Glitches represent a category of non-Gaussian and transient noise that frequently intersects with gravitational wave(GW)signals,thereby exerting a notable impact on the processing of GW data.The inference of GW parame...Glitches represent a category of non-Gaussian and transient noise that frequently intersects with gravitational wave(GW)signals,thereby exerting a notable impact on the processing of GW data.The inference of GW parameters,crucial for GW astronomy research,is particularly susceptible to such interference.In this study,we pioneer the utilization of a temporal and time-spectral fusion normalizing flow for likelihood-free inference of GW parameters,seamlessly integrating the high temporal resolution of the time domain with the frequency separation characteristics of both time and frequency domains.Remarkably,our findings indicate that the accuracy of this inference method is comparable to that of traditional non-glitch sampling techniques.Furthermore,our approach exhibits a greater efficiency,boasting processing times on the order of milliseconds.In conclusion,the application of a normalizing flow emerges as pivotal in handling GW signals affected by transient noises,offering a promising avenue for enhancing the field of GW astronomy research.展开更多
In the coming decades,the space-based gravitational-wave(GW)detectors such as Taiji,TianQin,and LISA are expected to form a network capable of detecting millihertz GWs emitted by the mergers of massive black hole bina...In the coming decades,the space-based gravitational-wave(GW)detectors such as Taiji,TianQin,and LISA are expected to form a network capable of detecting millihertz GWs emitted by the mergers of massive black hole binaries(MBHBs).In this work,we investigate the potential of GW standard sirens from the Taiji-TianQin-LISA network in constraining cosmological parameters.For the optimistic scenario in which electromagnetic(EM)counterparts can be detected,we predict the number of detectable bright sirens based on three different MBHB population models,i.e.,popⅢ,Q3d,and Q3nod.Our results show that the TaijiTianQin-LISA network alone could achieve a constraint precision of 0.9%for the Hubble constant,meeting the standard of precision cosmology.Moreover,the Taiji-TianQin-LISA network could effectively break the cosmological parameter degeneracies generated by the CMB data,particularly in the dynamical dark energy models.When combined with the CMB data,the joint CMB+Taiji-TianQin-LISA data offerσ(w)=0.036 in the wCDM model,which is close to the latest constraint result obtained from the CMB+SN data.We also consider a conservative scenario in which EM counterparts are not available.Due to the precise sky localizations of MBHBs by the Taiji-TianQin-LISA network,the constraint precision of the Hubble constant is expected to reach 1.2%.In conclusion,the GW standard sirens from the Taiji-TianQin-LISA network will play a critical role in helping solve the Hubble tension and shedding light on the nature of dark energy.展开更多
Gravitational waves(GWs) from compact binary coalescences encode the absolute luminosity distances of GW sources. Once the redshifts of GW sources are known, one can use the distance-redshift relation to constrain cos...Gravitational waves(GWs) from compact binary coalescences encode the absolute luminosity distances of GW sources. Once the redshifts of GW sources are known, one can use the distance-redshift relation to constrain cosmological parameters. One way to obtain the redshifts is to localize GW sources by GW observations and then use galaxy catalogs to determine redshifts from a statistical analysis of redshift information of the potential host galaxies, commonly referred to as the dark siren method. The third-generation(3G) GW detectors are planned to work in the 2030s and will observe numerous compact binary coalescences.Using these GW events as dark sirens requires high-quality galaxy catalogs from future sky survey projects. The China Space Station Telescope(CSST) will be launched in 2024 and will observe billions of galaxies within a 17500 deg^(2) survey area with redshift up to z ~ 4, providing photometric and spectroscopic galaxy catalogs. In this work, we simulate the CSST galaxy catalogs and the 5-year GW data from the 3G GW detectors and combine them to infer the Hubble constant(H_(0)). Our results show that the measurement precision of H0could reach the sub-percent level, meeting the standard of precision cosmology. We conclude that the synergy between CSST and the 3G GW detectors is of great significance in measuring the Hubble constant.展开更多
