Highly Aligned Ternary Nanofiber Matrices Loaded with MXene Expedite Regeneration of Volumetric Muscle Loss

Current therapeutic approaches for volumetric muscle loss(VML)face challenges due to limited graft availability and insufficient bioactivities.To overcome these limitations,tissue-engineered scaffolds have emerged as a promising alternative.In this study,we developed aligned ternary nanofibrous matrices comprised of poly(lactide-co-ε-caprolactone)integrated with collagen and Ti_(3)C_(2)T_(x)MXene nanoparticles(NPs)(PCM matrices),and explored their myogenic potential for skeletal muscle tissue regeneration.The PCM matrices demonstrated favorable physicochemical properties,including structural uniformity,alignment,microporosity,and hydrophilicity.In vitro assays revealed that the PCM matrices promoted cellular behaviors and myogenic differentiation of C2C12 myoblasts.Moreover,in vivo experiments demonstrated enhanced muscle remodeling and recovery in mice treated with PCM matrices following VML injury.Mechanistic insights from next-generation sequencing revealed that MXene NPs facilitated protein and ion availability within PCM matrices,leading to elevated intracellular Ca^(2+)levels in myoblasts through the activation of inducible nitric oxide synthase(i NOS)and serum/glucocorticoid regulated kinase 1(SGK1),ultimately promoting myogenic differentiation via the m TOR-AKT pathway.Additionally,upregulated i NOS and increased NO–contributed to myoblast proliferation and fiber fusion,thereby facilitating overall myoblast maturation.These findings underscore the potential of MXene NPs loaded within highly aligned matrices as therapeutic agents to promote skeletal muscle tissue recovery.

Multi-Objective Optimal Design of the Wind-Wave Hybrid Platform with the Coupling Interaction

An offshore wind-wave hybrid platform could consistently and cost-effectively supply renewable power.A multi-objective optimization process is proposed for a hybrid platform with hydrodynamic coupling interaction.The effects of various critical structural parameters,spacing values,and wave directions are studied for higher energy capture and offshore platform stability.Approximation models of various key parameters are established to optimize the hybrid system,with the objects of the power capture width ratio and the stability index of the platform.The optimization results are affected by the hydrodynamic coupling interaction,with a tendency to affect the higher frequency of hydrodynamic performance in the hybrid system.After the optimization,an appropriate spacing value effectively improves energy capture performance.The optimal array distance D_(Ff),D_(Fp),the optimal structural parameters R_(p),r_(p),d_(f),r_(f),and B_(PTO)are 11.57,12.75,5.1,3.3,1.5,6.5 m,and 80436 Nm s^(-1),respectively.The peak value of the wave energy converter capture width ratio in the hybrid system increases by almost 50%,with a 54%decrease in the stability index.

Optimizing loading path and die linetype of large length-to-diameter ratio metal stator screw lining hydroforming

In order to meet the high temperature environment requirement of deep and superdeep well exploitation, a technology of large length-to-diameter ratio metal stator screw lining meshing with rotor is presented. Based on the elastic-plasticity theory, and under the consideration of the effect of tube size, material mechanical parameters, friction coefficient and loading paths, the external pressure plastic forming mechanical model of metal stator screw lining is established, to study the optimal loading path of metal stator lining tube hydroforming process. The results show that wall thickness reduction of the external pressure tube hydroforming(THF) is about 4%, and three evaluation criteria of metal stator screw lining forming quality are presented: fillet stick mold coefficient, thickness relative error and forming quality coefficient. The smaller the three criteria are, the better the forming quality is.Each indicator has a trend of increase with the loading rate reducing, and the adjustment laws of die arc transition zone equidistance profile curve are acquired for improving tube forming quality. Hence, the research results prove the feasibility of external pressure THF used for processing high-accuracy large length-to-diameter ratio metal stator screw lining, and provide theoretical basis for designing new kind of stator structure which has better performance and longer service life.

Mechanism analysis and process optimization of sand and plug removal with rotating jet in horizontal well

In the view of the problems existing in horizontal well,such as sand depositing and cleaning difficulty of borehole,a technology with rotating jet suitable to resolution of the problems was presented.Based on liquid solid two-phase flow theory,the analyses on the sand movement law and the swirling field influential factors were conducted.Results show that:1) With the increasing of displacement in horizontal section annulus,swirling field strength increases,and when the displacement is constant,the closer from the nozzle,the stronger the swirling field strength is;2) Head rotating speed and liquid viscosity have little influence on the swirling field strength,but the sand-carrying rate of fluid can increase by increasing liquid viscosity in a certain range;3) Rotating the string and reducing its eccentricity in annulus are conducive for sand migration in the annulus;4) The sand can be suspended and accelerated again and the swirling field strength is enhanced by the helix agitator.Hence,the research results provide the theoretical basis for the design and application of rotating jet tool.

