In a recent study published in Nature,Moiseeva and colleagues examined senescent cells,including fibro/adipogenic progenitors(FAPs),muscle stem cells(MuSCs)and macrophages,which generate an inflammatory and fibrotic n...In a recent study published in Nature,Moiseeva and colleagues examined senescent cells,including fibro/adipogenic progenitors(FAPs),muscle stem cells(MuSCs)and macrophages,which generate an inflammatory and fibrotic niche,thus inhibiting the activation of MuSCs and muscle regeneration.1 The researchers developed a method to distinguish endogenous senescent cells and showed the importance of cellular senescence as a potential target for improving muscle regeneration and repair(Fig.1).^(1)展开更多
基金supported by grants from the project funded by National Natural Science Foundation of China(81830062,to Y.G.)Chongqing Fund for Outstanding Youth(CSTB2022NSCQ-JQX0010 to H.M.)+1 种基金China Postdoctoral Science Foundation(2020M673648,to X.K.),Natural Science Foundation of Chongqing(cstc2020jcyjmsxmX0440,to X.K.)Chongqing Postdoctoral Science Special Foundation(to X.K.).
文摘In a recent study published in Nature,Moiseeva and colleagues examined senescent cells,including fibro/adipogenic progenitors(FAPs),muscle stem cells(MuSCs)and macrophages,which generate an inflammatory and fibrotic niche,thus inhibiting the activation of MuSCs and muscle regeneration.1 The researchers developed a method to distinguish endogenous senescent cells and showed the importance of cellular senescence as a potential target for improving muscle regeneration and repair(Fig.1).^(1)
