Manipulating emergent quantum phenomena is a key issue for understanding the underlying physics and contributing to possible applications.Here we study the evolution of insulating ground states of Ta_(2)Pu_(3)Te_(5) a...Manipulating emergent quantum phenomena is a key issue for understanding the underlying physics and contributing to possible applications.Here we study the evolution of insulating ground states of Ta_(2)Pu_(3)Te_(5) and Ta_(2)Ni_(3)Te_(5) under in-situ surface potassium deposition via angle-resolved photoemission spectroscopy.Our results confirm the excitonic insulator character of Ta_(2)d_(3)Te_(5).Upon surface doping,the size of its global gap decreases obviously.After a deposition time of more than 7 min,the potassium atoms induce a metal-insulator phase transition and make the system recover to a normal state.In contrast,our results show that the isostructural compound Ta_(2)Ni_(3)Te_(5) is a conventional insulator.The size of its global gap decreases upon surface doping,but persists positive throughout the doping process.Our results not only confirm the excitonic origin of the band gap in Ta_(2)Pd_(3)Te_(5),but also offer an effective method for designing functional quantum devices in the future.展开更多
Recently,high temperature(T_(c)≈80 K)superconductivity(SC)has been discovered in La_(3)Ni_(2)O_(7)(LNO)under pressure.This raises the question of whether the superconducting transition temperature T_(c) could be furt...Recently,high temperature(T_(c)≈80 K)superconductivity(SC)has been discovered in La_(3)Ni_(2)O_(7)(LNO)under pressure.This raises the question of whether the superconducting transition temperature T_(c) could be further enhanced under suitable conditions.One possible route for achieving higher T_(c) is element substitution.Similar SC could appear in the Fmmm phase of rare-earth(RE)R_(3)Ni_(2)O_(7)(RNO,R=RE element)material series under suitable pressure.The electronic properties in the RNO materials are dominated by the Ni 3d orbitals in the bilayer NiO_(2) plane.In the strong coupling limit,the SC could be fully characterized by a bilayer single 3d_(x^(2)−y^(2))-orbital t–J‖–J⊥ model.With RE element substitution from La to other RE element,the lattice constant of the Fmmm RNO material decreases,and the resultant electronic hopping integral increases,leading to stronger superexchanges between the 3d_(x^(2)−y^(2)) orbitals.Based on the slave-boson mean-field theory,we explore the pairing nature and the evolution of T_(c) in RNO materials under pressure.Consequently,it is found that the element substitution does not alter the pairing nature,i.e.,the inter-layer s-wave pairing is always favored in the superconducting RNO under pressure.However,the T_(c) increases from La to Sm,and a nearly doubled T_(c) could be realized in SmNO under pressure.This work provides evidence for possible higher T_(c) R_(3)Ni_(2)O_(7) materials,which may be realized in further experiments.展开更多
Plants or tissues can be regenerated through various pathways.Like animal regeneration,cell totipotency and pluripotency are the molecular basis of plant regeneration.Detailed systematic studies on Arabidopsis thalian...Plants or tissues can be regenerated through various pathways.Like animal regeneration,cell totipotency and pluripotency are the molecular basis of plant regeneration.Detailed systematic studies on Arabidopsis thaliana gradually unravel the fundamental mechanisms and principles underlying plant regeneration.Specifically,plant hormones,cell division,epigenetic remodeling,and transcription factors play crucial roles in reprogramming somatic cells and reestablishing meristematic cells.Recent research on basal non-vascular plants and monocot crops has revealed that plant regeneration differs among species,with various plant species using distinct mechanisms and displaying significant differences in regenerative capacity.Conducting multi-omics studies at the single-cell level,tracking plant regeneration processes in real-time,and deciphering the natural variation in regenerative capacity will ultimately help understand the essence of plant regeneration,improve crop regeneration efficiency,and contribute to future crop design.展开更多
With the advancement of modern science and technology, large scientific facilities are increasingly oriented toward demand and application, and can be used for basic research as well as serving multiple disciplines. D...With the advancement of modern science and technology, large scientific facilities are increasingly oriented toward demand and application, and can be used for basic research as well as serving multiple disciplines. Developing large scientific facilities and related analytical technologies enhances understanding of large scientific facilities and popularizes their application in research across multiple disciplines. The combination of light or neutron sources from large scientific facilities and advanced analytical technologies can be achieved for materials structure information, dynamics study of chemical reactions, high dissociation of biomolecules, 3D visualization of energy materials or biological samples, etc. We first introduce the