Epidemiological surveys have recently revealed a high prevalence of chronic musculoskeletal pain in Japan;however, 30% of the patients in the survey were not satisfied with their pain treatment. This indicates that st...Epidemiological surveys have recently revealed a high prevalence of chronic musculoskeletal pain in Japan;however, 30% of the patients in the survey were not satisfied with their pain treatment. This indicates that standard strategies in the management of chronic pain are poorly shared among physicians in Japan. Herein we report a case of a patient with intractable chronic pain who is a skilled orthopaedic physician. A 43-year-old man who was a skilled orthopaedic surgeon presented at our center complaining of severe buttock pain especially around the right hip region for more than three years. At begging of pain onset, he was diagnosed with femoacetabular impingement syndrome (FAI) with labral tear. Despite biophysical interventions including twice surgeries and alternative conservative treatment, his pain persisted, and he occasionally had to take a day off work due to the severe pain. Therefore we had to evaluate his pathological condition using a multidimensional approach based on a biopsychosocial model. We had provided him with cognitive behavioral therapy (CBT) approach, and simultaneously suggestion for short leaving from work. Three months after the start of CBT training, his disabilities had begun to improve. About six months later, he could continue to do his work. Finally, 19 months have passed since we started implementing the CBT approach;he has regained both his previous work-life balance and his health, although the pain has not completely subsided. In conclusion, we think it is important for physicians treating chronic pain to learn the management strategies for chronic pain and to re-consider their management policy when conventional biomedical interventions were not succeeded, even in cases where medication and surgical intervention are warranted.展开更多
Hyaluronan is a widely occurring extracellular matrix molecule,which is not only a supporting structural component,but also an active regulator of cellular functions.The chemophysical and biological properties of hyal...Hyaluronan is a widely occurring extracellular matrix molecule,which is not only a supporting structural component,but also an active regulator of cellular functions.The chemophysical and biological properties of hyaluronan are greatly affected by its molecular size and several hyaluronan-binding proteins,making hyaluronan a fascinating molecule with great functional diversity.This review summarizes our current understanding of the roles of hyaluronan in cardiovascular and nervous system disorders,such as atherosclerosis,myocardial infarction,and stroke,with the aim to provide a foundation for future research and clinical trials.展开更多
文摘Epidemiological surveys have recently revealed a high prevalence of chronic musculoskeletal pain in Japan;however, 30% of the patients in the survey were not satisfied with their pain treatment. This indicates that standard strategies in the management of chronic pain are poorly shared among physicians in Japan. Herein we report a case of a patient with intractable chronic pain who is a skilled orthopaedic physician. A 43-year-old man who was a skilled orthopaedic surgeon presented at our center complaining of severe buttock pain especially around the right hip region for more than three years. At begging of pain onset, he was diagnosed with femoacetabular impingement syndrome (FAI) with labral tear. Despite biophysical interventions including twice surgeries and alternative conservative treatment, his pain persisted, and he occasionally had to take a day off work due to the severe pain. Therefore we had to evaluate his pathological condition using a multidimensional approach based on a biopsychosocial model. We had provided him with cognitive behavioral therapy (CBT) approach, and simultaneously suggestion for short leaving from work. Three months after the start of CBT training, his disabilities had begun to improve. About six months later, he could continue to do his work. Finally, 19 months have passed since we started implementing the CBT approach;he has regained both his previous work-life balance and his health, although the pain has not completely subsided. In conclusion, we think it is important for physicians treating chronic pain to learn the management strategies for chronic pain and to re-consider their management policy when conventional biomedical interventions were not succeeded, even in cases where medication and surgical intervention are warranted.
基金Project supported by the Key Research and Development Program of the Ministry of Science and Technology(No.2017YFC0111902)the Shanghai Natural Science Foundation(No.13ZR1404700),China
文摘Hyaluronan is a widely occurring extracellular matrix molecule,which is not only a supporting structural component,but also an active regulator of cellular functions.The chemophysical and biological properties of hyaluronan are greatly affected by its molecular size and several hyaluronan-binding proteins,making hyaluronan a fascinating molecule with great functional diversity.This review summarizes our current understanding of the roles of hyaluronan in cardiovascular and nervous system disorders,such as atherosclerosis,myocardial infarction,and stroke,with the aim to provide a foundation for future research and clinical trials.