The 21 cm intensity mapping(IM)technique provides us with an efficient way to observe the cosmic large-scale structure(LSS).From the LSS data,one can use the baryon acoustic oscillation and redshift space distortion t...The 21 cm intensity mapping(IM)technique provides us with an efficient way to observe the cosmic large-scale structure(LSS).From the LSS data,one can use the baryon acoustic oscillation and redshift space distortion to trace the expansion and growth history of the universe,and thus measure the dark energy parameters.In this paper,we make a forecast for cosmological parameter estimation with the synergy of three 21 cm IM experiments.Specifically,we adopt a novel joint survey strategy,FAST(0<z<0.35)+SKA1-MID(0.35<z<0.8)+HIRAX(0.8<z<2.5),to measure dark energy.We simulate the 21 cm IM observations under the assumption of excellent foreground removal.We find that the synergy of three experiments could place quite tight constraints on cosmological parameters.For example,it providesσ(?m)=0.0039 andσ(H0)=0.27 km s^(-1) Mpc^(-1) in theΛCDM model.Notably,the synergy could break the cosmological parameter degeneracies when constraining the dynamical dark energy models.Concretely,the joint observation offersσ(w)=0.019 in the wCDM model,andσ(w0)=0.085 andσ(wa)=0.32 in the w0waCDM model.These results are better than or equal to those given by CMB+BAO+SN.In addition,when the foreground removal efficiency is relatively low,the strategy still performs well.Therefore,the 21 cm IM joint survey strategy is promising and worth pursuing.展开更多
Aqueous rechargeable ammonium-ion(NH^(4+))batteries(AAIBs)with ammonium ions as charge carriers possess many advantages,yet the relatively low discharge capacities(e.g.,<200 mAh·g^(−1))of the reported NH_(4)^(...Aqueous rechargeable ammonium-ion(NH^(4+))batteries(AAIBs)with ammonium ions as charge carriers possess many advantages,yet the relatively low discharge capacities(e.g.,<200 mAh·g^(−1))of the reported NH_(4)^(+)host materials hinder the development of AAIBs.Herein,we study the NH_(4)^(+)storage properties of an electrochemically activated NiCo double hydroxide(A-NiCo-DH)in neutral ammonium acetate electrolyte for the first time.The activation process extracts the interlayer anions(NO3from the host material,providing additional cation accommodation sites for charge storage.The introduced H vacancies in A-−)NiCo-DH could activate the O sites,leading to the enhanced cation adsorption capability for the electrode.Therefore,A-NiCo-DH exhibits a high discharge capacity of 280.6 mAh·g^(−1)at 0.72 A·g^(−1)with good rate capability.Spectroscopy studies suggest A-NiCo-DH experiences a NH4+/H+coinsertion mechanism.A NH4+-Zn hybrid cell is assembled using A-NiCo-DH as the cathode and Zn foil as the anode,respectively.The device delivers an energy density of 306 Wh·kg^(−1)at the power density of 745.8 W·kg^(−1)(based on the active mass of A-NiCo-DH).This work provides a new NH_(4)^(+)storage material and would push forward the development of aqueous NH4+-based batteries.展开更多
Gravitational waves(GWs)from compact binary coalescences can be used as standard sirens to explore the cosmic expansion history.In the next decades,it is anticipated that we could obtain the multi-band GW standard sir...Gravitational waves(GWs)from compact binary coalescences can be used as standard sirens to explore the cosmic expansion history.In the next decades,it is anticipated that we could obtain the multi-band GW standard siren data(from nanohertz to a few hundred hertz),which are expected to play an important role in cosmological parameter estimation.In this work,we provide,for the first time to the best of our knowledge,joint constraints on cosmological parameters using the future multi-band GW standard siren observations.We simulate the multi-band GW standard sirens based on the SKA-era pulsar timing array(PTA),Taiji observatory,and Cosmic Explorer(CE)to perform cosmological analysis.In theΛCDM model,we find that the joint PTA+Taiji+CE data could provide a tight constraint on the Hubble constant with a 0.5%precision.Moreover,PTA+Taiji+CE could break the cosmological parameter degeneracies generated by CMB,especially in the dynamical dark energy models.When combining the PTA+Taiji+CE data with the CMB data,the constraint precisions of?_(m)and H_(0)are 1.0%and 0.3%,respectively,meeting the standard of precision cosmology.The joint CMB+PTA+Taiji+CE data giveσ(_(w))=0.028 in the wCDM model andσ(w_(0))=0.11 andσ(w_(a))=0.32 in the w_(0)w_(a)CDM model,which are comparable with or close to the latest constraint results by CMB+BAO+SN.In conclusion,the future multi-band GW observations are expected to be used for exploring the nature of dark energy and measuring the Hubble constant.展开更多
