The lymphatic vasculature forms an organized network that covers the whole body and is involved in fluid homeostasis,metabolite clearance,and immune surveillance.The recent identification of functional lymphatic vesse...The lymphatic vasculature forms an organized network that covers the whole body and is involved in fluid homeostasis,metabolite clearance,and immune surveillance.The recent identification of functional lymphatic vessels in the meninges of the brain and the spinal cord has provided novel insights into neurophysiology.They emerge as major pathways for fluid exchange.The abundance of immune cells in lymphatic vessels and meninges also suggests that lymphatic vessels are actively involved in neuroimmunity.The lymphatic system,through its role in the clearance of neurotoxic proteins,autoimmune cell infiltration,and the transmission of pro-inflammatory signals,participates in the pathogenesis of a variety of neurological disorders,including neurodegenerative and neuroinflammatory diseases and traumatic injury.Vascular endothelial growth factor C is the master regulator of lymphangiogenesis,a process that is critical for the maintenance of central nervous system homeostasis.In this review,we summarize current knowledge and recent advances relating to the anatomical features and immunological functions of the lymphatic system of the central nervous system and highlight its potential as a therapeutic target for neurological disorders and central nervous system repair.展开更多
Glaucoma as an irreversible blinding opioid neuropathy disease, its blindness rate is the second only after cataract in the world. The optic cup-to-disc ratio(CDR) is generally considered to be an important clinical i...Glaucoma as an irreversible blinding opioid neuropathy disease, its blindness rate is the second only after cataract in the world. The optic cup-to-disc ratio(CDR) is generally considered to be an important clinical indicator for judging the severity of glaucoma by ophthalmologists from retinal fundus image. In this letter, we propose an automatic CDR measurement method that consists of a novel optic disc localization method and a simultaneous optic disc and cup segmentation network based on the improved U shape deep convolutional neural network. Experimental results demonstrate that the proposed method can achieve superior performance when compared with other existing methods. Thus, our method can be used as a powerful tool for glaucoma-assisted diagnosis.展开更多
基金supported by the Key Program of the National Natural Science Foundation of ChinaNo.82030071+1 种基金the Science and Technology Major Project of ChangshaNo.kh2103008 (both to JZH)
文摘The lymphatic vasculature forms an organized network that covers the whole body and is involved in fluid homeostasis,metabolite clearance,and immune surveillance.The recent identification of functional lymphatic vessels in the meninges of the brain and the spinal cord has provided novel insights into neurophysiology.They emerge as major pathways for fluid exchange.The abundance of immune cells in lymphatic vessels and meninges also suggests that lymphatic vessels are actively involved in neuroimmunity.The lymphatic system,through its role in the clearance of neurotoxic proteins,autoimmune cell infiltration,and the transmission of pro-inflammatory signals,participates in the pathogenesis of a variety of neurological disorders,including neurodegenerative and neuroinflammatory diseases and traumatic injury.Vascular endothelial growth factor C is the master regulator of lymphangiogenesis,a process that is critical for the maintenance of central nervous system homeostasis.In this review,we summarize current knowledge and recent advances relating to the anatomical features and immunological functions of the lymphatic system of the central nervous system and highlight its potential as a therapeutic target for neurological disorders and central nervous system repair.
基金Project(2018AAA0102102)supported by the National Science and Technology Major Project,ChinaProject(2017WK2074)supported by the Planned Science and Technology Project of Hunan Province,China+1 种基金Project(B18059)supported by the National 111 Project,ChinaProject(61702559)supported by the National Natural Science Foundation of China。
基金supported by the National Natural Science Foundation of China(Nos.61502537 and 61573380)the Hunan Provincial Natural Science Foundation of China(Nos.2018JJ3681 and 2016JJ2150)+3 种基金the Open Project Fund of Key Lab of Digital Signal and Image Processing of Guangdong Province(No.2018GDDSIPL-01)the Mutual Creation Project for Teachers and Students(No.2018gczd022)the 111 Project(No.B18059)the Fundamental Research Funds for the Central Universities of Central South University(No.2018zzts576)
文摘Glaucoma as an irreversible blinding opioid neuropathy disease, its blindness rate is the second only after cataract in the world. The optic cup-to-disc ratio(CDR) is generally considered to be an important clinical indicator for judging the severity of glaucoma by ophthalmologists from retinal fundus image. In this letter, we propose an automatic CDR measurement method that consists of a novel optic disc localization method and a simultaneous optic disc and cup segmentation network based on the improved U shape deep convolutional neural network. Experimental results demonstrate that the proposed method can achieve superior performance when compared with other existing methods. Thus, our method can be used as a powerful tool for glaucoma-assisted diagnosis.