progress of domestic large scientific facilities of synchrotron radiation(SR) and free electron lasers(FELs) with different wavelengths and neutron sources.We further discuss the comparison between Chinese and typical foreign facilities in X-ray radiation from X-ray tubes, synchrotrons, X-ray FELs, and neutron sources based on physical parameters of light and neutron sources. In addition, we focus on the technological progress and perspectives combined with advanced X-ray radiation and neutron sources of large scientific facilities in China, especially in the nanoscience fields of energy catalysis and biological science. We hope that this roadmap will provide references on technology and methods to experimental users, as well as prospects for future development of technologies based on large research infrastructure facilities. Comprehensive studies and guidelines for basic research to practical application in various disciplines can be made with the assistance of large scientific facilities.展开更多
To compensate for their sessile nature,plants have evolved sophisticated mechanisms enabling them to adapt to ever-changing environments.One such prominent feature is the evolution of diverse life history strategies,p...To compensate for their sessile nature,plants have evolved sophisticated mechanisms enabling them to adapt to ever-changing environments.One such prominent feature is the evolution of diverse life history strategies,particularly such that annuals reproduce once followed by seasonal death,while perennials live longer by cycling growth seasonally.This intrinsic phenology is primarily genetic and can be altered by environmental factors.Although evolutionary transitions between annual and perennial life history strategies are common,perennials account for most species in nature because they survive well under year-round stresses.This proportion,however,is reversed in agriculture.Hence,perennial crops promise to likewise protect and enhance the resilience of agricultural ecosystems in response to climate change.Despite significant endeavors that have been made to generate perennial crops,progress is slow because of barriers in studying perennials,and many developed species await further improvement.Recent findings in model species have illustrated that simply rewiring existing genetic networks can lead to lifestyle variation.This implies that engineering plant life history strategy can be achieved by manipulating only a few key genes.In this review,we summarize our current understanding of genetic basis of perenniality and discuss major questions and challenges that remain to be addressed.展开更多
Abnormal tumor microenvironment imposes barriers to tumor penetration of nanomedicine,which remains a major challenge for effective anti-tumor.Herein,we present disulfide-based nanoparticles that actively penetrate de...Abnormal tumor microenvironment imposes barriers to tumor penetration of nanomedicine,which remains a major challenge for effective anti-tumor.Herein,we present disulfide-based nanoparticles that actively penetrate deep tumors in vivo through a thiol-mediated transportation pathway.To achieve active tumor accumulation in vivo,disulfide-based nanoparticles are modified with folic acid units(FA-DBNPs).It is gratifying that FA-DBNPs still enter cells via the thiol-mediated pathway,which facilitates transcellular transportation and tumor penetration both in vitro and in vivo.Besides,FA-DBNPs exhibit GSH concentration-dependent depolymerization characterization,indicating that the GSH level in tumor tissues regulates the penetration depth of FA-DBNPs.Benefiting from these advantages,FA-DBNPs showed potent anti-tumor activity in mouse models,leading to the significant regression of tumors.The current study lays a foundation that thiol-mediated transportation is a promising approach in nanomedicine design for solid tumor therapy.展开更多
Orderly hierarchical structure with balanced mechanical,chemical,and electrical properties is the basis of the natural bone microenvironment.Inspired by nature,we developed a piezocatalytically-induced controlled mine...Orderly hierarchical structure with balanced mechanical,chemical,and electrical properties is the basis of the natural bone microenvironment.Inspired by nature,we developed a piezocatalytically-induced controlled mineralization strategy using piezoelectric polymer poly-L-lactic acid(PLLA)fibers with ordered micro-nano structures to prepare biomimetic tissue engineering scaffolds with a bone-like microenvironment(pcm-PLLA),in which PLLA-mediated piezoelectric catalysis promoted the in-situ polymerization of dopamine and subsequently regulated the controllable growth of hydroxyapatite crystals on the fiber surface.PLLA fibers,as analogs of mineralized collagen fibers,were arranged in an oriented manner,and ultimately formed a bone-like interconnected pore structure;in addition,they also provided bone-like piezoelectric properties.The uniformly sized HA nanocrystals formed by controlled mineralization provided a bone-like mechanical strength and chemical environment.The pcm-PLLA scaffold could rapidly recruit endogenous stem cells,and promote their osteogenic differentiation by activating cell membrane calcium channels and PI3K signaling pathways through ultrasound-responsive piezoelectric signals.In addition,the scaffold also provided a suitable microenvironment to promote macrophage M2 polarization and angiogenesis,thereby enhancing bone regeneration in skull defects of rats.The proposed piezocatalytically-induced controllable mineralization strategy provides a new idea for the development of tissue engineering scaffolds that can be implemented for multimodal physical stimulation therapy.展开更多