The cosmic curvature Ω_(K,0),which determines the spatial geometry of the universe,is an important parameter in modern cosmology.Any deviation from Ω_(K,0)=0 would have a profound impact on the primordial inflation ...The cosmic curvature Ω_(K,0),which determines the spatial geometry of the universe,is an important parameter in modern cosmology.Any deviation from Ω_(K,0)=0 would have a profound impact on the primordial inflation paradigm and fundamental physics.In this work,we adopt a cosmological model-independent method to test whether Ω_(K,0) deviates from zero.We use the Gaussian process to reconstruct the reduced Hubble parameter E(z)and the derivative of the distance D'(z)from observational data and then determine Ω_(K,0) with a null test relation.The cosmic chronometer(CC)Hubble data,baryon acoustic oscillation(BAO)Hubble data,and supernovae Pantheon sample are considered.Our result is consistent with a spatially flat universe within the domain of reconstruction 0<z<2.3,at the 1σ confidence level.In the redshift interval 0<z<1,the result favors a flat universe,while at z>1,it tends to favor a closed universe.In this sense,there is still a possibility for a closed universe.We also carry out the null test of the cosmic curvature at 0<z<4.5 using the simulated gravitational wave standard sirens,CC+BAO,and redshift drift Hubble data.The result indicates that in the future,with the synergy of multiple highquality observations,we can tightly constrain the spatial geometry or exclude the flat universe.展开更多
Neuroinflammation,mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3(NLRP3)inflammasome,is a significant contributor to the pathogenesis of neurodegenerative disea...Neuroinflammation,mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3(NLRP3)inflammasome,is a significant contributor to the pathogenesis of neurodegenerative diseases(NDDs).Reynos-in,a natural sesquiterpene lactone(SL),exhibits a broad spectrum of pharmacological effects,suggesting its potential therapeutic value.However,the effects and mechanism of reynosin on neuroinflammation remain elusive.The current study explores the effects and mechanisms of reynosin on neuroinflammation using mice and BV-2 microglial cells treated with lipopolysaccharide(LPS).Our findings reveal that reynosin effectively reduces microglial inflammation in vitro,as demonstrated by decreased CD11b expression and lowered interleukin-1 beta(IL-1β)and interleukin-18(IL-18)mRNA and protein levels.Correspondingly,in vivo,results showed a re-duction in the number of Iba-1 positive cells and alleviation of morphological alterations,alongside decreased expressions of IL-1βand IL-18.Further analysis indicates that reynosin inhibits NLRP3 inflammasome activation,evidenced by reduced transcription of NLRP3 and caspase-1,diminished NLRP3 protein expression,inhibited apoptosis-associated speck-like protein containing a CARD(ASC)oli-gomerization,and decreased caspase-1 self-cleavage.Additionally,reynosin curtailed the activation of nicotinamide adenine dinuc-leotide phosphate(NADPH)oxidase,demonstrated by reduced NADP^(+)and NADPH levels,downregulation of gp91^(phox) mRNA,pro-tein expression,suppression of p47^(phox) expression and translocation to the membrane.Moreover,reynosin exhibited a neuroprotective effect against microglial inflammation in vivo and in vitro.These collective findings underscore reynosin’s capacity to mitigate mi-croglial inflammation by inhibiting the NLRP3 inflammasome,thus highlighting its potential as a therapeutic agent for managing neuroinflammation.展开更多
Phenylacetic acid(PAA)is a primary raw material for illegal Methamphetamine(MATM)synthesis under the strong precursor chemicals supervisions of safrole and isosafrole.Therefore,trace detection of PAA at ultra-low conc...Phenylacetic acid(PAA)is a primary raw material for illegal Methamphetamine(MATM)synthesis under the strong precursor chemicals supervisions of safrole and isosafrole.Therefore,trace detection of PAA at ultra-low concentration is a strategic technique and an urgent issue in the field of drug control.In this paper,trace determination of PAA at sub-nmol-L-1 concentration level is achieved by hydrogen bond adsorption and electrochemical catalysis through the prepared aminated SiO_(2)nanoparticles(SiO_(2)-NH_(2) NPs)and MoS_(2) nanosheets(NSs)modified glassy carbon electrode(GCE).The prepared MoS_(2) NS s/SiO_(2)-NH_(2) NPs modified electrode represents a detecting limit of 0.0989 nmol·L^(-1)and an obvious increasing linear range before the concentration increasement up to 60 nmol·L^(-1)in square wave voltammetry(SWV)responses of PAA.The SWV response of the modified electrode to PAA in the concentration range within 100 nmol·L^(-1)is higher than phenol,acetic acid(HOAc)and benzoic Acid(BEN).This electrochemical method for trace detection of PAA in aqueous solution with desired performance provides a feasible scheme for the detection of other drugs and aromatic precursor chemicals.展开更多
