BACKGROUND Rhabdomyolysis is a serious complication of heat stroke.Unlike that in acute kidney injury,the risk of muscle bleeding in rhabdomyolysis is often ignored and can substantially increase via the widespread us...BACKGROUND Rhabdomyolysis is a serious complication of heat stroke.Unlike that in acute kidney injury,the risk of muscle bleeding in rhabdomyolysis is often ignored and can substantially increase via the widespread use of anticoagulants,leading to the formation of intramuscular hematoma.CASE SUMMARY During the summer,a middle-aged man and an elderly man were diagnosed with heat stroke,rhabdomyolysis,and acute renal impairment.Low-dose enoxaparin sodium was initiated for prophylaxis of deep vein thrombosis after the disease was stabilized with continuous renal replacement therapy.After that,the patients'hemoglobin decreased progressively,and no obvious intracranial,thoracic,digestive,or skin bleeding tendency was found.However,one of the patients had hip muscle pain,and computed tomography and color ultrasound confirmed that the patients separately had lumbar back and hip intermuscular hematoma.After discontinuation of anticoagulant drugs and monitoring of the steady increase in hemoglobin,the intermuscular hematomas were gradually absorbed.Following the use of prophylactic anticoagulation therapy,the patients'hemoglobin showed a progressive downward trend.Hematoma formation in the lumbosacral and buttock muscles was confirmed after excluding bleeding in typical regions(such as the digestive tract,thoracic cavity,and abdominal cavity).Anticoagulant drugs were discontinued immediately,and nutritional support was increased.Subsequently,the hemoglobin levels gradually increased,and the hematoma volumes gradually decreased.CONCLUSION Patients with rhabdomyolysis have a risk of muscle bleeding,and inappropriate use of anticoagulants may lead to an increased risk or even to the formation of an intermuscular hematoma. When continuous blood loss is found in the body, thepossibility of bleeding in the muscles and more typical sites should be considered.展开更多
AIM: To investigate whether resveratrol (3,4,5-trihydroxy-trans-stilbene) inhibits collagen I synthesis induced by insulin growth factor-1 (IGF-1) in intestinal fibroblasts, and to explore the ...AIM: To investigate whether resveratrol (3,4,5-trihydroxy-trans-stilbene) inhibits collagen I synthesis induced by insulin growth factor-1 (IGF-1) in intestinal fibroblasts, and to explore the possible molecular mechanisms.展开更多
基金Natural Science Foundation of Fujian Province of China,No.2020J011312.
文摘BACKGROUND Rhabdomyolysis is a serious complication of heat stroke.Unlike that in acute kidney injury,the risk of muscle bleeding in rhabdomyolysis is often ignored and can substantially increase via the widespread use of anticoagulants,leading to the formation of intramuscular hematoma.CASE SUMMARY During the summer,a middle-aged man and an elderly man were diagnosed with heat stroke,rhabdomyolysis,and acute renal impairment.Low-dose enoxaparin sodium was initiated for prophylaxis of deep vein thrombosis after the disease was stabilized with continuous renal replacement therapy.After that,the patients'hemoglobin decreased progressively,and no obvious intracranial,thoracic,digestive,or skin bleeding tendency was found.However,one of the patients had hip muscle pain,and computed tomography and color ultrasound confirmed that the patients separately had lumbar back and hip intermuscular hematoma.After discontinuation of anticoagulant drugs and monitoring of the steady increase in hemoglobin,the intermuscular hematomas were gradually absorbed.Following the use of prophylactic anticoagulation therapy,the patients'hemoglobin showed a progressive downward trend.Hematoma formation in the lumbosacral and buttock muscles was confirmed after excluding bleeding in typical regions(such as the digestive tract,thoracic cavity,and abdominal cavity).Anticoagulant drugs were discontinued immediately,and nutritional support was increased.Subsequently,the hemoglobin levels gradually increased,and the hematoma volumes gradually decreased.CONCLUSION Patients with rhabdomyolysis have a risk of muscle bleeding,and inappropriate use of anticoagulants may lead to an increased risk or even to the formation of an intermuscular hematoma. When continuous blood loss is found in the body, thepossibility of bleeding in the muscles and more typical sites should be considered.
基金Supported by the National Natural Science Foundation of China,No.81270462the International Cooperation Project of Jiangsu Province Department of Health,No.SBZ201100103
文摘AIM: To investigate whether resveratrol (3,4,5-trihydroxy-trans-stilbene) inhibits collagen I synthesis induced by insulin growth factor-1 (IGF-1) in intestinal fibroblasts, and to explore the possible molecular mechanisms.