High-temperature interactions induce sintering of metal nanoparticles(NPs) on heterogeneous catalyst surfaces, leading to reduced surface area and active site loss through Ostwald ripening [1]. This irreversible deact...High-temperature interactions induce sintering of metal nanoparticles(NPs) on heterogeneous catalyst surfaces, leading to reduced surface area and active site loss through Ostwald ripening [1]. This irreversible deactivation necessitates costly catalyst replacement, notably impacting metals like copper in hydrogenation and reforming reactions [2].展开更多
Plastics play a crucial role in modern society life. While the increasing use of plastics and rapid accumulation of plastic waste in nature environment have caused severe environmental crisis and the waste of carbon r...Plastics play a crucial role in modern society life. While the increasing use of plastics and rapid accumulation of plastic waste in nature environment have caused severe environmental crisis and the waste of carbon resources. Catalytic upcycling is a promising approach to transform plastic waste into high value-added chemicals to achieve a sustainable circular economy.展开更多
Photocatalytic water oxidation reaction by transition metal complexes remains a challenge because of their poor stability under irradiation,especially for earth-abundant metal catalysts.In this regard,ironbased water ...Photocatalytic water oxidation reaction by transition metal complexes remains a challenge because of their poor stability under irradiation,especially for earth-abundant metal catalysts.In this regard,ironbased water oxidation catalysts are prone to hydrolysis and/or dissociate the ligands to form nanoparticles under a real catalytic condition.Herein,we describe a unique hexa-coordinated catalyst 1[Fe^(II)(Py_(3)tacn)Cl_(2)]and its reference 2[Fe^(II)(PhPy_(2)tacn)Cl_(2)]with a dangling pyridyl ligand and a phenyl group,respectively.We anticipated that the dynamically open and close coordination behaviors of the pyridyl ligand enabled balance of the reactivity and stability of catalyst 1.To our delight,the“open form”of catalyst 1 provided a free coordination site,and the“close form”guaranteed its molecular integrity,resulting in a water oxidation reaction with high efficiency and robustness.The turnover number and turnover frequency values of 2332 and 60 s^(−1)are the highest known to date among iron-based homogeneous water oxidation systems under visible light irradiation.展开更多
In vascular plants,roots are important underground organs that anchor the plant in the ground and absorb water and many elemental nutrients from the soil.Root system architecture(RSA)plays critical roles in not only d...In vascular plants,roots are important underground organs that anchor the plant in the ground and absorb water and many elemental nutrients from the soil.Root system architecture(RSA)plays critical roles in not only determining a plant’s ability to acquire soil resources but also improving plant survival under various dynamic environmental conditions.展开更多
The live-cell biomolecular dynamics refers to the rapid movement,interacting with their surroundings,and the transformation of biomolecules within living cells.Deeper understanding of biomolecular dynamics in their na...The live-cell biomolecular dynamics refers to the rapid movement,interacting with their surroundings,and the transformation of biomolecules within living cells.Deeper understanding of biomolecular dynamics in their native state may reveal fundamental molecular mechanisms of cell function and disease formation[1].Also,understanding the disease associated biomolecular dynamics can assist in disease diagnosis and therapy.展开更多
Advances in luminescence materials have markedly propelled research in light theranostics,spanning luminescence biosensing[1],in vivo optical imaging[2],photodynamic therapy[3],optogenetics[4],and related fields[5-7]....Advances in luminescence materials have markedly propelled research in light theranostics,spanning luminescence biosensing[1],in vivo optical imaging[2],photodynamic therapy[3],optogenetics[4],and related fields[5-7].Nevertheless,conventional light sources have limited penetration depths within deep tissues,and the current state of light theranostics in superficial tissues does not fulfill the requirements for deep tissue treatments in clinical applications.展开更多
