This review aimed to determine the prevalence of the insecticide resistance status of the field-collected Aedes(Ae.)aegypti and Ae.albopictus in Malaysia from 2010 to 2022 towards carbamates,organochlorines,organophos...This review aimed to determine the prevalence of the insecticide resistance status of the field-collected Aedes(Ae.)aegypti and Ae.albopictus in Malaysia from 2010 to 2022 towards carbamates,organochlorines,organophosphates and pyrethroids.Biological and environmental controls were summarized with an emphasis on the mosquito vector control strategies in Malaysia.The information in this review was extracted from several databases such as PubMed(MEDLINE),Science Direct and Scopus by using keywords including“insecticide resistance”,“carbamate resistance”,“organochlorine resistance”,“organophosphate resistance”,“pyrethroid resistance”,“Aedes”and“Malaysia”,between January 2022 and December 2022.Distribution of resistant Ae.aegypti and Ae.albopictus in Malaysia was mapped using QGIS software.Insecticide resistance in both Ae.aegypti and Ae.albopictus is widespread in Malaysia,although the rates vary by states.The most notable was the steep increase in permethrin resistance of Ae.aegypti in Selangor,Malaysia,over the past decade.Ae.albopictus also displayed moderate resistance to permethrin,though not as widespread as Ae.aegypti in Selangor,but showed sign of resistance in Sarawak,East Malaysia.Resistance towards four main classes of insecticides have been widely documented in Malaysia.The extensive resistance towards permethrin in Malaysia which is one of the current insecticides used in Malaysia suggested that policies supporting the widespread use of permethrin fogging needs further evaluation.展开更多
Objective: To assess the insecticide susceptibility status of Anopheles cracens(An.cracens) and Anopheles maculatus(An.maculatus) from knowlesi malaria endemic areas in Peninsular Malaysia towards DDT, malathion and d...Objective: To assess the insecticide susceptibility status of Anopheles cracens(An.cracens) and Anopheles maculatus(An.maculatus) from knowlesi malaria endemic areas in Peninsular Malaysia towards DDT, malathion and deltamethrin and to determine the resistance mechanism involved.Methods: Adult and larval mosquitos were collected for surveillance.Susceptibility status of Anopheles was determined using the standard WHO adult bioassay, larval bioassay and biochemical enzyme assay.Results: WHO adult bioassay results indicated An.cracens collected from Kampung Sungai Ular, Pahang was resistant towards 4% DDT, while An.maculatus collected from Kampung Sokor, Kelantan and Kampung Sungai Lui, Selangor exhibited resistance towards 4% DDT.However, the enzyme activity profiles varied according to strains and species.The resistance ratio of larval bioassay, showed that all strains and species tested were susceptible to malathion and temephos.Conclusions: Since only a few anopheline strains exhibited low level of insecticide resistance towards malathion, DDT and temephos.These insecticides are still considered effective for vector control program towards An.cracens and An.maculatus.展开更多
Objective:To investigate oxidative stress,hemoglobin percentage and erythrocyte osmotic fragility in various aging groups.Methods:A total of 200 healthy volunteers of hoth genders between age group 20-65 years were se...Objective:To investigate oxidative stress,hemoglobin percentage and erythrocyte osmotic fragility in various aging groups.Methods:A total of 200 healthy volunteers of hoth genders between age group 20-65 years were selected by random method.Determination of hemoglobin percentage was done employing modified cyanide method of Dacie and Lewis.The erythrocyte lysis was observed in hypotonic solution of buffered saline at varying concentrations and optical density was measured at 540 nm.The extent of lipid peroxidation in form of malondialdehyde was measured by thiobarbituric acid method.Results:The study found a significant decrease in hemoglobin percentage,increase in erythrocyte osmotic fragility and increased lipid peroxidation in form of malondialdehyde with increasing age.Conclusions:Supplementation of antioxidants may prevent the oxidative injury in elderly group of subjects.展开更多
