In recent work,we have shown that cell senescence of mouse fibroblasts in vitro associates with a build-up of cryptic exons in selected mRNAs,whose level is usually controlled by the activity of TAR DNA binding protei...In recent work,we have shown that cell senescence of mouse fibroblasts in vitro associates with a build-up of cryptic exons in selected mRNAs,whose level is usually controlled by the activity of TAR DNA binding protein of 43 kDa(Tdp-43)(Torres et al.,2022).In vivo,we also found traits of cell senescence in the motor neuron disease model achieved by overexpressing SOD-G93A,the SOD1 gene(harboring a single amino acid substitution of glycine to alanine at codon 93).展开更多
基金the Instituto de Salud CarlosⅢ(PI 17-000134,PI 20-0155)to MPOthe Generalitat de Catalunya 2017SGR696 to RP+2 种基金a"Margarita Salas"fellow from the Spanish Ministry of Universities[Financed by European Union-NextGenerationEl funds]a FUNDELA Grant,RedELA-Plataforma Investigación and the FundacióMiquel Valls(Jack Van den Hoek donation)(to MPO)FEDER funds are acknowledged("A way to make Europe")(to MPO)。
文摘In recent work,we have shown that cell senescence of mouse fibroblasts in vitro associates with a build-up of cryptic exons in selected mRNAs,whose level is usually controlled by the activity of TAR DNA binding protein of 43 kDa(Tdp-43)(Torres et al.,2022).In vivo,we also found traits of cell senescence in the motor neuron disease model achieved by overexpressing SOD-G93A,the SOD1 gene(harboring a single amino acid substitution of glycine to alanine at codon 93).