The efficient production of high-quality scintillators with long radioluminescence afterglow is crucial for high-performance X-ray luminescence extension imaging.However,scaling-up the synthesis of ligand-free scintil...The efficient production of high-quality scintillators with long radioluminescence afterglow is crucial for high-performance X-ray luminescence extension imaging.However,scaling-up the synthesis of ligand-free scintillators to fabricate large-area X-ray imaging screens for industrial applications remains a challenge.In this study,we report an efficient method to synthesize ligand-free,lanthanide-doped microscintillators by a one-pot reaction via the concentrated hydrothermal method.The as-synthesized microscintillators exhibit prolonged persistent radioluminescence for up to 30 days after X-ray exposure and remain high stability in air or water for more than 18 months without deterioration.Monte Carlo simulations indicate that the size effect is responsible for the excellent afterglow performance of the microscintillators.We employ these high-quality lanthanide-doped microscintillators to fabricate a large-area X-ray imaging detector using a blade-coating method,a spatial resolution of 24.9 lp/mm for X-ray imaging.Our study offers a solution for scaling-up the synthesis of low-cost microscintillators for practical applications.展开更多
Hybrid breeding plays an important role in increasing crop yields by taking advantage of hybrid vigor,which helps crops grow with superior yields across various climates and contributes to ensuring secure food product...Hybrid breeding plays an important role in increasing crop yields by taking advantage of hybrid vigor,which helps crops grow with superior yields across various climates and contributes to ensuring secure food production.Hybrid seed production is relatively straightforward and simple in cross-pollinating plants such as maize but is difficult in self-pollinating plants such as rice,wheat,and soybean.Therefore,breeders have developed a three-line breeding strategy,utilizing a sterile line,a maintainer line,and a restorer line,for breeding hybrid rice(Figure 1A;Yuan,1966).展开更多
A new approach to allylic alkylation is realized using an atomically dispersed palladium catalyst(Pd1/TiO2-EG).Unlike conventional methods that require derivation of substrates and utilization of additives,this method...A new approach to allylic alkylation is realized using an atomically dispersed palladium catalyst(Pd1/TiO2-EG).Unlike conventional methods that require derivation of substrates and utilization of additives,this method allows for direct allylic alkylation from allylic alcohols,producing H2O as the sole by-product.The catalyst's high efficiency is attributed to the local hydrogen bonding at the or-ganic-inorganic interface(Pd-EG interface),facilitating hydroxyl group activation forη3π-allyl complex formation.The system demonstrates successful direct C—O and C—C coupling reactions with high selectivity,requiring no additives.This study highlights the potential of supported atomically dispersed catalysts for greener and more efficient catalysis,meanwhile,offers unique insights into the distinct behavior of atomically dispersed catalysts in comparison to homogeneous or nanoparticle-based catalysts.展开更多
Topological photonic insulators show promise for applications in compact integrated photonic circuits due to their ability to transport light robustly through sharp bendings.The number of topological edge states relie...Topological photonic insulators show promise for applications in compact integrated photonic circuits due to their ability to transport light robustly through sharp bendings.The number of topological edge states relies on the difference between the bulk Chern numbers across the boundary,as dictated by the bulk edge correspondence.The interference among multiple topological edge modes in topological photonics systems may allow for controllable functionalities that are particularly desirable for constructing reconfigurable photonic devices.In this work,we demonstrate magnetically controllable multimode interference based on gyromagnetic topological photonic insulators that support two unidirectional edge modes with different dispersions.We successfully achieve controllable power splitting in experiments by engineering multimode interference with the magnetic field intensity or the frequency of wave.Our work demonstrates that manipulating the interference among multiple chiral edge modes can facilitate the advancement of highly efficient and adaptable microwave devices.展开更多
It is important and challenging to analyze nanocluster structure with atomic precision.Herein,α-hemolysin nanopore was used to identify nanoclusters at the single molecule level by providing two-dimensional(2D)dwell ...It is important and challenging to analyze nanocluster structure with atomic precision.Herein,α-hemolysin nanopore was used to identify nanoclusters at the single molecule level by providing two-dimensional(2D)dwell time–current blockage spectra and translocation event frequency which sensitively depended on their structures.Nanoclusters such as Anderson,Keggin,Dawson,and a few lacunary Dawson polyoxometalates with very similar structures,even with only a two-atom difference,could be discriminated.This nanopore device could simultaneously measure multiple nanoclusters in a mixture qualitatively and quantitatively.Furthermore,molecular dynamics(MD)simulations provided microscopic understandings of the nanocluster translocation dynamics and yielded 2D dwell time–current blockage spectra in close agreement with experiments.The nanopore platform provides a novel powerful tool for nanocluster characterization.展开更多