With the rapid development of the Internet,the amount of data recorded on the Internet has increased dramatically.It is becoming more and more urgent to effectively obtain the specific information we need from the vas...With the rapid development of the Internet,the amount of data recorded on the Internet has increased dramatically.It is becoming more and more urgent to effectively obtain the specific information we need from the vast ocean of data.In this study,we propose a novel collaborative filtering algorithm for generating recommendations in e-commerce.This study has two main innovations.First,we propose a mechanismthat embeds temporal behavior information to find a neighbor set in which each neighbor has a very significant impact on the current user or item.Second,we propose a novel collaborative filtering algorithm by injecting the neighbor set into probability matrix factorization.We compared the proposed method with several state-of-the-art alternatives on real datasets.The experimental results show that our proposed method outperforms the prevailing approaches.展开更多
Objective:To investigate the antioxidant,antibacterial,and chemical ingredients of Ardisia elliptica(A.elliptica) methanolic extracts.Methods:The plant was extracted using methanol.Antibacterial and antioxidant activi...Objective:To investigate the antioxidant,antibacterial,and chemical ingredients of Ardisia elliptica(A.elliptica) methanolic extracts.Methods:The plant was extracted using methanol.Antibacterial and antioxidant activities were evaluated.Results:The results showed that both fruit and leaf extract of A.elliptica have significant antibacterial activities against Gram-positive and Gram-negative bacteria.Fruit extracts showed higher content of phenolic(71 ± 0.03 GAE/mg extract dry weight),in comparison to the leaf extracts(37 ± 0.05 GAE/mg extract dry weight).Flavonoid content,and Fe2+chelating activity of fruit extracts were higher than leaf extract.The percentage radical inhibition of fruit extract is found to be higher(70%) than that of leaf extract(60%).LCMS results indicated that the major compounds in the fruit extract were Gingerol,Aspidin,Kampherol,and Stercuresin,while the leaf extract contained Gingerol,Aspidin,Triangularin,and Salicyl acyl glucuronide.Furthermore,the results of GCMS indicated that fruit extract contained these major compounds:Vitamin E Tocopherol,5-hepylresornicol,2-Nonylmalonic acid,5-pentadecylresornicol,and Stigmasta-7-22-dien-3-ol.However,leaf extract of A.elliptica contained these major compounds:Alpha Amyrenol,4,4,6,6a,6b,8,8a,9,10,11,12,12 a,14,14 a,14 b octadehydro-2H-picen-3-one,and Lonasterol,4-t-Butyl-2-[4-nitrophenyl] phenol.Conclusions:The results provide evidence that fruit and leaf of A.elliptica extracts might indeed be used as a potential source of effective natural antimicrobial and antioxidant agents in pharmaceutical and food industries.展开更多
Objective:To study the usefulness of traditional lipid profile levels in screening subjects who had developed chest pain due lo cardiac event as indicated by a positive troponin I test.Methods:In this retrospective st...Objective:To study the usefulness of traditional lipid profile levels in screening subjects who had developed chest pain due lo cardiac event as indicated by a positive troponin I test.Methods:In this retrospective study data of ihe 430 patients presented lo the emergency department with symptoms of cardiac ischemia who underwent both troponin and lipid profiles tests were compared with the lipid profiles of 165 normal healthy subjects(controls).The troponin was detected qualitatively when a specimen contains troponin I(cTnI)above the 99th percentile(TnI>0.5 ng/mL).The total cholesterol,high density lipoproteins cholesterol,very low density lipoproteins and Iriacvl glycerol levels were also analyzed and Ion densilv lipoprotein level was calculated using Friedewald's formula.Results:Patients with chest pain and positive troponin test(with confirmed cardiac event)were found lo have significantly elevated levels of total cholesterol,triacyl glycerol levels,low density lipoprotein level and significantly reduced high densilv lipoproteins cholesterol levels when compared lo the patients who experienced only chesl pain(negative troponin)and healthy controls.Conclusions:Traditional lipid profile levels is still can be used in screening popiilalions lo identify the subjecis with high risk of developing cardiacevent in case if the laboratory set up has not troponin test facilities.展开更多
