<strong>Background</strong>: Many literature reviews report vitamin E supplementation as a benefit chemopreventive and adjuvant therapy in breast and prostate cancers. We investigated in the present work, ...<strong>Background</strong>: Many literature reviews report vitamin E supplementation as a benefit chemopreventive and adjuvant therapy in breast and prostate cancers. We investigated in the present work, alpha-tocopherol (<span style="white-space:nowrap;">α</span>-T) expression (the current active form of vitamin E) from tissues of Congolese patients neither smokers nor alcohol drinkers and without intake antioxidant vitamins supplement. <strong>Methods</strong>: <span style="white-space:nowrap;">α</span>-T was analysed in one normal placenta of nine weeks of gestation and in nineteen cancerous tissues, including seven breast cancers, six prostate cancers, and six gestational choriocarcinomas. The study was performed by immunohistochemistry method after diagnosis confirmation by histological analysis. <strong>Results</strong>: <span style="white-space:nowrap;">α</span>-T staining in membrane cells and collagen fibers presented a moderate expression in healthy sections of tissues (positive control), but the labelling was strong in breast, prostate adenocarcinomas, and in choriocarcinomas. <strong>Conclusion</strong>: Tumors immunohistochemistry of <span style="white-space:nowrap;">α</span>-tocopherol in breast, prostate cancers and in choriocarcinoma show elevated immunostaining suggesting a probable oncogenic effect of the micronutrient.展开更多
We conducted a study to evaluate the sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) of five serologic tests. Subjects with negative or positive COVID-19 polyme...We conducted a study to evaluate the sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) of five serologic tests. Subjects with negative or positive COVID-19 polymerase chain reaction (PRC) test results were tested with each of the serological tests. The results were compared with the reference PCR test. For the five tests evaluated, the Se ranged from 55.0% to 70.0% and the Sp ranged from 67.2% to 86.2%. PPV ranged from 53.2% to 80% and NPV from 75.0% to 86.2%. One test, the Wantai, had better specificity and sensitivity. None of the five tests had performance values of more than 90% in the entire sample. In symptomatic positive cases, the Wantai test reported excellent sensitivity. Overall, the low level of diagnostic performance of these tests does not support their use as an alternative to PCR for COVID-19 diagnostic. Test with better performance can be used for mass screening in low prevalence populations, to limit the indiscriminate use of PCR in context of resource-limited countries. Given the excellent sensitivity of Wantai in symptomatic cases, this test could be used as a referral test only in health facilities to discriminate suspected cases before PCR confirmation.展开更多
文摘<strong>Background</strong>: Many literature reviews report vitamin E supplementation as a benefit chemopreventive and adjuvant therapy in breast and prostate cancers. We investigated in the present work, alpha-tocopherol (<span style="white-space:nowrap;">α</span>-T) expression (the current active form of vitamin E) from tissues of Congolese patients neither smokers nor alcohol drinkers and without intake antioxidant vitamins supplement. <strong>Methods</strong>: <span style="white-space:nowrap;">α</span>-T was analysed in one normal placenta of nine weeks of gestation and in nineteen cancerous tissues, including seven breast cancers, six prostate cancers, and six gestational choriocarcinomas. The study was performed by immunohistochemistry method after diagnosis confirmation by histological analysis. <strong>Results</strong>: <span style="white-space:nowrap;">α</span>-T staining in membrane cells and collagen fibers presented a moderate expression in healthy sections of tissues (positive control), but the labelling was strong in breast, prostate adenocarcinomas, and in choriocarcinomas. <strong>Conclusion</strong>: Tumors immunohistochemistry of <span style="white-space:nowrap;">α</span>-tocopherol in breast, prostate cancers and in choriocarcinoma show elevated immunostaining suggesting a probable oncogenic effect of the micronutrient.
文摘We conducted a study to evaluate the sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) of five serologic tests. Subjects with negative or positive COVID-19 polymerase chain reaction (PRC) test results were tested with each of the serological tests. The results were compared with the reference PCR test. For the five tests evaluated, the Se ranged from 55.0% to 70.0% and the Sp ranged from 67.2% to 86.2%. PPV ranged from 53.2% to 80% and NPV from 75.0% to 86.2%. One test, the Wantai, had better specificity and sensitivity. None of the five tests had performance values of more than 90% in the entire sample. In symptomatic positive cases, the Wantai test reported excellent sensitivity. Overall, the low level of diagnostic performance of these tests does not support their use as an alternative to PCR for COVID-19 diagnostic. Test with better performance can be used for mass screening in low prevalence populations, to limit the indiscriminate use of PCR in context of resource-limited countries. Given the excellent sensitivity of Wantai in symptomatic cases, this test could be used as a referral test only in health facilities to discriminate suspected cases before PCR confirmation.
