Analysis on missed diagnosis or misdiagnosis of anomalous origin of left coronary artery from pulmonary artery by echocardiography from one single medical center

Objective To analyze the reasons of missed diagnosis or misdiagnosis on anomalous origin of left coronary artery from pulmonary artery(ALCAPA)by echocardiography.Methods This is a retrospective study.Patients with ALCAPA who underwent surgical treatment in Union Hospital,Tongji Medical College,Huazhong University of Science and Technology from August 2008 to December 2021 were included.

Abnormal striatum functional connectivity in major depressive disorder: a resting state functional magnetic resonance imaging study

Objective To investigate the characteristics of striatum functional connectivity(FC)in patients with major depressive disorder(MDD).Methods Fifty unmedicated patients with MDD and 48 healthy controls underwent resting-state functional magnetic resonance imaging(rsfMRI)scan.Routine preprocessing of rs-fMRI data was performed.The striatum was divided into bilateral inferior ventral striatum,bilateral superior ventral striatum,bilateral dorsal caudate,bilateral dorsal caudal putamen,bilateral dorsal rostral putamen,and bilateral ventral rostral putamen.Whole brain functional connectivity analysis was performed with the above 12 seed points.And significant differences of each seed FC between every two groups were calculated with Two-sample t-test and multiple comparison correction of threshold-free cluster enhancement(TFCE).Finally,correlation analysis was performed between the FC of the brain regions and clinical features(i.e.Hamilton Depression Scale of 24 items(HAMD24)scores).Results In comparison with the control group,the MDD patients significantly decreased FC in the left dorsal caudal putamen and the right superior temporal gyrus(t=-5.46,P<0.008,TFCE correction),the right dorsal rostral putamen and bilateral postcentral gyrus(right t=-4.85,left t=-4.81,P<0.008,TFCE correction)and left precuneus(t=-4.58,P<0.008,TFCE correction).There were no significant correlations between the FC values in these regions and HAMD24 scores(r=0.171,0.002,0.005,0.098;all P<0.05).Conclusion The MDD patients possibly have abnormal FC in the striatum and the superior temporal gyrus,the postcentral gyrus and the precuneus,and it suggests these sensorimoter areas may play an important role in the pathological mechanisms of MDD.

Insular subdivisions functional connectivity in patients with major depressive disorder:a restingstate functional magnetic resonance imaging study

Objective To provide a basic profile of resting-state functional connectivity(FC)in unmedicated patients with major depressive disorder(MDD).Methods Fifty unmedicated patients with MDD and 51 healthy controls underwent the resting-state functional magnetic resonance imaging(rs-fMRI).After preprocessing of rs-fMRI.

Changes of cerebral blood flow perfusion in bipolar disorder patients with suicidal ideation:a resting-state functional magnetic resonance imaging study

Objective To compare the changes of cerebral blood flow (CBF) in bipolar disorder type Ⅱ patients with and without suicidal ideation.Methods Pseudo-continuous arterial spin labelling (pCASL) was examined with resting-state functional magnetic resonance imaging (rs-fMRI) on all subjects,CBF images of bipolar disorder typeⅡ depression with suicidal ideation (n=48),Bipolar Disorder type Ⅱ without suicidal ideation (n=41).

Quantitative analysis of brain metabolites in patients,with non-dementia vascular cognitive impairment and mild cognitive impairment

Objective To investigate metabolite changes in the brain of patients with non-dementia vascular cognitive impairment(VCIND) and mild cognitive impairment(MCI) using magnetic resonance spectroscopy(MRS)

Discussion of grading method of small opacity profusion of pneumoconiosis on CT scans and the corresponding reference images

Objective To explore the CT grading method of small opacity profusion of pneumoconiosis, and draw up the corresponding CT reference film.Methods In December 2019, three hundred thirty-seven cases of pneumoconosis and suspected pneumoconiosis were examined by chest radiography and Computed Tomography(CT) in the same period.

A deformation-based morphometry study on gray matter abnormalities in drug-naive patients with first-onset major depressive disorder

Objective To explore the structural changes of grey matter(GM)in drug-naive patients with first-onset major depressive disorder(MDD)by using deformation-based morphometry(DBM)and the possible imaging biomarkers for early diagnosis of MDD.Methods 3D T_(1)-weighted structural MRI scans were performed on 38 MDD patients and 65 healthy controls(HCs),matched with age and gender.