We consider a new cosmological model(calledΛCDM),in which the vacuum energy interacts with matter and radiation,and test this model using the current cosmological observations.Using the CMB+BAO+SN(CBS)dataset to cons...We consider a new cosmological model(calledΛCDM),in which the vacuum energy interacts with matter and radiation,and test this model using the current cosmological observations.Using the CMB+BAO+SN(CBS)dataset to constrain the model,we find that H_(0) and S_(8) tensions are relieved to 2.87σand 2.77σ,respectively.However,in this case,theΛCDM model is not favored by the data,compared withΛCDM.We find that when the H_(0) and S_(8) data are added to the data combination,the situation is significantly improved.In the CBS+H_(0) case,the model relieves the H_(0) tension to 0.47σ,and the model is favored overΛCDM.In the CBS+H_(0)+S_(8) case,we obtain a synthetically best situation,in which the H_(0) and S_(8) tensions are relieved to 0.72σand 2.11σ,respectively.In this case,the model is most favored by the data.Therefore,this cosmological model can greatly relieve the H_(0) tension and simultaneously effectively alleviate the S_(8) tension.展开更多
基金the National SKA Program of China(2022SKA0110200,2022SKA0110203)the National Natural Science Foundation of China(11975072,11875102,11835009)the National 111 Project(B16009)。
文摘Glitches represent a category of non-Gaussian and transient noise that frequently intersects with gravitational wave(GW)signals,thereby exerting a notable impact on the processing of GW data.The inference of GW parameters,crucial for GW astronomy research,is particularly susceptible to such interference.In this study,we pioneer the utilization of a temporal and time-spectral fusion normalizing flow for likelihood-free inference of GW parameters,seamlessly integrating the high temporal resolution of the time domain with the frequency separation characteristics of both time and frequency domains.Remarkably,our findings indicate that the accuracy of this inference method is comparable to that of traditional non-glitch sampling techniques.Furthermore,our approach exhibits a greater efficiency,boasting processing times on the order of milliseconds.In conclusion,the application of a normalizing flow emerges as pivotal in handling GW signals affected by transient noises,offering a promising avenue for enhancing the field of GW astronomy research.
基金supported by the National SKA Program of China(Grant Nos.2022SKA0110200,and 2022SKA0110203)the National Natural Science Foundation of China(Grant Nos.11975072,11875102,and 11835009)+1 种基金the National 111 Project(Grant No.B16009)the Fundamental Research Funds for the Central Universities(Grant No.N232410019)。
文摘In the coming decades,the space-based gravitational-wave(GW)detectors such as Taiji,TianQin,and LISA are expected to form a network capable of detecting millihertz GWs emitted by the mergers of massive black hole binaries(MBHBs).In this work,we investigate the potential of GW standard sirens from the Taiji-TianQin-LISA network in constraining cosmological parameters.For the optimistic scenario in which electromagnetic(EM)counterparts can be detected,we predict the number of detectable bright sirens based on three different MBHB population models,i.e.,popⅢ,Q3d,and Q3nod.Our results show that the TaijiTianQin-LISA network alone could achieve a constraint precision of 0.9%for the Hubble constant,meeting the standard of precision cosmology.Moreover,the Taiji-TianQin-LISA network could effectively break the cosmological parameter degeneracies generated by the CMB data,particularly in the dynamical dark energy models.When combined with the CMB data,the joint CMB+Taiji-TianQin-LISA data offerσ(w)=0.036 in the wCDM model,which is close to the latest constraint result obtained from the CMB+SN data.We also consider a conservative scenario in which EM counterparts are not available.Due to the precise sky localizations of MBHBs by the Taiji-TianQin-LISA network,the constraint precision of the Hubble constant is expected to reach 1.2%.In conclusion,the GW standard sirens from the Taiji-TianQin-LISA network will play a critical role in helping solve the Hubble tension and shedding light on the nature of dark energy.
