Health literacy is critical to improving individual and public health.However,indigenous perceptions of health are largely absent from Western-derived measurements,contributing to disparities in health outcomes betwee...Health literacy is critical to improving individual and public health.However,indigenous perceptions of health are largely absent from Western-derived measurements,contributing to disparities in health outcomes between indigenous and non-indigenous populations.China is the country with the world's largest population and only officially introduced the term"health literacy"in 2008.Current measures of health literacy in China are primarily based on Western-derived constructs,which have been shown to have poor comparability to the unique dual medical system in China.Given its significant importance to health management globally,understanding health perceptions from a traditional Chinese medicine perspective is essential.This review explores the concept and core elements of indigenous health literacy,evaluates the existing definitions and measurement tools as applied to the concept,and proposes a new model of traditional Chinese medicine health literacy.展开更多
The mechanisms underlying autophagic defects in nonalcoholic steatohepatitis(NASH)remain largely unknown.We aimed to elucidate the roles of hepatic cyclooxygenase 1(COX1)in autophagy and the pathogenesis of diet-induc...The mechanisms underlying autophagic defects in nonalcoholic steatohepatitis(NASH)remain largely unknown.We aimed to elucidate the roles of hepatic cyclooxygenase 1(COX1)in autophagy and the pathogenesis of diet-induced steatohepatitis in mice.Human nonalcoholic fatty liver disease(NAFLD)liver samples were used to examine the protein expression of COX1 and the level of autophagy.Cox1^(Δhepa)mice and their wildtype littermates were generated and fed with 3 different NASH models.We found that hepatic COX1 expression was increased in patients with NASH and diet induced NASH mice models accompanied by impaired autophagy.COX1 was required for basal autophagy in hepatocytes and liver specific COX1 deletion exacerbated steatohepatitis by inhibiting autophagy.Mechanistically,COX1 directly interacted with WD repeat domain,phosphoinositide interacting 2(WIPI2),which was crucial for autophagosome maturation.Adeno-associated virus(AAV)-mediated rescue of WIPI2 reversed the impaired autophagic flux and improved NASH phenotypes in Cox1^(Δhepa)mice,indicating that COX1 deletion-mediated steatohepatitis was partially dependent on WIPI2-mediated autophagy.In conclusion,we demonstrated a novel role of COX1 in hepatic autophagy that protected against NASH by interacting with WIPI2.Targeting the COX1 WIPI2 axis may be a novel therapeutic strategy for NASH.展开更多
Background:An increasing number of valid and well-designed trials have demonstrated a positive correlation between visit-to-visit variability(VVV)in systolic blood pressure(SBP)and increased risk of stroke and coronar...Background:An increasing number of valid and well-designed trials have demonstrated a positive correlation between visit-to-visit variability(VVV)in systolic blood pressure(SBP)and increased risk of stroke and coronary heart disease among hypertensive patients.Methods:A cross-sectional study was conducted that involved 74 patients who visited the outpatient clinic at the Tabanan III Primary Health Care Service during April to May 2017.Blood pressure was retrospectively obtained from medical records.VVV was classified as low or high on the basis of the standard deviation of SBP.Antihypertensive medication adherence was expressed as the percentage of days covered,and sodium intake was measured with 24-hour food recall.Bi-variate analysis was performed,followed by multivariate analysis for significant variables.Results:Among the participants,67.6%were female,with a mean(standard deviation[SD])age of 62.70(10.00)years.Blood pressure was measured 4.82±0.78 times during the period,and the mean(SD)SBP was 139.65(10.57)mm Hg.Nonadherence and sodium intake were signifi-cantly higher in the high-VVV group than in the low-VVV group(nonadherence 13.5%vs.37.8%,P=0.033;sodium intake 1278.44±43.02 mg vs.1495.85±45.26 mg,P=0.038).After adjustment for other covariates,the differences remained significant only for nonadherence(model I exp β=3.89[95.0%confidence interval 1.23-12.34,P<0.05],model II expβ=3.9[95.0%confidence interval 1.12-14.15,P<0.05]).The area under the curve was 0.636(P<0.05),with sensitivity of 67.6%and specificity of 51.4%.Conclusion:Nonadherence to antihypertensive medication was significantly associated with higher VVV of SBP.Further study is needed to assess whether improving adherence could reduce VVV and improve cardiovascular outcomes.展开更多
文摘Health literacy is critical to improving individual and public health.However,indigenous perceptions of health are largely absent from Western-derived measurements,contributing to disparities in health outcomes between indigenous and non-indigenous populations.China is the country with the world's largest population and only officially introduced the term"health literacy"in 2008.Current measures of health literacy in China are primarily based on Western-derived constructs,which have been shown to have poor comparability to the unique dual medical system in China.Given its significant importance to health management globally,understanding health perceptions from a traditional Chinese medicine perspective is essential.This review explores the concept and core elements of indigenous health literacy,evaluates the existing definitions and measurement tools as applied to the concept,and proposes a new model of traditional Chinese medicine health literacy.
