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Pseudolymphoma (reactive lymphoid hyperplasia) of the liver:A clinical challenge 被引量:8
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作者 Yong Kyong Kwon Reena C Jha +3 位作者 Kambiz Etesami Thomas M Fishbein Metin Ozdemirli Chirag S Desai 《World Journal of Hepatology》 CAS 2015年第26期2696-2702,共7页
Reactive lymphoid hyperplasia(RLH), also known as pseudolymphoma or nodular lymphoid lesion of the liver is an extremely rare condition, and only 51 hepatic RLH cases have been described in the literature since the fi... Reactive lymphoid hyperplasia(RLH), also known as pseudolymphoma or nodular lymphoid lesion of the liver is an extremely rare condition, and only 51 hepatic RLH cases have been described in the literature since the first case was described in 1981. The majority of these cases were asymptomatic and incidentally found through radiological imaging. The precise etiology of hepatic RLH is still unknown, but relative high prevalence of autoimmune disorder in these cases suggests an immune-based liver disorder. Imaging features of hepatic RLH often suggest malignant lesions such as hepatocellular carcinoma and cholangiocarcinoma. In this report, we discuss two cases of hepatic RLH in patients with autoimmune hepatitis. We also present pathologic and magnetic resonance imaging findings, including one case utilizing a hepatocellular contrast agent, Eovist. Definitive diagnosis of hepatic RLH often requires surgical excision. 展开更多
关键词 PSEUDOLYMPHOMA NODULAR LYMPHOID LESION LIVER Magne
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碱性成纤维细胞及角蛋白对丝素蛋白膜改性的实验研究 被引量:1
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作者 刁小娟 赵东旭 +1 位作者 李珺山 陈帼玲 《中华细胞与干细胞杂志(电子版)》 2015年第4期29-32,共4页
目的探讨碱性成纤维细胞生长因子(bFGF)及角蛋白对丝素蛋白膜改性后的生物相容性改变。方法还原法制备水溶性人发角蛋白,用共混法使人发角蛋白与丝素蛋白形成共混膜;化学交联法用bFGF对丝素膜进行表面修饰形成交联膜。通过MTT法及荧光... 目的探讨碱性成纤维细胞生长因子(bFGF)及角蛋白对丝素蛋白膜改性后的生物相容性改变。方法还原法制备水溶性人发角蛋白,用共混法使人发角蛋白与丝素蛋白形成共混膜;化学交联法用bFGF对丝素膜进行表面修饰形成交联膜。通过MTT法及荧光显微镜观察检测3T3细胞在三种丝素基材料上的增殖情况。通过接触角测定,对上述三种材料亲水性进行表征。不同的丝素基材料对细胞增殖的促进情况以及接触角的测定2组间SUV_(max)比较采用两样本t检验。结果制备的人发角蛋白分子量范围在44-66KDa之间,条带清晰。MTT法及显微镜观察表明,含角蛋白40﹪共混膜对细胞生长的促进作用最为明显(0.718±0.03,P<0.05),交联膜次之(0.545±0.022,P<0.05),最后是丝素膜(0.463±0.027,P<0.01)。接触角测定结果表明,共混膜的接触角(17.5±1.6,P<0.01)最小,交联膜(47±1.8,P<0.01)次之,丝素膜的接触角(61±1.5,P<0.05)最大,即共混膜黏附性最好。结论制备的40﹪共混膜具有最强生物相容性,b FGF修饰的丝素蛋白交联膜次之,最后是丝素膜。 展开更多
关键词 成纤维细胞 丝素蛋白 生长因子 角蛋白
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