基金supported by the National SKA Program of China (Grant Nos.2022SKA0110200, and 2022SKA0110203)the National Natural Science Foundation of China (Grant Nos. 11975072, 11875102, and 11835009)+1 种基金the science research grants from the China Manned Space Project (Grant No. CMS-CSST-2021-B01)the 111 Project (Grant No. B16009)。
文摘Gravitational waves(GWs) from compact binary coalescences encode the absolute luminosity distances of GW sources. Once the redshifts of GW sources are known, one can use the distance-redshift relation to constrain cosmological parameters. One way to obtain the redshifts is to localize GW sources by GW observations and then use galaxy catalogs to determine redshifts from a statistical analysis of redshift information of the potential host galaxies, commonly referred to as the dark siren method. The third-generation(3G) GW detectors are planned to work in the 2030s and will observe numerous compact binary coalescences.Using these GW events as dark sirens requires high-quality galaxy catalogs from future sky survey projects. The China Space Station Telescope(CSST) will be launched in 2024 and will observe billions of galaxies within a 17500 deg^(2) survey area with redshift up to z ~ 4, providing photometric and spectroscopic galaxy catalogs. In this work, we simulate the CSST galaxy catalogs and the 5-year GW data from the 3G GW detectors and combine them to infer the Hubble constant(H_(0)). Our results show that the measurement precision of H0could reach the sub-percent level, meeting the standard of precision cosmology. We conclude that the synergy between CSST and the 3G GW detectors is of great significance in measuring the Hubble constant.
基金supported by the National SKA Program of China(Grant Nos.2022SKA0110200,and 2022SKA0110203)National Natural Science Foundation of China(Grant Nos.11975072,11835009,and 11875102)。
文摘The 21 cm intensity mapping(IM)technique provides us with an efficient way to observe the cosmic large-scale structure(LSS).From the LSS data,one can use the baryon acoustic oscillation and redshift space distortion to trace the expansion and growth history of the universe,and thus measure the dark energy parameters.In this paper,we make a forecast for cosmological parameter estimation with the synergy of three 21 cm IM experiments.Specifically,we adopt a novel joint survey strategy,FAST(0<z<0.35)+SKA1-MID(0.35<z<0.8)+HIRAX(0.8<z<2.5),to measure dark energy.We simulate the 21 cm IM observations under the assumption of excellent foreground removal.We find that the synergy of three experiments could place quite tight constraints on cosmological parameters.For example,it providesσ(?m)=0.0039 andσ(H0)=0.27 km s^(-1) Mpc^(-1) in theΛCDM model.Notably,the synergy could break the cosmological parameter degeneracies when constraining the dynamical dark energy models.Concretely,the joint observation offersσ(w)=0.019 in the wCDM model,andσ(w0)=0.085 andσ(wa)=0.32 in the w0waCDM model.These results are better than or equal to those given by CMB+BAO+SN.In addition,when the foreground removal efficiency is relatively low,the strategy still performs well.Therefore,the 21 cm IM joint survey strategy is promising and worth pursuing.
基金the National Natural Science Foundation of China(No.51804066)the Fundamental Research Funds for the Central Universities(No.N2205003)+1 种基金X.X.L.acknowledges the support by the 111 Project(B16009)the financial support from LiaoNing Science and Technology Development Foundation Guided by Central Government(No.2021JH6/10500139).