The world demands for halal products,covering foods,cosmetics,pharmaceuticals,services and other products,will continue to grow with the increase in global population,especially the Muslims.It is forecasted that in 20...The world demands for halal products,covering foods,cosmetics,pharmaceuticals,services and other products,will continue to grow with the increase in global population,especially the Muslims.It is forecasted that in 2030,Muslim population will cover 27%of the global population.The halal industry is a new growth sector in the Malaysian manufacturing sector and is the fastest growing global business across the world.Increase in value of global halal commodity,with a huge market of USD 2.3 trillion(excluding banking)and is expected to grow each year.展开更多
目的:评价一种中药植物鞭檐犁头尖(T.flagelliforme)作为抗癌药物的临床前研究的系统综述。方法:对Scopus、PubMed、Web of Science、ScienceDirect、LILACS、EBSCO Medline、Mendeley等7个数据库进行全面检索,检索时间截止到2023年9月...目的:评价一种中药植物鞭檐犁头尖(T.flagelliforme)作为抗癌药物的临床前研究的系统综述。方法:对Scopus、PubMed、Web of Science、ScienceDirect、LILACS、EBSCO Medline、Mendeley等7个数据库进行全面检索,检索时间截止到2023年9月8日。排除了临床试验和非原创的同行评议报告后,鞭檐犁头尖的提取物,组成,或分离化合物的体内外研究且经过同行评审的英文文献均被纳入。本研究定性评估了鞭檐犁头尖对不同肿瘤细胞、肿瘤大小和作用机制的有效性。证据质量由三名独立评估人员使用ToxRTool进行评估,并验证其一致性。结果:检索后共纳入27项研究:22项体外研究,4项体内研究,1项体内外研究。结果发现鞭檐犁头尖对白血病、乳腺癌、结直肠癌和肺癌有效。大多数研究的评估为“有限制的可靠”。鞭檐犁头尖通过阻断细胞周期、活化caspase-3/-9、分解PARP、裂解DNA、减少生存素含量、降低ROS表达、抑制COX-2和HSP70表达和抑制NF-kB通路等来诱导细胞凋亡。当与干扰素联合使用时,其能阻碍血管生成。结论:尽管鞭檐犁头尖具有良好的抗癌活性,但其作为单独抗癌药物的疗效尚不确定。它似乎更适合用于癌症的补充或联合治疗。研究设计不理想,报告不完整,以及在多篇文章中没有纳入适当的阳性对照和统计分析可能是本研究缺乏结论性证据的原因。展开更多
Teacher self-efficacy is an important predictor in teacher’s professional career for inquiry-based instruction.This study investigated the factors(gender,educational level,and teaching experience)associated with scie...Teacher self-efficacy is an important predictor in teacher’s professional career for inquiry-based instruction.This study investigated the factors(gender,educational level,and teaching experience)associated with science teachers’self-efficacy in instructional strategies,classroom management,and student engagement in teaching scientific inquiry.A questionnaire was used for data collection from 47 practicing teachers in state schools in 2018.A General Linear Model(GLM)Univariate analysis using SPSS 21.00 programme was used for data analysis.Fact findings revealed that mean perceived self-efficacy in inquiry-based instruction was considerably high irrespective of gender,education level,and teaching experience.Neither teacher self-efficacy in student engagement nor classroom management did not show statistically significant difference according to gender,education level,and teaching experience.However,results concluded that science teaching experience was a significant predictor of self-efficacy in instructional strategies of inquiry-based instruction.展开更多
Micro-expression is manifested through subtle and brief facial movements that relay the genuine person’s hidden emotion.In a sequence of videos,there is a frame that captures the maximum facial differences,which is c...Micro-expression is manifested through subtle and brief facial movements that relay the genuine person’s hidden emotion.In a sequence of videos,there is a frame that captures the maximum facial differences,which is called the apex frame.Therefore,apex frame spotting is a crucial sub-module in a micro-expression recognition system.However,this spotting task is very challenging due to the characteristics of micro-expression that occurs in a short duration with low-intensity muscle movements.Moreover,most of the existing automated works face difficulties in differentiating micro-expressions from other facial movements.Therefore,this paper presents a deep learning model with an attention mechanism to spot the micro-expression apex frame from optical flow images.The attention mechanism is embedded into the model so that more weights can