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An assessment of racial differences in epidemiological, clinical and psychosocial factors among head and neck cancer patients at the time of surgery
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作者 Anvesh Kompelli Kathleen B.Cartmell +7 位作者 Katherine R.Sterba Anthony J.Alberg Christopher C.Xiao Amit J.Sood Elizabeth Garrett-Mayer Shai J.White-Gilbertson Steven A.Rosenzweig Terry A.Day 《World Journal of Otorhinolaryngology-Head and Neck Surgery》 2020年第1期41-48,共8页
Objective:Racial disparities have been well characterized and African American(AA)patients have 30%lower 5-year survival rates than European Americans(EAs)for head and neck squamous carcinoma(HNSCC).This poorer surviv... Objective:Racial disparities have been well characterized and African American(AA)patients have 30%lower 5-year survival rates than European Americans(EAs)for head and neck squamous carcinoma(HNSCC).This poorer survival can be attributed to a myriad of different factors.The purpose of this study was to characterize AA-EA similarities and differences in sociodemographic,lifestyle,clinical,and psychosocial characteristics in HNSCC patients near the time of surgery.Methods:Setting:Single tertiary care center.Participants:Thirty-nine newly diagnosed,untreated HNSCC patients(n=24 EAs,n=15 AAs)who were to undergo surgery were recruited.Study Design:Cross-sectional study Sociodemographic,lifestyle factors,and disease factors(cancer site,AJCC clinical and pathologic stage,and HPV status)were assessed.Risk factors,leisure time,quality of life and social support were also assessed using validated questionnaires.Exposures:EA and AA patients were similar in the majority of sociodemographic factors assessed.AAs had a higher trend toward pathologically later stage disease compared to EAs and significantly increased time to treatment.Results:EA and AA patients were similar in the majority of sociodemographic factors assessed.AAs had a higher trend toward pathologically later stage disease compared to EAs.AAs also had significantly increased time to treatment(P=0.05).The majority of AA patients(62%)had later stage pathologic disease.AA were less likely to complete high school or college(P=0.01)than their EA counterparts.Additionally,AAs were more likely to report having a gap in health insurance during the past decade(37%vs.15%).Conclusions:This preliminary study demonstrates a similar profile of demographics,clinical and psychosocial characteristics preoperatively for AAs and EAs.Key differences were AAs tending to have later pathologic stage disease,educational status,delays in treatment initiation,and gaps in health insurance. 展开更多
关键词 Head and neck cancer Healthcare disparities Treatment delay Health services Quality care HPV
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地塞米松对肺泡炎大鼠肺内炎性细胞增殖与凋亡的影响 被引量:3
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作者 李惠萍 李霞 +2 位作者 何国钧 易祥华 Charlie Strange 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2002年第9期551-552,共2页
关键词 地塞米松 肺泡炎 肺内炎性细胞增殖 凋亡 影响
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神经胶质细胞的活化和成人听觉损伤后神经再生及自我修复(英文)
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作者 郎海南 《中国医学文摘(耳鼻咽喉科学)》 2013年第4期200-204,共5页
螺旋神经节细胞是将信息从耳蜗神经传递到枢听觉系统的主要传入细胞。施万细胞、卫星细胞和少突胶质细胞等各种神经胶质细胞与外周和中枢神经元信息处理这一活动密切相关。中枢神经系统的神经胶质细胞在脑损伤后调节组织稳态、控制神经... 螺旋神经节细胞是将信息从耳蜗神经传递到枢听觉系统的主要传入细胞。施万细胞、卫星细胞和少突胶质细胞等各种神经胶质细胞与外周和中枢神经元信息处理这一活动密切相关。中枢神经系统的神经胶质细胞在脑损伤后调节组织稳态、控制神经再生起重要作用,但在成人听神经损伤后神经再生和修复过程不为所知。Sox2是一种主要的神经发生调节器,在维持神经干/祖细胞的增殖必不可少。最近在急性螺旋神经节退行性变动物模型中发现在神经元死亡后很快Sox2阳性亚群神经胶质细胞表达BrdU,表明成熟细胞在经历急性耳蜗损伤后可以改变它们的静态表型并重新进入细胞周期。耳蜗病变某些病理条件下,活化的Sox2阳性胶质细胞可能对于听神经再生和自我修复是一个重要的调节物质。 展开更多
关键词 Primary auditory NERVE NEURAL DEGENERATION GLIAL cell activation regeneration NEURAL stem cells
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