Hepatic alveolar echinococcosis (HAE) is a lethal infectious disease caused by the larval stage of Echinococcus multilocularis.To date,radical resection combined with albendazole is considered the major treatment for ...Hepatic alveolar echinococcosis (HAE) is a lethal infectious disease caused by the larval stage of Echinococcus multilocularis.To date,radical resection combined with albendazole is considered the major treatment for patients with HAE.However,many patients miss the best time for diagnosis and resection due to patient delay,doctor delay,or long distances to specialized centers.展开更多
Background:In China the highest prevalence of echinococcosis is in Tibet Autonomous Region(TAR).The government has issued documents and implemented comprehensive prevention and control measures focusing on controlling...Background:In China the highest prevalence of echinococcosis is in Tibet Autonomous Region(TAR).The government has issued documents and implemented comprehensive prevention and control measures focusing on controlling the source of infection of echinococcosis.It was very important to understand the implementation and effect of infectious source control measures.The purpose of this study was to examine the implementation of measures to control infectious source(domestic and stray dogs)in TAR and to assess their effectiveness.Methods:We collected data on domestic dog registration and deworming and stray dog sheltering in 74 counties/districts in the TAR from 2017 to 2019.Fecal samples from domestic dogs were collected from randomly selected towns to determine Echinococcus infection in dogs using coproantigen ELISA.We analyzed the data to compare the canine rate of infection between 2016 and 2019.The data analysis was performed by SPSS statistical to compare dog infection rate in 2016 and 2019 by chi-square test,and ArcGIS was used for mapping.Results:From 2017 to 2019,84 stray dog shelters were built in TAR,and accumulatively 446,660 stray or infected dogs were arrested,sheltered,or disposed of.The number of domestic dogs went downward,with an increased registration management rate of 78.4%(2017),88.8%(2018),and 99.0%(2019).Dogs were dewormed 5 times in 2017,12 times in 2018,and 12 times in 2019.The dog infection rate was 1.7%(252/14,584)in 2019,significantly lower than 7.3%(552/7564)from the survey of echinococcosis prevalence in Tibet in 2016(P<0.05).Conclusion:Between 2017 and 2019,the number of stray dogs and infection rate of Echinococcus spp.in domestic dogs decreased significantly,indicating that dogs were effectively controlled as a source of infection in TAR and reflecting a significant decrease in the risk of echinococcosis transmission.展开更多
What is already known about this topic?Existing manual deworming programs launched have made great progress in reducing the Echinococcus infection rate of domestic dogs,but significant challenges remain in scattered n...What is already known about this topic?Existing manual deworming programs launched have made great progress in reducing the Echinococcus infection rate of domestic dogs,but significant challenges remain in scattered nomadic communities inhabiting the Tibetan Plateau.The low deworming frequency and low levels of coverage were responsible for the high infection rate of Echinococcus spp.among dogs.What is added by this report?Smart deworming collars controlled by a remote management system(RMS)was found to increase the deworming frequency and coverage and subsequently reduce the canine infection rates with Echinococcus spp..What are the implications for public health practice?As an innovative tool,smart deworming collars may drive the paradigm shift from manual deworming to smart deworming and stop the transmission of echinococcosis.展开更多
基金supported by a grant from the Non-proft Central Research Institute Fund of Chinese Academy of Medical Sciences (No. 2019PT320004)。
文摘Hepatic alveolar echinococcosis (HAE) is a lethal infectious disease caused by the larval stage of Echinococcus multilocularis.To date,radical resection combined with albendazole is considered the major treatment for patients with HAE.However,many patients miss the best time for diagnosis and resection due to patient delay,doctor delay,or long distances to specialized centers.
文摘Background:In China the highest prevalence of echinococcosis is in Tibet Autonomous Region(TAR).The government has issued documents and implemented comprehensive prevention and control measures focusing on controlling the source of infection of echinococcosis.It was very important to understand the implementation and effect of infectious source control measures.The purpose of this study was to examine the implementation of measures to control infectious source(domestic and stray dogs)in TAR and to assess their effectiveness.Methods:We collected data on domestic dog registration and deworming and stray dog sheltering in 74 counties/districts in the TAR from 2017 to 2019.Fecal samples from domestic dogs were collected from randomly selected towns to determine Echinococcus infection in dogs using coproantigen ELISA.We analyzed the data to compare the canine rate of infection between 2016 and 2019.The data analysis was performed by SPSS statistical to compare dog infection rate in 2016 and 2019 by chi-square test,and ArcGIS was used for mapping.Results:From 2017 to 2019,84 stray dog shelters were built in TAR,and accumulatively 446,660 stray or infected dogs were arrested,sheltered,or disposed of.The number of domestic dogs went downward,with an increased registration management rate of 78.4%(2017),88.8%(2018),and 99.0%(2019).Dogs were dewormed 5 times in 2017,12 times in 2018,and 12 times in 2019.The dog infection rate was 1.7%(252/14,584)in 2019,significantly lower than 7.3%(552/7564)from the survey of echinococcosis prevalence in Tibet in 2016(P<0.05).Conclusion:Between 2017 and 2019,the number of stray dogs and infection rate of Echinococcus spp.in domestic dogs decreased significantly,indicating that dogs were effectively controlled as a source of infection in TAR and reflecting a significant decrease in the risk of echinococcosis transmission.
基金supported by the Ganzi Prefecture Workgroup Projects for Echinococcosis Prevention and Control,China CDC(2016-07,2017-06,2018-02,2019-02)the NHC Key Laboratory of Echinococcosis Prevention and Control Project(Supported by the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences,2019PT320004)the Key R&D Transformation Projects,Qinghai(2020-SF-133).
文摘What is already known about this topic?Existing manual deworming programs launched have made great progress in reducing the Echinococcus infection rate of domestic dogs,but significant challenges remain in scattered nomadic communities inhabiting the Tibetan Plateau.The low deworming frequency and low levels of coverage were responsible for the high infection rate of Echinococcus spp.among dogs.What is added by this report?Smart deworming collars controlled by a remote management system(RMS)was found to increase the deworming frequency and coverage and subsequently reduce the canine infection rates with Echinococcus spp..What are the implications for public health practice?As an innovative tool,smart deworming collars may drive the paradigm shift from manual deworming to smart deworming and stop the transmission of echinococcosis.
