation Index (EVI) time-series were analyzed for the period from 2000 to 2010 to understand landscape-level patterns of vegetation change in ecosystems of arctic Alaska. We compared datasets for vegetation cover types, wetland cover classes, wildfire boundaries since the 1940s, permafrost type, and elevation to identify the most likely combination of factors driving regional changes in habitat quality and ecosystem productivity. Approximately 57% of all arctic ecosystem areas in Alaska were detected with significant (p < 0.05) positive or negative MODIS growing season EVI trends from 2000 to 2010. Nearly all (99%) of these ecosystem areas (covering 178,050 km2) were detected with significant positive growing season EVI trends. The vast majority of the arctic Alaska region detected with significant positive growing season EVI trends was classified as upland tundra cover, although non-forested wetlands (marshes, bogs, fens, and floodplains) were co-located on 8% of that area. Herbaceous wetlands were co-located on 55% of the total area detected with significant negative growing season EVI trends, mostly on the arctic coastal plain and foothills. This evidence supports the hypothesis that temperature (warming) has markedly enhanced the rates of upland tundra vegetation growth across most of arctic Alaska over recent years.
基金supported by Program of International S&T Cooperation(2013 DFA51050)National Magnetic Confinement Fusion Science Program(2013GB110001)+2 种基金the 863Program(2014AA032701)the National Natural Science Foundation of China(11405138,51302231)the Western Superconducting Technologies Co.,Ltd
文摘TiO2 films have been widely applied in photo- voltaic conversion techniques. TiO2 nanotube arrays (TiO2 NAs) can be grown directly on the surface of metal Ti by the anodic oxidation method. Bi2S3 and PbS nanoparticles (NPs) were firstly co-sensitized on TiOa NAs (denoted as PbS/Bi2S3(n)/TiO2 NAs) by a two-step process containing hydrothermal and sonication-assisted SILAR method. When the concentration of Bi3+ is 5 mmol/L, the best photoelectrical performance was obtained under simulated solar irradiation. The short-circuit photocurrent (Jsc) and photoconversion efficiency (η) of PbS/Bi2S3(5)/TiO2 NAs electrode were 4.70 mA/cm and 1.13 %, respectively.
文摘Objective: Determine whether waist- to- height ratio (WHtR) or sex- and ag e- specific percentiles of body mass index (BMI)- better identifies cardiovasc ular risk. Study design: The third National Health and Nutrition Examination Sur vey (NHANES III) provided measurements on 7657 participants statistically weight ed to represent 50.05 million youth 4 to 17 years of age. We estimated the subpo pulations corresponding to BMI strata that were normal ( < 85th percentile), at risk for overweight (85th to < 95th percentile), and overweight (≥ 95th percent ile). We chose WHtR cutoff points (0.490 and 0.539) so that subpopulation sizes in the three WHtR strata would equal those in the three BMI strata. For 13 cardi ovascular risk factors we compared mean levels among youth discordant for their BMI and WHtR strata. Results: 726 participants (representing 3.69 million youth) were identified as having WHtR stratum > BMI stratum. Compared with the 603 par ticipants (representing 3.70 million youth) who were discordant in the opposite direction, weighted analyses showed they had higher mean levels of heart rate, l ow- density lipoprotein (LDL) cholesterol, fasting triglycerides, and total cho lesterol (P < .015, adjusted for sex, age, and race- ethnicity). Their mean sys tolic blood pressure was lower, but this difference was eliminated after adjustm ent for their shorter stature. Conclusion: WHtR, a simpler anthropometric index than sex- and age- specific BMI percentiles, better identi- fies youth with a dverse cardiovascular risk factors.
文摘Objective: To determine the prevalence of ibuprofen-sensitive asthma in schoo l-aged children with mild ormoderate persistent asthma. Study design: A randomi zed, double-blind, placebocontrolled, crossover bronchoprovocation challenge st udy in children 6 to 18 years of age with mild or moderate persistent asthma. Pa tients received a single dose of ibuprofen or placebo, per randomization, and th en returned 2 to 7 days later to repeat the procedures after taking that study d rug not received at the first visit. At each visit, patients performed spirometr y before and 1/2, 1, 2, and 4 hours after administration of study drug. We defin ed bronchospasm as a ≥20%decrease from baseline in the forced expired volume i n the first second (FEV1) and ibuprofen sensitivity as bronchospasm following ad ministration of ibuprofen but not placebo. Results: Of the 127 patients screened , 100 (mean age, 11 years) completed the study. Two patients met criteria for ib uprofen-sensitive asthma, resulting in a prevalence of 2%(95%CI: 0.2%-7%). Neither patient was known to have had any exposure to ibuprofen before the stud y. Conclusion: The prevalence of ibuprofen-sensitive asthma was low but non-ze ro in this group of children with mild or moderate asthma. The possibility of ib uprofen-induced bronchospasm should be considered before administering ibuprofen to children with asthma.
文摘Objective: To compare the efficacy and safety of SC depot medroxyprogesterone acetate (DMPA- SC 104) with that of leuprolide acetate in treatment of endometriosis. Design: Phase 3, multicenter, randomized, evaluator- blinded, comparator- controlled trial. Setting: Clinical trial sites in Canada and United States. Patient(s): Two hundred seventy- four women with surgically diagnosed endometriosis. Intervention(s): Intramuscular injections of DMPA- SC (104 mg) or leuprolide acetate (11.25 mg), given every 3 months for 6 months, with 12 months of posttreatment follow- up. Main Outcome Measure(s): Reduction in five endometriosis symptoms or signs (dysmenorrhea, dyspareunia, pelvic pain, pelvic tenderness, pelvic induration); change in bone mineral density (BMD), hypoestrogenic symptoms, bleeding, and weight. Result(s): The depot medroxyprogesterone acetate given SC was statistically equivalent to leuprolide in reducing four of five endometriosis symptoms or signs at the end of treatment (month 6) and in reducing all five symptoms after 12 months’ follow- up (month 18). Patients in the DMPA- SC 104 group showed significantly less BMD loss than did leuprolide patients at month 6, with scores returning to baseline at 12 months’ follow- up. No statistically significant differences in median weight changes were observed between groups. Compared with leuprolide, DMPASC 104 was associated with fewer hypoestrogenic symptoms but more irregular bleeding. Conclusion(s): Efficacy of DMPASC 104 was equivalent to that of leuprolide for reducing endometriosis- associated pain, with less impact on BMD and fewer hypoestrogenic side effects but more bleeding.