Oral administration of dibutyryl adenosine cyclophosphate improved growth performance in weaning piglets by enhancing lipid fatty acids metabolism

Dibutyryl adenosine cyclophosphate(dbc AMP-Ca), an analog of cyclic adenosine monophosphate(c AMP), plays greater roles in regulating physiological activities and energy metabolism than c AMP. The aim of this study was to investigate the effect of oral administration of dbc AMP-Ca on growth performance and fatty acids metabolism in weaning piglets. A total of 14 early weaning piglets(7 ± 1 d of age,3.31 ± 0.09 kg, Landrace ? Large White ? Duroc) were randomly divided into 2 groups: control group and dbc AMP-Ca group, and the piglets received 7 m L of 0.9% Na Cl or 1.5 mg dbc AMP-Ca dissolved in 7 m L of 0.9% Na Cl per day for 10 d, respectively. The results showed that the average daily gain(ADG)increased by 109.17%(P < 0.05) in the dbc AMP-Ca group compared with the control group. Besides,dbc AMP-Ca significantly decreased blood high density lipoprotein cholesterol(HDLC) concentration(P < 0.05) and significantly increased blood low density lipoprotein cholesterol(LDLC) concentration(P < 0.05) compared with the control group. Further, liver C18:2 n6 t content significantly increased in dbc AMP-Ca group(P < 0.05) compared with the control group. With the increase of C18:2 n6 t content,the m RNA expression levels of peroxisome proliferator-activated receptor a(PPARa) and hormone sensitive glycerol three lipase(HSL), of which genes are related to lipid metabolism, were also significantly increased(P < 0.05 or P < 0.01). All of the results indicated that dbc AMP-Ca improved the ADG, which was probably done by regulating fatty acids metabolism in the liver of weaning piglets.