AIM: Ets1 proto-oncogene is a transcription factor involved in the activation of several genes of tumor invasion and metastasis. We aimed to determine the relationship between the extent and intensity of Ets1 expressi...AIM: Ets1 proto-oncogene is a transcription factor involved in the activation of several genes of tumor invasion and metastasis. We aimed to determine the relationship between the extent and intensity of Ets1 expression and patients'' clinicopathological factors in gastric carcinoma. METHODS: Immunohistochemical analysis was performed for gastric tumor paraffin-embedded sections, followed by image analysis. RESULTS: Ets1 was not expressed in the normal gastric epithelium and its surrounding cells. The percentage of Ets1 expressing cells detected increased significantly in both epithelial tumor and stromal cells from high T classification, lymph node metastasis positive, clinical advanced-stage groups (P<0.05). The level of Etsl staining in epithelial tumor cells also reflected the degree of cell differentiation. The percentage of epithelial and stromal cells expressing Ets1 was significantly correlated with the presence of lymph node metastasis (P=0.014 and P=0.O01 respectively). Ets1 expression was not observed in tissue samples from patients with benign gastric ulcers.CONCLUSION: Ets1 protein expression in epithelial tumor cells reflects the degree of differentiation, and the percentage of Etsl positive tumor and stromal cells correlates with lymph node metastasis. Thus Etsl is a valuable marker of malignant potential in terms of invasiveness and metastasis of gastric carcinoma. It is also possible that inhibition of Etsl is a potential avenue for therapy in gastric cancer.展开更多
A substantial body of work exists here that describe the relationship between the microstructure, ingot processing and fabrication and mechanical properties of molybdenum sheet after cross rolling process. The objecti...A substantial body of work exists here that describe the relationship between the microstructure, ingot processing and fabrication and mechanical properties of molybdenum sheet after cross rolling process. The objective of this study is to clarify how much the crossing rolling process procedure affects the microstructure, texture and mechanical property of this type of materials. This experiment begins from the power metallurgy to the final molybdenum strip (0.15mmxlOOmmx2000mm) through the cross rolling processing procedure. As a result, good mechanical property, improved elongation, enhanced ductility for further process, such as deep drawing and punching, and the reduced difference of the strength and plasticity between the parallel to rolling direction and perpendicular to rolling direction are achieved by the cross rolling processing procedure. According to discussing all the details about this experiment, it is confirmed that cross rolling molybdenum sheet can provide a concise and comprehensive explanation of processes and can guarantee the optical mechanical property and suitable for large production.展开更多
The paper presented here reports an appropriate static heat treatment and analyses the microstructure with different partially recrystallized annealing temperatures of cross-rolled molybdenum sheet in order to improve...The paper presented here reports an appropriate static heat treatment and analyses the microstructure with different partially recrystallized annealing temperatures of cross-rolled molybdenum sheet in order to improve mechanical property of this type of materials and reduce anisotropy at the same time for perspective application. Five different temperature ranges are chosen in this experiment. The samples of a cross-rolled molybdenum sheet are obtained through powder metallurgy, forged ingots and hot or cold rolled sheet. A period of first-stage annealing at 800°C for one hour is not qualified for the further processing because of bad plasticity, working hardening and crack on the surface. The appropriate second-stage annealing temperature at 950°C for one hour is chosen for improving the elongation and reduces yield strength. The results show that this appropriate partially recrystallized annealing treatment has achieved the ideal grain size and mechanical properties when it is compared with the other four different temperatures with the same second-stage annealing conditions.展开更多
The multiglycosides of Tripterygium wilfordii Hook. f. (GTW) is a Chinese herb medicine used traditionally for the treatment of rheumatoid arthritis, chronic nephritis and some skin diseases. It has been recently show...The multiglycosides of Tripterygium wilfordii Hook. f. (GTW) is a Chinese herb medicine used traditionally for the treatment of rheumatoid arthritis, chronic nephritis and some skin diseases. It has been recently shown to cause infertility in men, male rats展开更多
