Background Women who had delivered a macrosomic newborn will have a higher risk to deliver another macrosomia.We aimed to examine the recurrence risk of macrosomia in the subsequent pregnancy and the implications in l...Background Women who had delivered a macrosomic newborn will have a higher risk to deliver another macrosomia.We aimed to examine the recurrence risk of macrosomia in the subsequent pregnancy and the implications in long-term child health.Methods Data from the Collaborative Perinatal Project,a longitudinal birth cohort with 54,371 singleton births,were used.401 recurrent macrosomic infants (macro-macro) and 1327 normal weight babies with a macrosomia in the last pregnancy (macro-normal) were selected to explore risk factors for recurrent macrosomia.Furthermore,768 newly onset macrosomia with normal birthweight infant in previous pregnancies (normal-macro) were identified to examine long-term health effects of recurrent macrosomia.Results The recurrent rate of macrosomia was 23.2% [95% confidence interval (CI) 21.2%,25.2%].White race,higher pre-pregnant body mass index (BMI),more gestational weight gain,male infant and more prior macrosomic infants were significant risk factors for recurrent macrosomia.At 4 years of age,recurrent macrosomic infants had a higher BMI (16.7 vs.16.1 kg/m2,adjusted fβ:0.36,95% CI:0.12,0.60) and a higher risk of overweight and obesity (adjusted OR:1.56,95% CI:1.10,2.23) than infants with normal birthweight after a previous macrosomic sibling.There was no significant difference between recurrent macrosomia and newly onset macrosomia in child outcomes after adjustment for covariates.Conclusions Fetal macrosomia has a high recurrence rate in the following pregnancy.Higher maternal pre-pregnant BMI and gestational weight gain are still important risk factors for recurrence of macrosomia,which in turn increases the risk for childhood obesity.展开更多
文摘Background Women who had delivered a macrosomic newborn will have a higher risk to deliver another macrosomia.We aimed to examine the recurrence risk of macrosomia in the subsequent pregnancy and the implications in long-term child health.Methods Data from the Collaborative Perinatal Project,a longitudinal birth cohort with 54,371 singleton births,were used.401 recurrent macrosomic infants (macro-macro) and 1327 normal weight babies with a macrosomia in the last pregnancy (macro-normal) were selected to explore risk factors for recurrent macrosomia.Furthermore,768 newly onset macrosomia with normal birthweight infant in previous pregnancies (normal-macro) were identified to examine long-term health effects of recurrent macrosomia.Results The recurrent rate of macrosomia was 23.2% [95% confidence interval (CI) 21.2%,25.2%].White race,higher pre-pregnant body mass index (BMI),more gestational weight gain,male infant and more prior macrosomic infants were significant risk factors for recurrent macrosomia.At 4 years of age,recurrent macrosomic infants had a higher BMI (16.7 vs.16.1 kg/m2,adjusted fβ:0.36,95% CI:0.12,0.60) and a higher risk of overweight and obesity (adjusted OR:1.56,95% CI:1.10,2.23) than infants with normal birthweight after a previous macrosomic sibling.There was no significant difference between recurrent macrosomia and newly onset macrosomia in child outcomes after adjustment for covariates.Conclusions Fetal macrosomia has a high recurrence rate in the following pregnancy.Higher maternal pre-pregnant BMI and gestational weight gain are still important risk factors for recurrence of macrosomia,which in turn increases the risk for childhood obesity.