be allocated to the regions that manifest the facial movements with higher intensity.The method proposed in this paper has been tested and verified on two spontaneous micro-expression databases,namely Spontaneous Micro-facial Movement(SAMM)and Chinese Academy of Sciences Micro-expression(CASME)II databases.The proposed system performance is evaluated by using the Mean Absolute Error(MAE)metric that measures the distance between the predicted apex frame and the ground truth label.The best MAE of 14.90 was obtained when a combination of five convolutional layers,local response normalization,and attention mechanism is used to model the apex frame spotting.Even with limited datasets,the results have proven that the attention mechanism has better emphasized the regions where the facial movements likely to occur and hence,improves the spotting performance.展开更多
Through reviewing and summarizing the existing research on consumer motivation,and combining the characteristics of human behavior and the objective needs of environmental protection,this paper analyzes and defines co...Through reviewing and summarizing the existing research on consumer motivation,and combining the characteristics of human behavior and the objective needs of environmental protection,this paper analyzes and defines consumers’purchase motivation.In the context of environmental protection,purchase motivation is divided into demand motivation,value recognition motivation,recognition motivation,and interest motivation.Their definitions are given in this paper,which provides a conceptual basis for further research on the influence of purchase motivation on consumer behavior in the context of environmental protection.展开更多
胰岛素抵抗(insulin resistance,IR)及其信号调控途径紊乱是很多胰岛素靶器官或组织发生病变并缓慢进展的机制之一。其临床诊断指标是基于空腹血糖和空腹血清胰岛素的"稳态模型评估胰岛素抵抗(the homeostatic model of insulin re...胰岛素抵抗(insulin resistance,IR)及其信号调控途径紊乱是很多胰岛素靶器官或组织发生病变并缓慢进展的机制之一。其临床诊断指标是基于空腹血糖和空腹血清胰岛素的"稳态模型评估胰岛素抵抗(the homeostatic model of insulin resistance,HOMA-IR)"指数,此外,包括脂联素在内的新兴IR生物标记物也可作为诊断的参考指标;其影响因素有肥胖、慢性微炎症、缺乏运动等;其主要信号调控途径包括胰岛素受体底物1(insulin receptor substrate 1,IRS1)/磷脂酰肌醇3激酶(phosphatidylinositol-3-kinase,PI3K)/丝氨酸-苏氨酸激酶(serine-threonine kinase,Akt)通路、丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)通路、Smad3通路等。临床上,可通过促进胰岛素分泌、增强胰岛素信号活性来提高胰岛素敏感性,改善IR。目前,用以治疗IR的胰岛素增敏剂不仅有噻唑烷二酮及其衍生物,还有新近发现的二甲双胍和维生素D。此外,一些单味中药提取物和中药复方,如黄蜀葵花总黄酮、黄连素、黄芪多糖以及黄芪汤等也有改善IR的作用。在慢性肾脏病领域,针对胰岛素靶器官的常见病变——糖尿病早期肾损害,基于足细胞IR信号调控途径的中药干预性研究是今后的重要方向之一。展开更多
基金support from Ministry of Higher Education Malaysia for funding Fundamental Research Grant Scheme FRGS 2020-1 (FRGS/1/2020/WAB02/MSU/02/1)Management and Science University for funding Seed Research Grant Phase 1/2020 (SG-008-012020-FHLS).
文摘This review aimed to determine the prevalence of the insecticide resistance status of the field-collected Aedes(Ae.)aegypti and Ae.albopictus in Malaysia from 2010 to 2022 towards carbamates,organochlorines,organophosphates and pyrethroids.Biological and environmental controls were summarized with an emphasis on the mosquito vector control strategies in Malaysia.The information in this review was extracted from several databases such as PubMed(MEDLINE),Science Direct and Scopus by using keywords including“insecticide resistance”,“carbamate resistance”,“organochlorine resistance”,“organophosphate resistance”,“pyrethroid resistance”,“Aedes”and“Malaysia”,between January 2022 and December 2022.Distribution of resistant Ae.aegypti and Ae.albopictus in Malaysia was mapped using QGIS software.Insecticide resistance in both Ae.aegypti and Ae.albopictus is widespread in Malaysia,although the rates vary by states.The most notable was the steep increase in permethrin resistance of Ae.aegypti in Selangor,Malaysia,over the past decade.Ae.albopictus also displayed moderate resistance to permethrin,though not as widespread as Ae.aegypti in Selangor,but showed sign of resistance in Sarawak,East Malaysia.Resistance towards four main classes of insecticides have been widely documented in Malaysia.The extensive resistance towards permethrin in Malaysia which is one of the current insecticides used in Malaysia suggested that policies supporting the widespread use of permethrin fogging needs further evaluation.
