It is generally believed that there is no dose-rate sparing effect for mammalian cells exposed to high-LET heavy ion beams. To clarify this ambiguity, human salivary gland (HSG) cells were irradiated with carbon ion b...It is generally believed that there is no dose-rate sparing effect for mammalian cells exposed to high-LET heavy ion beams. To clarify this ambiguity, human salivary gland (HSG) cells were irradiated with carbon ion beams supplied by the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan at a low dose rate of 0.展开更多
A β-delayed particle decay 9C-ion beam as a type of double irradiation source is expected to enhance the curative effect when applying it to heavy-ion cancer therapy. It has been proved in our previous
An enhanced cell-killing effect at the penetration depths around the Bragg peak of a β-delayed particle decay 9C -ion beam has been observed in our preceding radiobiological experiments in comparison with a therapeut...An enhanced cell-killing effect at the penetration depths around the Bragg peak of a β-delayed particle decay 9C -ion beam has been observed in our preceding radiobiological experiments in comparison with a therapeutic 12C beam under the same conditions, and RBE values of the 9C beam were revealed to be higher than those of the comparative 12C beam by a factor of up to 2. This study was aimed at investigating the biophysical mechanisms underlying the important experimental phenomenon.展开更多
A β-delayed particle decay beam like 9C has been recognized as a double irradiation source, i.e. the external beam radiation itself and the delayed low-energy particles emitted internally. A radioactive 9C-ion beam, ...A β-delayed particle decay beam like 9C has been recognized as a double irradiation source, i.e. the external beam radiation itself and the delayed low-energy particles emitted internally. A radioactive 9C-ion beam, therefore, is considered to be very useful in cancer radiation therapy. To explore the potential importance of radioactive 9C-ion beams in cancer therapy, radiobiological experiments using a 9C beam supplied by the secondary beam line (SBL) at the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan were carried out.展开更多
文摘It is generally believed that there is no dose-rate sparing effect for mammalian cells exposed to high-LET heavy ion beams. To clarify this ambiguity, human salivary gland (HSG) cells were irradiated with carbon ion beams supplied by the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan at a low dose rate of 0.
文摘A β-delayed particle decay 9C-ion beam as a type of double irradiation source is expected to enhance the curative effect when applying it to heavy-ion cancer therapy. It has been proved in our previous
文摘An enhanced cell-killing effect at the penetration depths around the Bragg peak of a β-delayed particle decay 9C -ion beam has been observed in our preceding radiobiological experiments in comparison with a therapeutic 12C beam under the same conditions, and RBE values of the 9C beam were revealed to be higher than those of the comparative 12C beam by a factor of up to 2. This study was aimed at investigating the biophysical mechanisms underlying the important experimental phenomenon.
文摘A β-delayed particle decay beam like 9C has been recognized as a double irradiation source, i.e. the external beam radiation itself and the delayed low-energy particles emitted internally. A radioactive 9C-ion beam, therefore, is considered to be very useful in cancer radiation therapy. To explore the potential importance of radioactive 9C-ion beams in cancer therapy, radiobiological experiments using a 9C beam supplied by the secondary beam line (SBL) at the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan were carried out.