Objective Fibrin deposition combined with glomerular epithelial cell proliferation and monocyte/macrophage infiltration is involved in the pathogenesis of crescentic glomerulonephritis and results from local thrombin ...Objective Fibrin deposition combined with glomerular epithelial cell proliferation and monocyte/macrophage infiltration is involved in the pathogenesis of crescentic glomerulonephritis and results from local thrombin generation.In addition to its effect on procoagulation and fibrinolysis,thrombin exerts many cellular effects through a functional thrombin receptor,protease-activated receptor-1(PAR-1).The paper is To determine the role of PAR-1 in the pathogenesis of crescentic glomerulonephritis.Methods wild type and PAR-1 knockout mice in an accelerated model of anti-glomerular basement menbrane antibody nephritis were studied.Results The wild type mice exhibited severe glomerular injury 10 days after injection of sheep anti-mouse glomerular besement membrane antibody,such as thrombus formation,extracapillary proiferation as well as renal failure.APR-1 knockout mice showed significant protection from crescentic glomerulonephritis.Conclusion PAR-1 plays a critical role in the pathogenesis of crescentic glomerulonephritis and may be a new target for therapeutic intervention.展开更多
One remarkable feature of wavelet decomposition is that the waveletcoefficients are localized, and any singularity in the input signals can only affect the waveletcoefficients at the point near the singularity. The lo...One remarkable feature of wavelet decomposition is that the waveletcoefficients are localized, and any singularity in the input signals can only affect the waveletcoefficients at the point near the singularity. The localized property of the wavelet coefficientsallows us to identify the singularities in the input signals by studying the wavelet coefficients atdifferent resolution levels. This paper considers wavelet-based approaches for the detection ofoutliers in time series. Outliers are high-frequency phenomena which are associated with the waveletcoefficients with large absolute values at different resolution levels. On the basis of thefirst-level wavelet coefficients, this paper presents a diagnostic to identify outliers in a timeseries. Under the null hypothesis that there is no outlier, the proposed diagnostic is distributedas a χ_1~2. Empirical examples are presented to demonstrate the application of the proposeddiagnostic.展开更多
The problem of finding optimum semijoin sequ4ence of an arbitrary query under linear cost function for the transmission cost is NP.hard.Hence heuristic algorithms with desirable properties are explored.In this paper f...The problem of finding optimum semijoin sequ4ence of an arbitrary query under linear cost function for the transmission cost is NP.hard.Hence heuristic algorithms with desirable properties are explored.In this paper four properties of semijoin programs for distributed query processing are identified,The use of these properties in constructing semijoin sequence is justified.An existing algorithm is modified incorporating these properties.Empirical comparison with existing algorithms shows the superiority of the proposed algorithm.展开更多
Competition based neural networks have been used to solve the generalized assignment problem andthe quadratic assignment problem.Both problems are very difficult and are ε approximation complete.Theneural network app...Competition based neural networks have been used to solve the generalized assignment problem andthe quadratic assignment problem.Both problems are very difficult and are ε approximation complete.Theneural network approach has yielded highly competitive performance and good performance for thequadratic assignment problem.These neural networks are guaranteed to produce feasible solutions.展开更多
文摘AIM: Ets1 proto-oncogene is a transcription factor involved in the activation of several genes of tumor invasion and metastasis. We aimed to determine the relationship between the extent and intensity of Ets1 expression and patients'' clinicopathological factors in gastric carcinoma. METHODS: Immunohistochemical analysis was performed for gastric tumor paraffin-embedded sections, followed by image analysis. RESULTS: Ets1 was not expressed in the normal gastric epithelium and its surrounding cells. The percentage of Ets1 expressing cells detected increased significantly in both epithelial tumor and stromal cells from high T classification, lymph node metastasis positive, clinical advanced-stage groups (P<0.05). The level of Etsl staining in epithelial tumor cells also reflected the degree of cell differentiation. The percentage of epithelial and stromal cells expressing Ets1 was significantly correlated with the presence of lymph node metastasis (P=0.014 and P=0.O01 respectively). Ets1 expression was not observed in tissue samples from patients with benign gastric ulcers.CONCLUSION: Ets1 protein expression in epithelial tumor cells reflects the degree of differentiation, and the percentage of Etsl positive tumor and stromal cells correlates with lymph node metastasis. Thus Etsl is a valuable marker of malignant potential in terms of invasiveness and metastasis of gastric carcinoma. It is also possible that inhibition of Etsl is a potential avenue for therapy in gastric cancer.
