International patterns and trends of childhood and adolescent cancer, 1978-2012

Background:This study aimed to provide a detailed analysis of the temporal trends of cancer incidence rates for individuals aged 0-19 years in selected regions globally from 1978 to 2012.Methods:Data were obtained from Volumes V-XI of Cancer Incidence in Five Continents(CI5),published by the International Agency for Research on Cancer.A total of 53 registries in 23 regions from the Americas,Asia,Europe,and Oceania that contained information on cancer incidence throughout 1978-2012(35 years)were included in this study.Joinpoint regression was used for the analysis of trends.Results:Most regions showed increasing trends in overall childhood cancer among children(aged 0-14 years)and adolescents(aged 15-19 years).Nearly all regions showed rising trends in childhood and adolescent leukemia incidence rates,whereas the incidence of lymphoma among children generally decreased.Only France,Australia,and New Zealand showed decreasing trends for malignant central nervous system(CNS)tumors among adoles-cents.Kidney cancer and bone cancer incidence rates remained stable for most regions.The incidence of thyroid cancer among adolescents increased in most regions and that of testicular cancer decreased in approximately one-half of the regions studied.Conclusion:The international temporal trends of cancer incidents among children and adolescents are varied by region,cancer type,age group,and gender,and have changed over time.

Characteristics and prognosis of embryonal rhabdomyosarcoma in children and adolescents:An analysis of 464 cases from the SEER database

Importance:As the most common subtype of pediatric rhabdomyosarcoma(RMS),the prognosis of embryonal RMS has rarely been investigated solely.Objective:To perform a population-based study to characterize the prognosis of embryonal RMS in children and adolescents.Methods:Demographic and clinical features were retrospectively evaluated in selected patients with embryonal RMS registered in the Surveillance,Epidemiology,and End Results(SEER)program from 1988 to 2016.Survival curves were compared using the log-rank test.A multivariate Cox proportional hazards model was developed to assess the impact of each factor on the overall survival.A nomogram was constructed based on the results of Cox regression model.Results:A total of 464 patients were included in the analysis,among which 64.6%were male and 70.2%were white patients.About 38.6%and 26.3%of the patients were at 1-4 years and 5-9 years,respectively.Cox analysis showed that patients at age group 5-9 years had the lowest risk of mortality(hazard ratio[HR],0.277;95%confidential interval[CI],0.123-0.620),compared with patients diagnosed at less than 1-year-old,and age group 1-4 years had the second-best prognosis.Patients having distant tumors had significantly higher mortality risk(HR,4.842;95%CI,2.804-8.362)than the patients with localized tumor.Compared with receiving no surgery or radiotherapy,receiving any combination of surgery and radiotherapy would lower the risk of mortality significantly(for surgery without radiotherapy:HR,0.418;for radiotherapy without surgery:HR,0.405;and for surgery plus radiotherapy:HR,0.410).Interpretation:Age,stage at diagnosis,and treatment received were found to be the most important predictors of the overall survival of pediatric embryonal RMS.