Objective: To investigate the effect of group psychological intervention on oxidative stress, apoptosis and inflammatory response in patients with schizophrenia. Methods: A total of 80 patients with schizophrenia who ...Objective: To investigate the effect of group psychological intervention on oxidative stress, apoptosis and inflammatory response in patients with schizophrenia. Methods: A total of 80 patients with schizophrenia who received hospitalization in the hospital between September 2014 and October 2016 were collected and divided into control group (n=40) and observation group (n=40) according to the random number table method. Control group received routine clinical intervention, the observation group received group psychological intervention on the basis of conventional intervention, and the differences in serum contents of oxidative stress indicators, apoptosis molecules and inflammatory factors were compared between the two groups of patients before and after intervention. Results: Before intervention, the differences in serum levels of oxidative stress indexes, apoptosis molecules and inflammatory factors were not statistically significant between the two groups of patients. After intervention, serum SOD and bcl-2 levels of both groups of patients were higher than those before intervention while MDA, bax, Caspace-3, Fas, IL-1β, IL-6 and TNF-α levels were lower than those before intervention, and serum SOD and bcl-2 levels of observation group were higher than those of control group while MDA, bax, Caspace-3, Fas, IL-1β, IL-6 and TNF-α levels were lower than those of control group. Conclusion: Group psychological intervention can effectively inhibit the systemic oxidative stress and inflammatory response, and reduce the process of apoptosis in patients with schizophrenia.展开更多
文摘Objective: To investigate the effect of group psychological intervention on oxidative stress, apoptosis and inflammatory response in patients with schizophrenia. Methods: A total of 80 patients with schizophrenia who received hospitalization in the hospital between September 2014 and October 2016 were collected and divided into control group (n=40) and observation group (n=40) according to the random number table method. Control group received routine clinical intervention, the observation group received group psychological intervention on the basis of conventional intervention, and the differences in serum contents of oxidative stress indicators, apoptosis molecules and inflammatory factors were compared between the two groups of patients before and after intervention. Results: Before intervention, the differences in serum levels of oxidative stress indexes, apoptosis molecules and inflammatory factors were not statistically significant between the two groups of patients. After intervention, serum SOD and bcl-2 levels of both groups of patients were higher than those before intervention while MDA, bax, Caspace-3, Fas, IL-1β, IL-6 and TNF-α levels were lower than those before intervention, and serum SOD and bcl-2 levels of observation group were higher than those of control group while MDA, bax, Caspace-3, Fas, IL-1β, IL-6 and TNF-α levels were lower than those of control group. Conclusion: Group psychological intervention can effectively inhibit the systemic oxidative stress and inflammatory response, and reduce the process of apoptosis in patients with schizophrenia.
