Heart rhythm disturbances become of special importancewhen patients reach a senior age. Atrial fibrillation （AF） isthe most prevalent arrhythmia among the old age groups,and its impact on morbidity and mortality bec...Heart rhythm disturbances become of special importancewhen patients reach a senior age. Atrial fibrillation （AF） isthe most prevalent arrhythmia among the old age groups,and its impact on morbidity and mortality becomes of para-mount significance. In this population, AF is responsible forsignificant amount of thromboembolic cerebrovascularevents, especially for disabling and fatal strokes, Follow-ing announcement of the special issue of the Journal of Geri-atric Cardiology devoted to heart rhythm disorders in theelderly, a number of submissions have been received withAF as the major topic of authors＇ researches.展开更多
Objective To examine the prevalence of atrial fibrillation(AF),its impacts on cardiovascular disease(CVD)and all-cause mortality,and the associations between AF and inflammatory and serum biomarkers in a population-ba...Objective To examine the prevalence of atrial fibrillation(AF),its impacts on cardiovascular disease(CVD)and all-cause mortality,and the associations between AF and inflammatory and serum biomarkers in a population-based sample of Muscovites.Methods The study is a secondary analysis of data from the Stress,Aging and Health in Russia(SAHR)survey that includes information on 1800 individuals with an average age of 68.5 years at baseline,and on their subsequent mortality during 7.4 years on average.AF is detected by 12-lead electrocardiogram(ECG)and 24-hour Holter monitoring.The statistical analysis includes proportional hazard and logistic regression models.Results Of the 1732 participants with relevant Holter data,AF was detected in 100(74 by ECG and Holter,26 by Holter only).The prevalence of AF was 5.8%for men and 7.4%for women.The fully adjusted model showed strongly elevated hazard of CVD and all-cause mortality in men and women with long non-self-limiting AF(LAF).LAF was found to be negatively associated with elevated total and lowdensity lipoprotein cholesterol and to be positively associated with elevated markers of inflammation in women.Conclusions The study assessed for the first time the prevalence and the risks of death related to AF among older Russians.LAF was shown to be a strong and independent predictor of CVD and all-cause mortality.AF is unlikely to contribute to the large excess male mortality in Russia.The finding that one-quarter of AF cases were detected only by Holter monitoring demonstrates the usefulness of diagnostics with prolonged ECG registration.展开更多
Two emerging noninvasive neurostimulation technologies, based on electrocutaneius stimulation of the tongue (CN-NINM) and the neck (SYMPATOCORRECTION) are presented. Currently, two portable devices were developed and ...Two emerging noninvasive neurostimulation technologies, based on electrocutaneius stimulation of the tongue (CN-NINM) and the neck (SYMPATOCORRECTION) are presented. Currently, two portable devices were developed and introduced in clinical practice: PoNSTM (portable neurostimulator) and SYMPATOCOR. Both technologies are complement each other and demonstrate perspectives in various applications for purpose of neurorehabilitation and neurological symptoms management in such difficult rehabilitation areas, as traumatic brain injury, stroke, Parkinson’s disease, multiple sclerosis and many other neurological disorders.展开更多
The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers ...The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry.展开更多
文摘Heart rhythm disturbances become of special importancewhen patients reach a senior age. Atrial fibrillation （AF） isthe most prevalent arrhythmia among the old age groups,and its impact on morbidity and mortality becomes of para-mount significance. In this population, AF is responsible forsignificant amount of thromboembolic cerebrovascularevents, especially for disabling and fatal strokes, Follow-ing announcement of the special issue of the Journal of Geri-atric Cardiology devoted to heart rhythm disorders in theelderly, a number of submissions have been received withAF as the major topic of authors＇ researches.
基金supported by the U.S. National Institutes of Health(NIH) grant P01AG031719supported by the Russian program of the state support of leading universities of the Russian Federation “5-100”supported by the Russian Federation President Grant Council’s grant #MD-2314.2020.7
文摘Objective To examine the prevalence of atrial fibrillation(AF),its impacts on cardiovascular disease(CVD)and all-cause mortality,and the associations between AF and inflammatory and serum biomarkers in a population-based sample of Muscovites.Methods The study is a secondary analysis of data from the Stress,Aging and Health in Russia(SAHR)survey that includes information on 1800 individuals with an average age of 68.5 years at baseline,and on their subsequent mortality during 7.4 years on average.AF is detected by 12-lead electrocardiogram(ECG)and 24-hour Holter monitoring.The statistical analysis includes proportional hazard and logistic regression models.Results Of the 1732 participants with relevant Holter data,AF was detected in 100(74 by ECG and Holter,26 by Holter only).The prevalence of AF was 5.8%for men and 7.4%for women.The fully adjusted model showed strongly elevated hazard of CVD and all-cause mortality in men and women with long non-self-limiting AF(LAF).LAF was found to be negatively associated with elevated total and lowdensity lipoprotein cholesterol and to be positively associated with elevated markers of inflammation in women.Conclusions The study assessed for the first time the prevalence and the risks of death related to AF among older Russians.LAF was shown to be a strong and independent predictor of CVD and all-cause mortality.AF is unlikely to contribute to the large excess male mortality in Russia.The finding that one-quarter of AF cases were detected only by Holter monitoring demonstrates the usefulness of diagnostics with prolonged ECG registration.
文摘Two emerging noninvasive neurostimulation technologies, based on electrocutaneius stimulation of the tongue (CN-NINM) and the neck (SYMPATOCORRECTION) are presented. Currently, two portable devices were developed and introduced in clinical practice: PoNSTM (portable neurostimulator) and SYMPATOCOR. Both technologies are complement each other and demonstrate perspectives in various applications for purpose of neurorehabilitation and neurological symptoms management in such difficult rehabilitation areas, as traumatic brain injury, stroke, Parkinson’s disease, multiple sclerosis and many other neurological disorders.
文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry.
