Prognostic stratification of baseline PET metabolic parameters combined with Bcl-2/c-Myc dual expression in patients with primary gastrointestinal diffuse large B-cell lymphoma

Objective To explore whether baseline PET metabolic parameters combined with B-cell lymphoma-2(Bcl-2)/cellular-myelocytomatosis viral oncogene (cMyc) dual expression (DE) can improve the prognostic stratification of patients with primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL).

Efficacy and safety of endoscopic submucosal dissection for circular superficial esophageal cancer

Objective To evaluate the efficacy and safety of endoscopic submucosal dissection(ESD)for circular superficial esophageal cancer.Methods A retrospective analysis was conducted on 74 consecutive casesof circular superficial esophageal squamous cell carcinoma treated with ESD at Nanjing Drum Tower Hospital from January 2015 to December 2019.The success rate of ESD,curative resection rate,incidence of complications,and additional treatment were mainly observed.Results One case was transferred to surgery,and the remaining 73 cases successfully completed ESD treatment.The success rate of ESD was 98.6%.Postoperative pathology of ESD revealed that 39 cases achieved curative resection,with a curative resection rate of 53.4%(39/73).Intraoperative muscle layer injury occurred in 15 cases(20.5%),and intraoperative perforation occurred in 1 case(1.4%).Two cases(2.7%)experienced delayed bleeding,and one case(1.4%)experienced delayed perforation.Eleven cases were lost to follow-up,and the remaining 62 cases received follow-up for 36.4±19.0 months.Among the follow-up cases.

Clinical characteristics and prognostic factors of patients with anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis associated interstitial lung disease

Objective To analyze the clinical characteristics and prognostic factors of patients with anti-melanoma differentiation-associated gene 5(anti-MDA5)-positive dermatomyositis associated interstitial lung disease(DMILD).Methods The patients with MDA5~+DM-ILD who were admitted to Department of Respiratory Medicine,Nanjing Drum Tower Hospital from January 2017 to March 2021 were enrolled.The clinical data and survival information were analyzed retrospectively.

An unusual case of welder＇s siderosis with local massive fibrosis： a case report

Welder＇s siderosis was traditionally described as ＂benign pneumoconiosis＂ because of the absence of associated symptoms, functional impairment or pulmonary fibrosis. Although several authors have reported evidence of fibrosis in the lungs of welders, sJderosJs with local massJve fibrosis has been rarely descrJbed. In this paper, we present a case of Welder＇s siderosis with local massive fibrosis mimicking lung cancer.

Serum cytokine levels in patients with advanced non-small cell lung cancer： correlation with clinical outcome of erlotinib treatment

Background Serum expression of cytokines may provide information about the clinical outcome of advanced non-small cell lung cancer （NSCLC） patients. This study aimed to investigate the relationship between serum cytokine levels and the clinical outcome of erlotinib treatment in a second or third line setting in patients with advanced NSCLC.

Magnetic resonance tracking of endothelial progenitor cells labeled with superparamagnetic iron oxide homing to the site of hepatoma

Objective To track the migration and incorporation of intravenously injected,magnetically labeled endothelial progenitor cells(EPCs)from mouse bone marrow into the blood vessels in a rapidly growing HCC model by micro MR(7.0 T).Methods This study was approved by the Institutional Committee on Animal Research.H22hepatic ascitic cancer cells were directly injected into the left liver lobe of BALB/c nude mice(n=15).EPCs de-

Cognitive function observation and clinical features of 100 cases of elderly patients with non-alcoholic fatty liver disease

Objective To observe the changes of cognitive function,clinical characteristics and hippocampal structure in elderly patients with non-alcoholic fatty liver disease(NAFLD). Methods From December 2014 to June2016,at Department of Geriatrics,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,169 Elderly hospitalized patients whounderwent health check-ups were enrolled and dividedinto NAFLD group and non-NAFLD group. The clinicaldata of two groups were collected,and the Montreal cognitiveassessment scale (MoCA) was used for cognitivefunction assessment. The serum level of soluble transferrinreceptor ( sTfR) was detected,the liver-spleen ratiowas measured and hippocampal proton magnetic resonancespectroscopy (1 H-MRS) was performed.