基金partly supported by National Natural Science Foundation of China(82125026 and 82122009)Natural Science Foundation of Shandong Province(ZR2022QH241 and ZR2020ZD11,China)Seed Fund for Basic Research of University Research Committee of The University of Hong Kong(20161159263,Hong Kong,China)。
文摘The mechanisms underlying autophagic defects in nonalcoholic steatohepatitis(NASH)remain largely unknown.We aimed to elucidate the roles of hepatic cyclooxygenase 1(COX1)in autophagy and the pathogenesis of diet-induced steatohepatitis in mice.Human nonalcoholic fatty liver disease(NAFLD)liver samples were used to examine the protein expression of COX1 and the level of autophagy.Cox1^(Δhepa)mice and their wildtype littermates were generated and fed with 3 different NASH models.We found that hepatic COX1 expression was increased in patients with NASH and diet induced NASH mice models accompanied by impaired autophagy.COX1 was required for basal autophagy in hepatocytes and liver specific COX1 deletion exacerbated steatohepatitis by inhibiting autophagy.Mechanistically,COX1 directly interacted with WD repeat domain,phosphoinositide interacting 2(WIPI2),which was crucial for autophagosome maturation.Adeno-associated virus(AAV)-mediated rescue of WIPI2 reversed the impaired autophagic flux and improved NASH phenotypes in Cox1^(Δhepa)mice,indicating that COX1 deletion-mediated steatohepatitis was partially dependent on WIPI2-mediated autophagy.In conclusion,we demonstrated a novel role of COX1 in hepatic autophagy that protected against NASH by interacting with WIPI2.Targeting the COX1 WIPI2 axis may be a novel therapeutic strategy for NASH.
文摘Background:An increasing number of valid and well-designed trials have demonstrated a positive correlation between visit-to-visit variability(VVV)in systolic blood pressure(SBP)and increased risk of stroke and coronary heart disease among hypertensive patients.Methods:A cross-sectional study was conducted that involved 74 patients who visited the outpatient clinic at the Tabanan III Primary Health Care Service during April to May 2017.Blood pressure was retrospectively obtained from medical records.VVV was classified as low or high on the basis of the standard deviation of SBP.Antihypertensive medication adherence was expressed as the percentage of days covered,and sodium intake was measured with 24-hour food recall.Bi-variate analysis was performed,followed by multivariate analysis for significant variables.Results:Among the participants,67.6%were female,with a mean(standard deviation[SD])age of 62.70(10.00)years.Blood pressure was measured 4.82±0.78 times during the period,and the mean(SD)SBP was 139.65(10.57)mm Hg.Nonadherence and sodium intake were signifi-cantly higher in the high-VVV group than in the low-VVV group(nonadherence 13.5%vs.37.8%,P=0.033;sodium intake 1278.44±43.02 mg vs.1495.85±45.26 mg,P=0.038).After adjustment for other covariates,the differences remained significant only for nonadherence(model I exp β=3.89[95.0%confidence interval 1.23-12.34,P<0.05],model II expβ=3.9[95.0%confidence interval 1.12-14.15,P<0.05]).The area under the curve was 0.636(P<0.05),with sensitivity of 67.6%and specificity of 51.4%.Conclusion:Nonadherence to antihypertensive medication was significantly associated with higher VVV of SBP.Further study is needed to assess whether improving adherence could reduce VVV and improve cardiovascular outcomes.