Organic scintillators that efficiently generate bright triplet excitons are of critical importance for highperformance X-ray-excited luminescence in radiation detection.However,the nature of triplet-singlet spinforbid...Organic scintillators that efficiently generate bright triplet excitons are of critical importance for highperformance X-ray-excited luminescence in radiation detection.However,the nature of triplet-singlet spinforbidden transitions in these materials often result in long-lived phosphorescence,which is undesirable for ultrafast X-ray detection and imaging.Here we demonstrate that the effect of hybridized local and charge-transfer(HLCT)excited states enables organic scintillators to exhibit highly efficient and fast radioluminescence(RL)in response to X-ray irradiation.Our experimental and theoretical investigation shows that the oxidized 1,8-naphthalimide-phenothiazine dyad(OMNI-PTZ 2)with HLCT-excited states has an enhanced overlap integral of the highest occupied molecular orbital(HOMO)and lowest unoccupied molecular orbital(LUMO)on MNIπ-orbitals,and moderate donor–acceptor electron interactions.As a result,the RL of these crystals exhibits a 61-fold increase and its monoexponential decay lifetime is three orders of magnitude faster compared to its corresponding thermally activated delayed fluorescence(TADF)molecule MNI-PTZ 1.We further demonstrate the practical utility of the OMNI-PTZ 2(G)in high-performance X-ray detection and imaging,achieving an X-ray dose sensitivity of 97 nGy s−1 and an exceptional spatial resolution of 20 lp/mm.Our study provides a promising molecular design principle for utilizing triplet excitons to develop high-efficiency and fast X-ray scintillators for the development of next-generation flexible and stretchable X-ray imaging detectors.展开更多
Spontaneous time-reversal symmetry breaking plays an important role in studying strongly correlated unconventional superconductors.When two superconducting gap functions with different symmetries compete,the relative ...Spontaneous time-reversal symmetry breaking plays an important role in studying strongly correlated unconventional superconductors.When two superconducting gap functions with different symmetries compete,the relative phase channel(θ_(-)≡θ_(1)-θ_(2))exhibits an Ising-type Z_(2) symmetry due to the second order Josephson coupling,where θ_(1,2) are the phases of two gap functions.In contrast,the U(1) symmetry in the channel of θ_(+)≡(θ_(1)+θ_(2))/2 is intact.The phase locking,i.e.,ordering of θ_(-),can take place in the phase fluctuation regime before the onset of superconductivity,i.e.,when θ_(+) is disordered.If θ_(-) is pinned at ±π/2,then timereversal symmetry is broken in the normal state,otherwise,if θ_(-)=0,or,π,rotational symmetry is broken,leading to a nematic normal state.In both cases,the order parameters possess a 4-fermion structure beyond the scope of mean-field theory,which can be viewed as a high order symmetry breaking.We employ an effective two-component XY-model assisted by a renormalization group analysis to address this problem.As a natural by-product,we also find the other interesting intermediate phase corresponds to ordering of θ_+ but with θ_(-)disordered.This is the quartetting,or,charge-4e,superconductivity,which occurs above the low temperature Z_(2)-breaking charge-2e superconducting phase.Our results provide useful guidance for studying novel symmetry breaking phases in strongly correlated superconductors.展开更多
基金Project supported by the Ministry of Science and Technology of China (Grant No. 2022YFA1403800)the National Natural Science Foundation of China (Grant Nos. U2032204,12188101, and U22A6005)+2 种基金the Chinese Academy of Sciences (Grant No. XDB33000000)the Synergetic Extreme Condition User Facility (SECUF)the Center for Materials Genome。
文摘Manipulating emergent quantum phenomena is a key issue for understanding the underlying physics and contributing to possible applications.Here we study the evolution of insulating ground states of Ta_(2)Pu_(3)Te_(5) and Ta_(2)Ni_(3)Te_(5) under in-situ surface potassium deposition via angle-resolved photoemission spectroscopy.Our results confirm the excitonic insulator character of Ta_(2)d_(3)Te_(5).Upon surface doping,the size of its global gap decreases obviously.After a deposition time of more than 7 min,the potassium atoms induce a metal-insulator phase transition and make the system recover to a normal state.In contrast,our results show that the isostructural compound Ta_(2)Ni_(3)Te_(5) is a conventional insulator.The size of its global gap decreases upon surface doping,but persists positive throughout the doping process.Our results not only confirm the excitonic origin of the band gap in Ta_(2)Pd_(3)Te_(5),but also offer an effective method for designing functional quantum devices in the future.
