AIM To determine the effect of childhood obesity and insulin resistance on bone health. METHODS We conducted a cross sectional study in pubertal adolescents and young adults 13-20 years old who were either overweight/...AIM To determine the effect of childhood obesity and insulin resistance on bone health. METHODS We conducted a cross sectional study in pubertal adolescents and young adults 13-20 years old who were either overweight/obese or normal weight. Participants were Tanner 3 or above for pubertal stage, and had fasting blood work done to measure glucose, insulin, C-reactive protein and lipid levels. Homeostatic model of insulin resistance(HOMA-IR) was calculated using the formula(Fasting Blood Glucose *Insulin/405). Body composition and bone mineral density were measured using dual energy X-ray absorptiometry(DXA; Hologic QDR 4500, Waltham, MA, United Kingdom). RESULTS Percent trunk fat was associated inversely with whole body bone mineral content(BMC), whereas HOMA-IR was associated positively with whole body BMC.CONCLUSION Our results suggest that abdominal adiposity may have an adverse effect on whole body bone parameters and that this effect is not mediated by insulin resistance.展开更多
Since severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)emerged,we have followed this pandemic with great interest and concern from Europe(Navarra-Spain)and the United States(Boston-Massachusetts).We were exp...Since severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)emerged,we have followed this pandemic with great interest and concern from Europe(Navarra-Spain)and the United States(Boston-Massachusetts).We were expecting children to present to emergency departments with the“classical COVID-19 symptoms-triad”such as fever,cough,and a range of respiratory distress[1]and we had learned from countries affected earlier by the virus,that it appeared to be less common and relatively mild in children[2,3].展开更多
The World Health Organization(WHO)announced COVID-19 as a global pandemic in March of 2020[1].The COVID-19 pandemic may persist for a long period of time.Global prevention and control becomes a complex and challenging...The World Health Organization(WHO)announced COVID-19 as a global pandemic in March of 2020[1].The COVID-19 pandemic may persist for a long period of time.Global prevention and control becomes a complex and challenging task,and such efforts should be sustained.Although general measures,such as social distancing,face masks,respiratory hygiene and hand sanitization,will bear fruits for decreasing spread of other respiratory illnesses including influenza,the specific prevention through vaccination is a key focus especially in the upcoming winter and spring seasons[2].展开更多
文摘AIM To determine the effect of childhood obesity and insulin resistance on bone health. METHODS We conducted a cross sectional study in pubertal adolescents and young adults 13-20 years old who were either overweight/obese or normal weight. Participants were Tanner 3 or above for pubertal stage, and had fasting blood work done to measure glucose, insulin, C-reactive protein and lipid levels. Homeostatic model of insulin resistance(HOMA-IR) was calculated using the formula(Fasting Blood Glucose *Insulin/405). Body composition and bone mineral density were measured using dual energy X-ray absorptiometry(DXA; Hologic QDR 4500, Waltham, MA, United Kingdom). RESULTS Percent trunk fat was associated inversely with whole body bone mineral content(BMC), whereas HOMA-IR was associated positively with whole body BMC.CONCLUSION Our results suggest that abdominal adiposity may have an adverse effect on whole body bone parameters and that this effect is not mediated by insulin resistance.
基金The Spanish Association of Pediatrics Foundation supported the study (INVEST-AEP-2018 09-18 02-19).
文摘Since severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)emerged,we have followed this pandemic with great interest and concern from Europe(Navarra-Spain)and the United States(Boston-Massachusetts).We were expecting children to present to emergency departments with the“classical COVID-19 symptoms-triad”such as fever,cough,and a range of respiratory distress[1]and we had learned from countries affected earlier by the virus,that it appeared to be less common and relatively mild in children[2,3].
文摘The World Health Organization(WHO)announced COVID-19 as a global pandemic in March of 2020[1].The COVID-19 pandemic may persist for a long period of time.Global prevention and control becomes a complex and challenging task,and such efforts should be sustained.Although general measures,such as social distancing,face masks,respiratory hygiene and hand sanitization,will bear fruits for decreasing spread of other respiratory illnesses including influenza,the specific prevention through vaccination is a key focus especially in the upcoming winter and spring seasons[2].
