Study on the correlation of serum inflammatory cytokine and insulin-like growth factor related indicators with hypertensive disorder complicating pregnancy

Objective:To explore the correlation of serum inflammatory cytokine and insulin-like growth factor (IGF) related indicators with hypertensive disorder complicating pregnancy (HDP). Methods:A total of 90 patients with HDP who were admitted in our hospital from July, 2015 to July, 2016 for delivery were included in the study and divided into the pregnancy-induced hypertension group (n=43), mild preeclampsia group (n=28), and severe preeclampsia group (n=19). Moreover, 40 healthy puerpera who were admitted in the same period for delivery were served as the control group. The peripheral venous blood before delivery was collected. The immunoturbidimetry was used to detect hs-CRP. The radioimmunoassay was used to detect TNF-α and IL-6. ELISA was used to detect IGF-I, IGF-II, and IGFBP-1.Results:The serum hs-CRP, TNF-α, and IL-6 levels in the pregnancy-induced hypertension group, mild preeclampsia group, and severe preeclampsia group were significantly higher than those in the control group, and were gradually elevated with the further aggravation of the disease. The serum IGF-I and IGF-II levels in the pregnancy-induced hypertension group, mild preeclampsia group, and severe preeclampsia group were significantly lower than those in the control group, while IGFBP-1 level was significantly higher than that in the control group. With the further aggravation of the disease, IGF-I and IGF-II levels were gradually reduced, while IGFBP-1 level was gradually elevated.Conclusions: hs-CRP, TNF-α, IL-6, IGF-Ⅰ, IGF-Ⅱ, and IGFBP-1 are closely associated with the occurrence and development of HDP.

Study on the uterine artery and fetal umbilical artery hemodynamics in patients with HDP

Objective:To explore the uterine artery and fetal umbilical artery hemodynamic change in patients with HDP.Methods:A total of 80 patients with HDP who came to our hospital from July, 2015 to July, 2016 for pregnancy examination were included in the study and served as the observation group, while 80 healthy pregnant women who came for pregnancy examination in the same period were served as the control group. The pregnant women in the two groups were performed with sequential color Doppler ultrasound at gestation 30-40 weeks. The two-dimensional ultrasound apparatus was used to detect the uterine artery and umbilical artery. PI, RI, and S/D were recorded. The fetal BPD, head girth, femur length, and abdominal girth were measured. ELISA was used to detect 8-iso-PGF2α. The immunoturbidimetry was used to detect Cys-C and CRP.Results:The uterine artery PI, RI, and S/D in the observation group were significantly higher than those in the control group. The umbilical artery PI, RI, and S/D in the observation group were significantly higher than those in the control group. The fetal BPD, head girth, femur length, and abdominal girth in the observation group were significantly less than those in the control group. 8-iso-PGF2α, Cys C, and CRP levels in the observation group were significantly higher than those in the control group.Conclusions:The uterine artery and umbilical artery blood flow resistance in patients with HDP are significantly elevated, which can severely affect the placental blood perfusion and fetal growth and development, while the color Doppler ultrasound can provide a non-invasive diagnosis for fetal distress in uterus.