女篮运动员下肢损伤情况同赤脚与穿鞋状态下最大翻转力矩差别高度相关(英文)

背景:现有文献报告的女子篮球运动员受伤大多是踝关节扭伤,其损伤机制存在争议。目前尚无关于赤脚或穿鞋状态下肌肉不平衡及其与损伤严重程度之间关系的调查。本研究的目的是调查穿运动鞋对肌肉力量的作用以及与下肢损伤的关系,尤其针对女篮运动员,因为这一群体踝关节损伤高发。方法:11名大学女子篮球运动员在赛季前接受肌肉内翻及外翻力量测试,即在赤脚和穿鞋状态下,使用等速测力计进行测量。在不同条件下测量倒置与翻转的峰值扭矩、达到峰值的时间以及两种条件下从翻转到峰值的强度百分比。在赛季中记录她们的下肢损伤并按严重程度排名。用斯皮尔曼Rho相关系数(ρ)(a水平0.05)测定赤脚与穿鞋状态的峰值扭矩、达到峰值的时间以及强度百分比等级差别与损伤等级之间的关联。结果:受试者在120°/s状态下赤脚与穿鞋时内翻及外翻扭矩峰值的等级差别与其受伤程度等级相关。赛季中持续的运动员受伤程度等级与其赤脚和穿鞋时外翻扭矩峰值成强烈正相关(ρ=0.78,p=0.02)。结论赤脚与穿鞋状态下肌肉平衡差异大很可能导致运动员受伤;缩小赤脚与穿鞋状态下翻转力矩的差异能减小受伤倾向。今后的研究应关注赤脚与穿鞋状态下恢复肌肉力量的效果。

Regenerative potential of targeting glycogen synthase kinase-3 signaling in neural tissues

Multiple roles of glycogen synthase kinase-3（GSK-3）in neural tissues：GSK-3 is a serine/threonine kinase that has two isoforms encoded by two different genes,GSK-3αand GSK-3β,in mammals.GSK-3 has several sites of serine and tyrosine phosphorylation.

A Dual-radiolabel Marker Quantifies Decrease in HT29 Xenograft Hypoxia Induced by Mild Temperature Hyperthermia

Purpose: In this project, we developed novel methods to quantify changes in tumor hypoxia following a mild tempera-ture hyperthermia (MTH) treatment in rat HT29 human colon adenocarcinoma xenograft. Materials and Methods: An exogenous hypoxia marker (IAZGP) was labeled with two radioisotopes of iodine (131I and 123I, respectively) to form two distinct tracers. The two tracers were injected into HT29-bearing nude rats 4-hour before and immediately following 41.5℃, 45-minute mild hyperthermia treatment. The distributions of the two hypoxia tracers were obtained by performing digital autoradiography on tumor sections, and image processing resulted in quantitative information at 50 μm pixel size. Results: Following the hyperthermia treatment, there was a remarkable decrease in hypoxia tracer binding. The average whole tumor hypoxia tracer targeted fraction in five animals changed from 30.3% ± 9.7% to 13.0% ± 5.3% after the hyperthermia treatment (P = 0.001). Detailed pixelby-pixel analysis of the image data revealed a decline in hypoxia tracer uptake after hyperthermia in most regions. However, there was concomitant emergence of some new regions of hypoxia identified by increased tracer uptake. In the control group, the overall hypoxia tracer targeted fraction remained almost constant, with some hypoxic tracer redistribution (putative acute hypoxia) observed. Conclusion: Reoxygenation occurred in the rat HT29 xenograft following MTH treatment. This was evident with preponderance of decreased hypoxia specific tracer uptake on tumor sections. Our methodology might be a useful tool in hypoxia study.

YAP1对颗粒细胞的重编程可导致具间质谱系和浆液性特征的高级别卵巢癌

高级别浆液性卵巢癌(HGSC)是临床中最常见、且恶性程度最高的卵巢癌.深入了解高级别浆液性卵巢癌的起源细胞可对该亚型卵巢癌进行有效预防和早期诊断.最近TCGA和AOCS通过分子分型研究发现了一种具有间充质特征的高级别浆液性卵巢癌亚型,并且表明该亚型是所有新发现的亚型中预后最差的一种,而且目前大家对于这种卵巢癌新亚型的起源细胞一无所知.在研究Hippo信号通路在卵巢颗粒细胞生理和病理中的作用时,意外地发现Hippo信号传导途径的主要效应分子YAP1的高度激活可以诱导具有间质谱系和高可塑性的卵巢颗粒细胞的去分化与重编程,最终导致具有浆液性特征的高级别卵巢癌的发生.本文的研究结果揭示了具间质特征的高级别浆液性卵巢癌的一种潜在起源细胞.