EFFECT OF FABRICATION ON HIGH CYCLE FATIGUE PROPERTIES OF COPPER THIN FILMS

The influence of fabrication on the tensile and fatigue behavior of copper films manufactured by 3 kinds of fabrication methods was investigated. The tensile and high cycle fatigue tests were performed using the test machine developed by authors. Young＇s moduli （72, 71 and 69 GPa, respectively） are lower than the literature values （108-145 GPa）, while the yield strengths were as high as 358, 350 and 346 MPa, respectively and the ultimate strengths as 462, 456 and 446 MPa, respectively. There is not much difference in the tensile properties of the 3 kinds of films. There is little difference in the fatigue properties of the 3 kinds of films but one of them has shorter fatigue life than others in high cycle region and longer fatigue life than others in low cycle region.

含有不确定参数结构的数据驱动载荷识别方法

动载荷识别在结构设计和优化中起着至关重要的作用目前的大多数研究都集中在确定性结构上.然而,实际工程结构中的结构参数是未知的.不确定参数的存在会导致载荷识别结果与实际载荷值之间的误差,因此研究不确定结构的动载荷识别问题至关重要的.本文针对含有不确定参数的结构,提出了一种数据驱动的动载荷识别方法.首先,将不确定参数由一组闭区间向量表征.然后引入卷积神经网络(CNN)对未知载荷区间进行重构.将区间分析理论与泰勒展开相结合,得到了监督载荷的上下边界,并将其用作训练样本.最后,训练后的CNN模型直接识别未知载荷区间的边界.仿真结果表明,该方法具有较高的载荷识别精度和对噪声的鲁棒性.我们构造了一个简支梁结构进行实验,以进一步验证所提出方法在工程中的可行性.此外,我们还讨论了测量点分布和样本数量对识别精度的影响,这有利于在工程实践中的应用。

High-order femtosecond vortices up to the 30th order generated from a powerful mode-locked Hermite-Gaussian laser

Femtosecond vortex beams are of great scientific and practical interest because of their unique phase properties in both the longitudinal and transverse modes,enabling multi-dimensional quantum control of light fields.Until now,generating femtosecond vortex beams for applications that simultaneously require ultrashort pulse duration,high power,high vortex order,and a low cost and compact laser source has been very challenging due to the limitations of available generation methods.Here,we present a compact apparatus that generates powerful high-order femtosecond vortex pulses via astigmatic mode conversion from a mode-locked Hermite-Gaussian Yb:KGW laser oscillator in a hybrid scheme using both the translation-based off-axis pumping and the angle-based non-collinear pumping techniques.This hybrid scheme enables the generation of femtosecond vortices with a continuously tunable vortex order from the 1st up to the 30th order,which is the highest order obtained from any femtosecond vortex laser source based on a mode-locked oscillator.The average powers and pulse durations of all resulting vortex pulses are several hundred milliwatts and<650 fs,respectively.In particular,424-fs 11th-order vortex pulses have been achieved with an average power of 1.6 W,several times more powerful than state-of-the-art oscillator-based femtosecond vortex sources.

Promoting Si-graphite composite anodes with SWCNT additives for half and NCM 811 full lithium ion batteries and assessment criteria from an industrial perspective

Single wall carbon nanotube(SWCNT)additives were formulated into(im-Si-graphite composite electrodes and tested in both half cells and full cells with high nickel cathodes.The critical role of small amount of SWCNT addition(0.2 wt%)was found for significantly improving delithiation capacity,first cycle coulombic efficiency(FCE),and capacity retention.Particularly,Si(10 wt%)-graphite electrode exhibits 560 mAh/g delithiation capacity and 92%FCE at 0.2 C during the first chargedischarge cycle,and 91%capacity retention after 50 cycles(0.5 C)in a half cell.Scanning electron microscope(SEM)was used to illustrate the electrode morphology,compositions and promoting function of the SWCNT additives.In addition,full cells assembled with high nickel-NCM811 cathodes and fim-Si-graphite composite anodes were evaluated for the consistence between half and full cell performance,and the consideration for potential commercial application.Finally,criteria to assess Si-containing anodes are proposed and discussed from an industrial perspective.

Complete characterization of ultrafast optical fields by phase-preserving nonlinear autocorrelation

Nonlinear autocorrelation was one of the earliest and simplest tools for obtaining partial temporal information about an ultrashort optical pulse by gating it with itself.However,since the spectral phase is lost in a conventional autocorrelation measurement,it is insufficient for a full characterization of an ultrafast electric field,requiring additional spectral information for phase retrieval.Here,we show that introducing an intensity asymmetry into a conventional nonlinear interferometric autocorrelation preserves some spectral phase information within the autocorrelation signal,which enables the full reconstruction of the original electric field,including the direction of time,using only a spectrally integrating detector.We call this technique Phase-Enabled Nonlinear Gating with Unbalanced Intensity(PENGUIN).It can be applied to almost any existing nonlinear interferometric autocorrelator,making it capable of complete optical field characterization and thus providing an inexpensive and less complex alternative to methods relying on spectral measurements,such as frequency-resolved optical gating(FROG)or spectral phase interferometry for direct electric-field reconstruction(SPIDER).More importantly,PENGUIN allows the precise characterization of ultrafast fields in non-radiative(e.g.,plasmonic)nonlinear optical interactions where spectral information is inaccessible.We demonstrate this novel technique through simulations and experimentally by measuring the electric field of~6-fs laser pulses from a Ti:sapphire oscillator.The results are validated by comparison with the well-established FROG method.