Anxa2 is the most studied member of the calcium-mediated phospholipid-binding protein family annexins and is a biomarker in cancers.In this review,we listed clinical findings and confirmed the value of Anxa2 in early ...Anxa2 is the most studied member of the calcium-mediated phospholipid-binding protein family annexins and is a biomarker in cancers.In this review,we listed clinical findings and confirmed the value of Anxa2 in early diagnosis and prognostic prediction due to its overexpression and adverse effect on the outcome in most tumors.Anxa2 plays a pivotal role in cancer cell proliferation,migration,invasion,metastasis,and treatment resistance.Improved understanding of its cancer-promoting function might make it an ideal target for cancer therapy.Here,we systematically summarized the mechanism of Anxa2 in regulating epithelialmesenchymal transition(EMT),cytoskeleton dynamicity,cell cycle,apoptosis,angiogenesis,and immunology by using various tumor models.These data emphasize the potential of Anxa2 for targeted intervention in tumors.Altering Anxa2 expression,neutralizing the cell surface Anxa2,or inhibiting its activation,such as through Tyr23 phosphorylation,could be considered based on the regulatory mechanism of Anxa2 in tumor progression.展开更多
基金supported by the National Natural Science Foundation of China (Grant No. 81702992)
文摘Anxa2 is the most studied member of the calcium-mediated phospholipid-binding protein family annexins and is a biomarker in cancers.In this review,we listed clinical findings and confirmed the value of Anxa2 in early diagnosis and prognostic prediction due to its overexpression and adverse effect on the outcome in most tumors.Anxa2 plays a pivotal role in cancer cell proliferation,migration,invasion,metastasis,and treatment resistance.Improved understanding of its cancer-promoting function might make it an ideal target for cancer therapy.Here,we systematically summarized the mechanism of Anxa2 in regulating epithelialmesenchymal transition(EMT),cytoskeleton dynamicity,cell cycle,apoptosis,angiogenesis,and immunology by using various tumor models.These data emphasize the potential of Anxa2 for targeted intervention in tumors.Altering Anxa2 expression,neutralizing the cell surface Anxa2,or inhibiting its activation,such as through Tyr23 phosphorylation,could be considered based on the regulatory mechanism of Anxa2 in tumor progression.
