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A Case of Pelvic Migraine
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作者 Conor O’Brien 《Open Journal of Obstetrics and Gynecology》 2015年第11期672-675,共4页
A 62-year-old woman presented with an 8-year history of chronic persisting pelvic pain. She described constant throbbing, stabbing vaginal pain. A pelvic floor neurophysiological assessment of the pudendal nerve was p... A 62-year-old woman presented with an 8-year history of chronic persisting pelvic pain. She described constant throbbing, stabbing vaginal pain. A pelvic floor neurophysiological assessment of the pudendal nerve was performed by performing a needle EMG to the left and right external anal sphincter assessing for insertional activity and recruitment pattern. A quantitative assessment of the motor unit action potentials [MUAPs] was also performed. Tests confirmed a left pudendal neuropathy with chronic denervation in the left external anal sphincter, with reasonable muscle function, with a recruitment pattern of 65% - 70% of normal. The CAR showed an elevated sensory threshold with a normal distal latency. All other conventional pudendal nerve treatments including oral antiepileptic medication, neuromodulation and pudendal nerve blocking injections had failed, and the patient was exacerbated by the persisting pain and discomfort. In this case, 30 international units (iu) of botulinum toxin type A in 10 divided doses of 3 iu were injected along the nerve. Four days later the patient reported a significant improvement in the pain symptoms. She was reviewed 3 weeks later and for the first time in 8 years had made the 70 mile journey to the clinic as a passenger in her husband’s car. This case highlights a new therapeutic option of botulinum toxin type A injection, along the nerve length, for this common painful condition. It seems to have clinical veracity as unlike other therapeutic option the affect lasts for 3 or 4 months. 展开更多
关键词 Pudendal NEUROPATHY VAGINAL Birth PELVIC Pain MIGRAINE PELVIC MIGRAINE BOTULINUM Toxin Injection PELVIC Floor NEUROPHYSIOLOGY
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苯巴比妥和卡马西平应用于儿童期癫痫的副作用:随机对照研究 被引量:1
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作者 Selina H Banu Moshrat Jahan +4 位作者 Umme Kulsum Koli Saadia Ferdousi Naila Z Khan Brian Neville 魏研萍 《英国医学杂志中文版》 2007年第5期272-275,共4页
目的比较两种最常用的抗癫痫药物——苯巴比妥和卡马西平在孟加拉儿童癫痫患者中应用时的行为学副作用。设计前瞻性随机对照单中心研究。地点孟加拉 Dhaka 儿童专科医院。对象 108例2~15岁全身性强直-阵挛发作(51例)或局限性继发全身... 目的比较两种最常用的抗癫痫药物——苯巴比妥和卡马西平在孟加拉儿童癫痫患者中应用时的行为学副作用。设计前瞻性随机对照单中心研究。地点孟加拉 Dhaka 儿童专科医院。对象 108例2~15岁全身性强直-阵挛发作(51例)或局限性继发全身性发作(57例)的患儿。主要结局评估指标癫痫控制和行为学副作用。结果 91例患儿随访12个月。6例需改用其他抗癫痫药物。比较了85例患儿的药物副作用。药物治疗和随访1年,在随访中的后1/4时间,71例患儿未再癫痫发作。随机分组后,苯巴比妥组32例102天、卡马西平组39例74天未再癫痫发作。10例患儿行为学问题增多,其中4例不能接受(苯巴比妥组1例,卡马西平组3例)。但独立 t 检验显示,两组试验药物间没有显著性差异。结论在资源缺乏的国家,苯巴比妥不引起癫痫儿童过多的行为学副作用。临床试验注册号 NCT00381537[ClinicalTrials.gov]。 展开更多
关键词 药物副作用 随机对照研究 儿童期癫痫 苯巴比妥 卡马西平 强直一阵挛发作 抗癫痫药物 全身性发作
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Functional MRI of the human brain following auricular stimulation
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作者 D.Alimi A.Geissmann D.Gardeur 《World Journal of Acupuncture-Moxibustion》 2009年第2期64-64,共1页
Background:Acupuncture studies have used neuroradiology procedures to examine the role of the central nervous system (CNS) in body acupuncture, but none of these previous studies investigated CNS relationships to auri... Background:Acupuncture studies have used neuroradiology procedures to examine the role of the central nervous system (CNS) in body acupuncture, but none of these previous studies investigated CNS relationships to auriculotherapy. 展开更多
关键词 中医治疗学 MRI 针灸 CNS 临床
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