文摘Aqueous rechargeable ammonium-ion(NH^(4+))batteries(AAIBs)with ammonium ions as charge carriers possess many advantages,yet the relatively low discharge capacities(e.g.,<200 mAh·g^(−1))of the reported NH_(4)^(+)host materials hinder the development of AAIBs.Herein,we study the NH_(4)^(+)storage properties of an electrochemically activated NiCo double hydroxide(A-NiCo-DH)in neutral ammonium acetate electrolyte for the first time.The activation process extracts the interlayer anions(NO3from the host material,providing additional cation accommodation sites for charge storage.The introduced H vacancies in A-−)NiCo-DH could activate the O sites,leading to the enhanced cation adsorption capability for the electrode.Therefore,A-NiCo-DH exhibits a high discharge capacity of 280.6 mAh·g^(−1)at 0.72 A·g^(−1)with good rate capability.Spectroscopy studies suggest A-NiCo-DH experiences a NH4+/H+coinsertion mechanism.A NH4+-Zn hybrid cell is assembled using A-NiCo-DH as the cathode and Zn foil as the anode,respectively.The device delivers an energy density of 306 Wh·kg^(−1)at the power density of 745.8 W·kg^(−1)(based on the active mass of A-NiCo-DH).This work provides a new NH_(4)^(+)storage material and would push forward the development of aqueous NH4+-based batteries.
基金Supported by the National SKA Program of China(2022SKA0110200,2022SKA0110203)the National Natural Science Foundation of China(11975072,11875102,11835009)。
文摘Gravitational waves(GWs)from compact binary coalescences can be used as standard sirens to explore the cosmic expansion history.In the next decades,it is anticipated that we could obtain the multi-band GW standard siren data(from nanohertz to a few hundred hertz),which are expected to play an important role in cosmological parameter estimation.In this work,we provide,for the first time to the best of our knowledge,joint constraints on cosmological parameters using the future multi-band GW standard siren observations.We simulate the multi-band GW standard sirens based on the SKA-era pulsar timing array(PTA),Taiji observatory,and Cosmic Explorer(CE)to perform cosmological analysis.In theΛCDM model,we find that the joint PTA+Taiji+CE data could provide a tight constraint on the Hubble constant with a 0.5%precision.Moreover,PTA+Taiji+CE could break the cosmological parameter degeneracies generated by CMB,especially in the dynamical dark energy models.When combining the PTA+Taiji+CE data with the CMB data,the constraint precisions of?_(m)and H_(0)are 1.0%and 0.3%,respectively,meeting the standard of precision cosmology.The joint CMB+PTA+Taiji+CE data giveσ(_(w))=0.028 in the wCDM model andσ(w_(0))=0.11 andσ(w_(a))=0.32 in the w_(0)w_(a)CDM model,which are comparable with or close to the latest constraint results by CMB+BAO+SN.In conclusion,the future multi-band GW observations are expected to be used for exploring the nature of dark energy and measuring the Hubble constant.
基金Supported by the National SKA Program of China(2022SKA0110200,2022SKA0110203)the National Natural Science Foundation of China(11975072,11835009,11875102)。
文摘The cosmic curvature Ω_(K,0),which determines the spatial geometry of the universe,is an important parameter in modern cosmology.Any deviation from Ω_(K,0)=0 would have a profound impact on the primordial inflation paradigm and fundamental physics.In this work,we adopt a cosmological model-independent method to test whether Ω_(K,0) deviates from zero.We use the Gaussian process to reconstruct the reduced Hubble parameter E(z)and the derivative of the distance D'(z)from observational data and then determine Ω_(K,0) with a null test relation.The cosmic chronometer(CC)Hubble data,baryon acoustic oscillation(BAO)Hubble data,and supernovae Pantheon sample are considered.Our result is consistent with a spatially flat universe within the domain of reconstruction 0<z<2.3,at the 1σ confidence level.In the redshift interval 0<z<1,the result favors a flat universe,while at z>1,it tends to favor a closed universe.In this sense,there is still a possibility for a closed universe.We also carry out the null test of the cosmic curvature at 0<z<4.5 using the simulated gravitational wave standard sirens,CC+BAO,and redshift drift Hubble data.The result indicates that in the future,with the synergy of multiple highquality observations,we can tightly constrain the spatial geometry or exclude the flat universe.
基金supported by the National Natural Science Foundation of China(No.82174076)the Construction Project of Liaoning Provincial Key Laboratory,China(No.2022JH13/10200026)+2 种基金the Fundamental Research Funds for the Central Universities(No.N2220002),the 111 Project(No.B16009)Scientific Research Fund of Liaoning Province Education Department(No.LJKZ0945)Natural Science Foundation of Liaoning Province(No.2022-MS-242).