文摘A substantial body of work exists here that describe the relationship between the microstructure, ingot processing and fabrication and mechanical properties of molybdenum sheet after cross rolling process. The objective of this study is to clarify how much the crossing rolling process procedure affects the microstructure, texture and mechanical property of this type of materials. This experiment begins from the power metallurgy to the final molybdenum strip (0.15mmxlOOmmx2000mm) through the cross rolling processing procedure. As a result, good mechanical property, improved elongation, enhanced ductility for further process, such as deep drawing and punching, and the reduced difference of the strength and plasticity between the parallel to rolling direction and perpendicular to rolling direction are achieved by the cross rolling processing procedure. According to discussing all the details about this experiment, it is confirmed that cross rolling molybdenum sheet can provide a concise and comprehensive explanation of processes and can guarantee the optical mechanical property and suitable for large production.
文摘The paper presented here reports an appropriate static heat treatment and analyses the microstructure with different partially recrystallized annealing temperatures of cross-rolled molybdenum sheet in order to improve mechanical property of this type of materials and reduce anisotropy at the same time for perspective application. Five different temperature ranges are chosen in this experiment. The samples of a cross-rolled molybdenum sheet are obtained through powder metallurgy, forged ingots and hot or cold rolled sheet. A period of first-stage annealing at 800°C for one hour is not qualified for the further processing because of bad plasticity, working hardening and crack on the surface. The appropriate second-stage annealing temperature at 950°C for one hour is chosen for improving the elongation and reduces yield strength. The results show that this appropriate partially recrystallized annealing treatment has achieved the ideal grain size and mechanical properties when it is compared with the other four different temperatures with the same second-stage annealing conditions.
文摘The multiglycosides of Tripterygium wilfordii Hook. f. (GTW) is a Chinese herb medicine used traditionally for the treatment of rheumatoid arthritis, chronic nephritis and some skin diseases. It has been recently shown to cause infertility in men, male rats
文摘Objective Fibrin deposition combined with glomerular epithelial cell proliferation and monocyte/macrophage infiltration is involved in the pathogenesis of crescentic glomerulonephritis and results from local thrombin generation.In addition to its effect on procoagulation and fibrinolysis,thrombin exerts many cellular effects through a functional thrombin receptor,protease-activated receptor-1(PAR-1).The paper is To determine the role of PAR-1 in the pathogenesis of crescentic glomerulonephritis.Methods wild type and PAR-1 knockout mice in an accelerated model of anti-glomerular basement menbrane antibody nephritis were studied.Results The wild type mice exhibited severe glomerular injury 10 days after injection of sheep anti-mouse glomerular besement membrane antibody,such as thrombus formation,extracapillary proiferation as well as renal failure.APR-1 knockout mice showed significant protection from crescentic glomerulonephritis.Conclusion PAR-1 plays a critical role in the pathogenesis of crescentic glomerulonephritis and may be a new target for therapeutic intervention.
基金This research is supportea by the National Natural Science Foundation of China (79800012,70171001)
文摘One remarkable feature of wavelet decomposition is that the waveletcoefficients are localized, and any singularity in the input signals can only affect the waveletcoefficients at the point near the singularity. The localized property of the wavelet coefficientsallows us to identify the singularities in the input signals by studying the wavelet coefficients atdifferent resolution levels. This paper considers wavelet-based approaches for the detection ofoutliers in time series. Outliers are high-frequency phenomena which are associated with the waveletcoefficients with large absolute values at different resolution levels. On the basis of thefirst-level wavelet coefficients, this paper presents a diagnostic to identify outliers in a timeseries. Under the null hypothesis that there is no outlier, the proposed diagnostic is distributedas a χ_1~2. Empirical examples are presented to demonstrate the application of the proposeddiagnostic.
文摘The problem of finding optimum semijoin sequ4ence of an arbitrary query under linear cost function for the transmission cost is NP.hard.Hence heuristic algorithms with desirable properties are explored.In this paper four properties of semijoin programs for distributed query processing are identified,The use of these properties in constructing semijoin sequence is justified.An existing algorithm is modified incorporating these properties.Empirical comparison with existing algorithms shows the superiority of the proposed algorithm.
文摘Competition based neural networks have been used to solve the generalized assignment problem andthe quadratic assignment problem.Both problems are very difficult and are ε approximation complete.Theneural network approach has yielded highly competitive performance and good performance for thequadratic assignment problem.These neural networks are guaranteed to produce feasible solutions.