文摘Objective: To assess the insecticide susceptibility status of Anopheles cracens(An.cracens) and Anopheles maculatus(An.maculatus) from knowlesi malaria endemic areas in Peninsular Malaysia towards DDT, malathion and deltamethrin and to determine the resistance mechanism involved.Methods: Adult and larval mosquitos were collected for surveillance.Susceptibility status of Anopheles was determined using the standard WHO adult bioassay, larval bioassay and biochemical enzyme assay.Results: WHO adult bioassay results indicated An.cracens collected from Kampung Sungai Ular, Pahang was resistant towards 4% DDT, while An.maculatus collected from Kampung Sokor, Kelantan and Kampung Sungai Lui, Selangor exhibited resistance towards 4% DDT.However, the enzyme activity profiles varied according to strains and species.The resistance ratio of larval bioassay, showed that all strains and species tested were susceptible to malathion and temephos.Conclusions: Since only a few anopheline strains exhibited low level of insecticide resistance towards malathion, DDT and temephos.These insecticides are still considered effective for vector control program towards An.cracens and An.maculatus.
文摘Objective:To investigate oxidative stress,hemoglobin percentage and erythrocyte osmotic fragility in various aging groups.Methods:A total of 200 healthy volunteers of hoth genders between age group 20-65 years were selected by random method.Determination of hemoglobin percentage was done employing modified cyanide method of Dacie and Lewis.The erythrocyte lysis was observed in hypotonic solution of buffered saline at varying concentrations and optical density was measured at 540 nm.The extent of lipid peroxidation in form of malondialdehyde was measured by thiobarbituric acid method.Results:The study found a significant decrease in hemoglobin percentage,increase in erythrocyte osmotic fragility and increased lipid peroxidation in form of malondialdehyde with increasing age.Conclusions:Supplementation of antioxidants may prevent the oxidative injury in elderly group of subjects.
基金supported by the National Natural Science Foundation of China under Grant Nos.81873915,61702225 and 61806026Ministry of Science and Technology Key Research and Development Program of China under Grant No.2018YFC0116902+3 种基金by the Natural Science Foundation of Jiangsu Province under Grant No.BK20180956by the 2018 Six Talent Peaks Project of Jiangsu Province under Grant No.XYDXX-127by the Science and Technology demonstration project of social development of Wuxi under Grant WX18IVJN002by the Philosophy and Social Science Foundation of Jiangsu Province(18YSC009).
文摘With the rapid development of the Internet,the amount of data recorded on the Internet has increased dramatically.It is becoming more and more urgent to effectively obtain the specific information we need from the vast ocean of data.In this study,we propose a novel collaborative filtering algorithm for generating recommendations in e-commerce.This study has two main innovations.First,we propose a mechanismthat embeds temporal behavior information to find a neighbor set in which each neighbor has a very significant impact on the current user or item.Second,we propose a novel collaborative filtering algorithm by injecting the neighbor set into probability matrix factorization.We compared the proposed method with several state-of-the-art alternatives on real datasets.The experimental results show that our proposed method outperforms the prevailing approaches.
基金University of Malaya for research grants PG085-2012B,RG546-14HTM and RG313-14FR
文摘Objective:To investigate the antioxidant,antibacterial,and chemical ingredients of Ardisia elliptica(A.elliptica) methanolic extracts.Methods:The plant was extracted using methanol.Antibacterial and antioxidant activities were evaluated.Results:The results showed that both fruit and leaf extract of A.elliptica have significant antibacterial activities against Gram-positive and Gram-negative bacteria.Fruit extracts showed higher content of phenolic(71 ± 0.03 GAE/mg extract dry weight),in comparison to the leaf extracts(37 ± 0.05 GAE/mg extract dry weight).Flavonoid content,and Fe2+chelating activity of fruit extracts were higher than leaf extract.The percentage radical inhibition of fruit extract is found to be higher(70%) than that of leaf extract(60%).LCMS results indicated that the major compounds in the fruit extract were Gingerol,Aspidin,Kampherol,and Stercuresin,while the leaf extract contained Gingerol,Aspidin,Triangularin,and Salicyl acyl glucuronide.Furthermore,the results of GCMS indicated that fruit extract contained these major compounds:Vitamin E Tocopherol,5-hepylresornicol,2-Nonylmalonic acid,5-pentadecylresornicol,and Stigmasta-7-22-dien-3-ol.However,leaf extract of A.elliptica contained these major compounds:Alpha Amyrenol,4,4,6,6a,6b,8,8a,9,10,11,12,12 a,14,14 a,14 b octadehydro-2H-picen-3-one,and Lonasterol,4-t-Butyl-2-[4-nitrophenyl] phenol.Conclusions:The results provide evidence that fruit and leaf of A.elliptica extracts might indeed be used as a potential source of effective natural antimicrobial and antioxidant agents in pharmaceutical and food industries.