文摘Neuroinflammation,mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3(NLRP3)inflammasome,is a significant contributor to the pathogenesis of neurodegenerative diseases(NDDs).Reynos-in,a natural sesquiterpene lactone(SL),exhibits a broad spectrum of pharmacological effects,suggesting its potential therapeutic value.However,the effects and mechanism of reynosin on neuroinflammation remain elusive.The current study explores the effects and mechanisms of reynosin on neuroinflammation using mice and BV-2 microglial cells treated with lipopolysaccharide(LPS).Our findings reveal that reynosin effectively reduces microglial inflammation in vitro,as demonstrated by decreased CD11b expression and lowered interleukin-1 beta(IL-1β)and interleukin-18(IL-18)mRNA and protein levels.Correspondingly,in vivo,results showed a re-duction in the number of Iba-1 positive cells and alleviation of morphological alterations,alongside decreased expressions of IL-1βand IL-18.Further analysis indicates that reynosin inhibits NLRP3 inflammasome activation,evidenced by reduced transcription of NLRP3 and caspase-1,diminished NLRP3 protein expression,inhibited apoptosis-associated speck-like protein containing a CARD(ASC)oli-gomerization,and decreased caspase-1 self-cleavage.Additionally,reynosin curtailed the activation of nicotinamide adenine dinuc-leotide phosphate(NADPH)oxidase,demonstrated by reduced NADP^(+)and NADPH levels,downregulation of gp91^(phox) mRNA,pro-tein expression,suppression of p47^(phox) expression and translocation to the membrane.Moreover,reynosin exhibited a neuroprotective effect against microglial inflammation in vivo and in vitro.These collective findings underscore reynosin’s capacity to mitigate mi-croglial inflammation by inhibiting the NLRP3 inflammasome,thus highlighting its potential as a therapeutic agent for managing neuroinflammation.
基金financially supported by the National Natural Science Foundation of China (Nos.62033002,62071112 and 61973058)the Program of the Ministry of Education of China for Introducing Talents of Discipline to Universities (No.B16009)+1 种基金the Fundamental Research Funds for the Central Universities in China (No.N2201008)Hebei Natural Science Foundation (No.F2020501040)。
文摘Phenylacetic acid(PAA)is a primary raw material for illegal Methamphetamine(MATM)synthesis under the strong precursor chemicals supervisions of safrole and isosafrole.Therefore,trace detection of PAA at ultra-low concentration is a strategic technique and an urgent issue in the field of drug control.In this paper,trace determination of PAA at sub-nmol-L-1 concentration level is achieved by hydrogen bond adsorption and electrochemical catalysis through the prepared aminated SiO_(2)nanoparticles(SiO_(2)-NH_(2) NPs)and MoS_(2) nanosheets(NSs)modified glassy carbon electrode(GCE).The prepared MoS_(2) NS s/SiO_(2)-NH_(2) NPs modified electrode represents a detecting limit of 0.0989 nmol·L^(-1)and an obvious increasing linear range before the concentration increasement up to 60 nmol·L^(-1)in square wave voltammetry(SWV)responses of PAA.The SWV response of the modified electrode to PAA in the concentration range within 100 nmol·L^(-1)is higher than phenol,acetic acid(HOAc)and benzoic Acid(BEN).This electrochemical method for trace detection of PAA in aqueous solution with desired performance provides a feasible scheme for the detection of other drugs and aromatic precursor chemicals.
基金Supported by the National SKA Program of China(2022SKA0110200,2022SKA0110203)the National Natural Science Foundation of China(11975072,11875102,11835009)。
文摘We consider a new cosmological model(calledΛCDM),in which the vacuum energy interacts with matter and radiation,and test this model using the current cosmological observations.Using the CMB+BAO+SN(CBS)dataset to constrain the model,we find that H_(0) and S_(8) tensions are relieved to 2.87σand 2.77σ,respectively.However,in this case,theΛCDM model is not favored by the data,compared withΛCDM.We find that when the H_(0) and S_(8) data are added to the data combination,the situation is significantly improved.In the CBS+H_(0) case,the model relieves the H_(0) tension to 0.47σ,and the model is favored overΛCDM.In the CBS+H_(0)+S_(8) case,we obtain a synthetically best situation,in which the H_(0) and S_(8) tensions are relieved to 0.72σand 2.11σ,respectively.In this case,the model is most favored by the data.Therefore,this cosmological model can greatly relieve the H_(0) tension and simultaneously effectively alleviate the S_(8) tension.