Rectal neuroendocrine neoplasia(rNEN)are usually small(<10mm),well-differentiated(G1/2)lesions arising from the interface between mucosal and submucosal layers;therefore,polypectomy and standard endoscopic mucosal ...Rectal neuroendocrine neoplasia(rNEN)are usually small(<10mm),well-differentiated(G1/2)lesions arising from the interface between mucosal and submucosal layers;therefore,polypectomy and standard endoscopic mucosal resection(EMR)techniques are usually not curative due to the presence of neoplastic cells on the resection margin,leading to possible tumor recurrence[1].Ligation-assisted EMR and endoscopic submucosal dissection(ESD)have been proposed as treatment of choice in case of lesions<10mm without muscolaris propria involvement[1-3].However,in real practice,most of these lesions undergo standard EMR and are then refereed to tertiary centers in case of incomplete resections[2,3].Pagano et al.[4]recently demonstrated that,in those cases,ESD was indicated for lesions>3mm because of the risk of residual neoplasia.展开更多
文摘Rectal neuroendocrine neoplasia(rNEN)are usually small(<10mm),well-differentiated(G1/2)lesions arising from the interface between mucosal and submucosal layers;therefore,polypectomy and standard endoscopic mucosal resection(EMR)techniques are usually not curative due to the presence of neoplastic cells on the resection margin,leading to possible tumor recurrence[1].Ligation-assisted EMR and endoscopic submucosal dissection(ESD)have been proposed as treatment of choice in case of lesions<10mm without muscolaris propria involvement[1-3].However,in real practice,most of these lesions undergo standard EMR and are then refereed to tertiary centers in case of incomplete resections[2,3].Pagano et al.[4]recently demonstrated that,in those cases,ESD was indicated for lesions>3mm because of the risk of residual neoplasia.