基金Supported by Confederation of Epidemiological Associations registered under Govt of Kerala.Grant No.30-955/2012 CEA
文摘Objective:To study the usefulness of traditional lipid profile levels in screening subjects who had developed chest pain due lo cardiac event as indicated by a positive troponin I test.Methods:In this retrospective study data of ihe 430 patients presented lo the emergency department with symptoms of cardiac ischemia who underwent both troponin and lipid profiles tests were compared with the lipid profiles of 165 normal healthy subjects(controls).The troponin was detected qualitatively when a specimen contains troponin I(cTnI)above the 99th percentile(TnI>0.5 ng/mL).The total cholesterol,high density lipoproteins cholesterol,very low density lipoproteins and Iriacvl glycerol levels were also analyzed and Ion densilv lipoprotein level was calculated using Friedewald's formula.Results:Patients with chest pain and positive troponin test(with confirmed cardiac event)were found lo have significantly elevated levels of total cholesterol,triacyl glycerol levels,low density lipoprotein level and significantly reduced high densilv lipoproteins cholesterol levels when compared lo the patients who experienced only chesl pain(negative troponin)and healthy controls.Conclusions:Traditional lipid profile levels is still can be used in screening popiilalions lo identify the subjecis with high risk of developing cardiacevent in case if the laboratory set up has not troponin test facilities.
文摘The world demands for halal products,covering foods,cosmetics,pharmaceuticals,services and other products,will continue to grow with the increase in global population,especially the Muslims.It is forecasted that in 2030,Muslim population will cover 27%of the global population.The halal industry is a new growth sector in the Malaysian manufacturing sector and is the fastest growing global business across the world.Increase in value of global halal commodity,with a huge market of USD 2.3 trillion(excluding banking)and is expected to grow each year.
文摘目的:评价一种中药植物鞭檐犁头尖(T.flagelliforme)作为抗癌药物的临床前研究的系统综述。方法:对Scopus、PubMed、Web of Science、ScienceDirect、LILACS、EBSCO Medline、Mendeley等7个数据库进行全面检索,检索时间截止到2023年9月8日。排除了临床试验和非原创的同行评议报告后,鞭檐犁头尖的提取物,组成,或分离化合物的体内外研究且经过同行评审的英文文献均被纳入。本研究定性评估了鞭檐犁头尖对不同肿瘤细胞、肿瘤大小和作用机制的有效性。证据质量由三名独立评估人员使用ToxRTool进行评估,并验证其一致性。结果:检索后共纳入27项研究:22项体外研究,4项体内研究,1项体内外研究。结果发现鞭檐犁头尖对白血病、乳腺癌、结直肠癌和肺癌有效。大多数研究的评估为“有限制的可靠”。鞭檐犁头尖通过阻断细胞周期、活化caspase-3/-9、分解PARP、裂解DNA、减少生存素含量、降低ROS表达、抑制COX-2和HSP70表达和抑制NF-kB通路等来诱导细胞凋亡。当与干扰素联合使用时,其能阻碍血管生成。结论:尽管鞭檐犁头尖具有良好的抗癌活性,但其作为单独抗癌药物的疗效尚不确定。它似乎更适合用于癌症的补充或联合治疗。研究设计不理想,报告不完整,以及在多篇文章中没有纳入适当的阳性对照和统计分析可能是本研究缺乏结论性证据的原因。
基金the Ministry of Higher Education of Malaysia for the Malaysian International Scholarship and research funding under FRGS vote No. R.J13000.7824.4F810
基金the Universiti Teknikal Malaysia Melaka (UTeM)the Ministry of Education, Malaysia for being financial sponsorsUniversiti Kebangsaan Malaysia (UKM) for the financial support under research grants GUP-2012-040 and AP-2012-014
文摘Teacher self-efficacy is an important predictor in teacher’s professional career for inquiry-based instruction.This study investigated the factors(gender,educational level,and teaching experience)associated with science teachers’self-efficacy in instructional strategies,classroom management,and student engagement in teaching scientific inquiry.A questionnaire was used for data collection from 47 practicing teachers in state schools in 2018.A General Linear Model(GLM)Univariate analysis using SPSS 21.00 programme was used for data analysis.Fact findings revealed that mean perceived self-efficacy in inquiry-based instruction was considerably high irrespective of gender,education level,and teaching experience.Neither teacher self-efficacy in student engagement nor classroom management did not show statistically significant difference according to gender,education level,and teaching experience.However,results concluded that science teaching experience was a significant predictor of self-efficacy in instructional strategies of inquiry-based instruction.