Association between white matter hyperintensities volume and cognitive function in patients with hypertension

Objective To explore the association between whitematter hyperintensities volume and cognitive function inpatients with hypertension. Methods Eighty-two patientswith hypertension enrolled from the Department of Neurologyof Nanjing Drum Tower Hospital from January2017 to December 2017 were recruited in this study sequentially,who aged between 50 and 80 years. All subjectsused automatic white matter quantitative techniqueto get their personal whole white matter hyperintensities volume,periventricular white matter hyperintensities volumeand deep white matter hyperintensities volume.Neuropsychological scales were used to evaluate theirglobal cognitive function,memory function,fluency,executivefunction and processing speed. The associationbetween white matter hyperintensities volume and cognitivefunction via linear regression analysis was assessed.To explore whether the association between white matterhyperintensities volume and cognitive function be affectedby the duration of hypertension,stratification analyseswere conducted using the median of the duration of hypertensionas separation.

Thyrotropin-secreting adenoma in multiple endocrine neoplasia type 1:one case report and literature review

Objective To improve the understanding of thyrotropin-secreting adenoma in multiple endocrine neoplasia type 1(MEN1)through analyzing the clinical diagnosis and treatment process,as well as outcomes in one case of this disorder.Methods The clinical manifestations,biochemical and hormone levels,imaging presentations,medical and surgical treatments,and post-operational pathologic findings in the process of diagnosis and treatment of a patient with thyrotropin-secreting adenoma in MEN1 were analyzed.

Expert consensus on glycated hemoglobin A1C targets and management algorithm for Chinese adults with type 2 diabetes

Objective The hemoglobin Alc(HbA1C)targets of diabetics should be individualized based on the patientcentered approach,according to numerous factors,such as age,duration of diabetes,comorbid conditions,patient motivation,risk of adverse effects.This consensus recommends a general HbA1C target of<7.0%for most adults with type 2 diabetes mellitus(T2DM).

Efficacy analysis of transjugular intrahe-patic portosystemic shunt in the treatment of esophago-gastric variceal bleeding complicated with cavernous transformation of the portal vein

Objective To explore the safety and efficacy of transjugular intrahepatic portosystemic shunt(TIPS)in the treatment of esophago-gastric variceal bleeding(EGVB)complicated with cavernous transformation of portal vein(CTPV).Methods From January 1,2015 to December 31,2018,the clinical data of liver cirrhosis patients with EGVB and complicated with(CTPV group)or without(non-CTPV group)CTPV receiving TIPS at Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School were retrospectively analyzed.

Prognostic value of modified Charlson morbidity index combined with serum albumin for long-term prognosis in peritoneal dialysis patients

Objective To assess the prognostic value of modified Charlson comorbidity index(mCCI)combined with serum albumin for long-term prognosis in peritoneal dialysis(PD)patients.Methods From January 1,2007 to June 30,2015,patients who started PD in Nanjing Drum Tower Hospital were enrolled in this retrospective cohort study.

Analysis of related factors in intramyocardial hemorrhage after percutaneous coronary intervention for acute ST-segment elevation myocardial infarction

Objective To evaluate the incidence of intramyocardial hemorrhage (IMH) after percutaneous coronary intervention surgery for acute ST-segment elevation myocardial infarction (STEMI) in the Chinese population,and to explore the relevant predictive factors for the IMH formation and provide individualized diagnosis and treatment measures for patients with STEMI.

Application of the Second Revision of the International Staging System(R2-ISS)in the prognostic assessment of newly diagnosed multiple myeloma

Objective To investigate the prognostic value of the Second Revision of the International Staging System (R2-ISS) in patients with newly diagnosed multiple myeloma(NDMM).Methods The retrospective study was performed in 326 NDMM patients with immunomodulatory drugs and/or proteasome inhibitors as the first-line treatment attending the Department of Hematology,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing,China,from December 2012 to March 2022.