Imaging of Insulitis in NOD Mice with IL-2-Gd-DTPA and 1.5 T MRI

To explore the possibility to use 1.5 T MRI in imaging of accumulating gadolinium (Gd) into inflamed en- docrine pancreas (insulitis), we compared intravenously delivered IL-2-Gd-DTPA and Gd-DTPA (Magne- vist?) in phenotypically healthy 12 weeks old female non-obese diabetic (NOD) mice. At 1 to 48 h after the injection mice were sacrificed and the pancreas-to-background ratio was determined using MRI. In addition Gd concentration of the pancreas and plasma were measured. The pancreas-to-plasma ratio of Gd was 25-fold 24 h after the i.v. injection of IL-2-Gd-DTPA. At the same time the pancreas-to-background ratio measured with 1.5T MRI was 1.5-times higher in the NOD mice receiving IL-2-Gd-DTPA than Magnevist? (271 ± 37 vs. 183 ± 0,1, P = 0.04) indicating that sufficient differences may exist between IL-2-Gd-DTPA accumulating in the pancreas and in the surrounding tissues to support the use of MRI for imaging of pan- creatic insulitis.

同相位和反相位MR成像快速评价非酒精性脂肪肝的脂肪含量

目的 以^1H-MRS作为参考标准，评价同相位和反相位MR成像在估测非酒精性脂肪肝（NAFLD）病人的肝脏脂肪含量（LFC）中的价值。方法 所有受检者均签署知情同意书，当地伦理委员会也同意开展此项前瞻性研究计划。共有33例NAFLD高风险的2型糖尿病病人[男性23例，女性10例；平均年龄（62．8±8．3）岁，范围48～77岁]接受了1．5T MRI的肝脏^1H-MRS检查及同相位和反相位MRI检查。