基金Authors would like to acknowledge funding from Universiti Kebangsaan Malaysia(Geran Universiti Penyelidikan:GUP-2019-008 and Dana Padanan Kolaborasi:DPK-2021-012).
文摘Micro-expression is manifested through subtle and brief facial movements that relay the genuine person’s hidden emotion.In a sequence of videos,there is a frame that captures the maximum facial differences,which is called the apex frame.Therefore,apex frame spotting is a crucial sub-module in a micro-expression recognition system.However,this spotting task is very challenging due to the characteristics of micro-expression that occurs in a short duration with low-intensity muscle movements.Moreover,most of the existing automated works face difficulties in differentiating micro-expressions from other facial movements.Therefore,this paper presents a deep learning model with an attention mechanism to spot the micro-expression apex frame from optical flow images.The attention mechanism is embedded into the model so that more weights can be allocated to the regions that manifest the facial movements with higher intensity.The method proposed in this paper has been tested and verified on two spontaneous micro-expression databases,namely Spontaneous Micro-facial Movement(SAMM)and Chinese Academy of Sciences Micro-expression(CASME)II databases.The proposed system performance is evaluated by using the Mean Absolute Error(MAE)metric that measures the distance between the predicted apex frame and the ground truth label.The best MAE of 14.90 was obtained when a combination of five convolutional layers,local response normalization,and attention mechanism is used to model the apex frame spotting.Even with limited datasets,the results have proven that the attention mechanism has better emphasized the regions where the facial movements likely to occur and hence,improves the spotting performance.
基金Scientific Research Project of Hefei Technology College(2024SKB08)Anhui Province Key Scientific Research Project(2022AH052219)。
文摘Through reviewing and summarizing the existing research on consumer motivation,and combining the characteristics of human behavior and the objective needs of environmental protection,this paper analyzes and defines consumers’purchase motivation.In the context of environmental protection,purchase motivation is divided into demand motivation,value recognition motivation,recognition motivation,and interest motivation.Their definitions are given in this paper,which provides a conceptual basis for further research on the influence of purchase motivation on consumer behavior in the context of environmental protection.
文摘胰岛素抵抗(insulin resistance,IR)及其信号调控途径紊乱是很多胰岛素靶器官或组织发生病变并缓慢进展的机制之一。其临床诊断指标是基于空腹血糖和空腹血清胰岛素的"稳态模型评估胰岛素抵抗(the homeostatic model of insulin resistance,HOMA-IR)"指数,此外,包括脂联素在内的新兴IR生物标记物也可作为诊断的参考指标;其影响因素有肥胖、慢性微炎症、缺乏运动等;其主要信号调控途径包括胰岛素受体底物1(insulin receptor substrate 1,IRS1)/磷脂酰肌醇3激酶(phosphatidylinositol-3-kinase,PI3K)/丝氨酸-苏氨酸激酶(serine-threonine kinase,Akt)通路、丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)通路、Smad3通路等。临床上,可通过促进胰岛素分泌、增强胰岛素信号活性来提高胰岛素敏感性,改善IR。目前,用以治疗IR的胰岛素增敏剂不仅有噻唑烷二酮及其衍生物,还有新近发现的二甲双胍和维生素D。此外,一些单味中药提取物和中药复方,如黄蜀葵花总黄酮、黄连素、黄芪多糖以及黄芪汤等也有改善IR的作用。在慢性肾脏病领域,针对胰岛素靶器官的常见病变——糖尿病早期肾损害,基于足细胞IR信号调控途径的中药干预性研究是今后的重要方向之一。