基金supported by the National Natural Science Foundation of China(Grant Nos.12234016,12174317,and 12074031)the New Cornerstone Science Foundation.
文摘Recently,high temperature(T_(c)≈80 K)superconductivity(SC)has been discovered in La_(3)Ni_(2)O_(7)(LNO)under pressure.This raises the question of whether the superconducting transition temperature T_(c) could be further enhanced under suitable conditions.One possible route for achieving higher T_(c) is element substitution.Similar SC could appear in the Fmmm phase of rare-earth(RE)R_(3)Ni_(2)O_(7)(RNO,R=RE element)material series under suitable pressure.The electronic properties in the RNO materials are dominated by the Ni 3d orbitals in the bilayer NiO_(2) plane.In the strong coupling limit,the SC could be fully characterized by a bilayer single 3d_(x^(2)−y^(2))-orbital t–J‖–J⊥ model.With RE element substitution from La to other RE element,the lattice constant of the Fmmm RNO material decreases,and the resultant electronic hopping integral increases,leading to stronger superexchanges between the 3d_(x^(2)−y^(2)) orbitals.Based on the slave-boson mean-field theory,we explore the pairing nature and the evolution of T_(c) in RNO materials under pressure.Consequently,it is found that the element substitution does not alter the pairing nature,i.e.,the inter-layer s-wave pairing is always favored in the superconducting RNO under pressure.However,the T_(c) increases from La to Sm,and a nearly doubled T_(c) could be realized in SmNO under pressure.This work provides evidence for possible higher T_(c) R_(3)Ni_(2)O_(7) materials,which may be realized in further experiments.
基金supported by the National Key Research and Development Program of China(2024YFE0102300)supported by the National Key Research and Development Program of China(2019YFA0903900,2023YFE0101100)+22 种基金supported by the National Key Research and Development Program of China(2021YFD1201500)the Advanced Foreign Experts Project(G2023157014L)the Cultivating Fund Project of Hubei Hongshan Laboratory(2022hspy002)Young Scientist Forstering Funds for the National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops(11909920008)supported by the National Natural Science Foundation of China(31830055,32170317)supported by the National Natural Science Foundation of China(32270377,32070199)the National Natural Science Foundation of China(31921005)supported by the National Natural Science Foundation of China(32225007)supported by the National Natural Science Foundation of China(32170325)supported by the National Natural Science Foundation of China(32321001,32130009)supported by the National Natural Science Foundation of China(32070874,32270299)supported by the National Natural Science Foundation of China(31788103)the Strategic Priority Research Program of CAS(XDB27030102)the Strategic Priority Research Program of CAS(XDB27030103)the Strategic Priority Research Program of CAS(XDB0630201)the Strategic Priority Research Program of CAS(XDB27030107)the Strategic Priority Research Program of CAS(XDB27030105)the Natural Science Foundation of Shandong Province(ZR2022JQ12)Beijing Natural Science Foundation Outstanding Youth Project(JQ23026)the Natural Science Foundation of Shanghai(21ZR1482500)the University of Science and Technology of China Research Funds of the Double First-Class Initiative(YD9100002025)the Pinduoduo-China Agricultural University Research Fund(PC2023B01006)the New Cornerstone Science Foundation through the XPLORER PRIZE。
文摘Plants or tissues can be regenerated through various pathways.Like animal regeneration,cell totipotency and pluripotency are the molecular basis of plant regeneration.Detailed systematic studies on Arabidopsis thaliana gradually unravel the fundamental mechanisms and principles underlying plant regeneration.Specifically,plant hormones,cell division,epigenetic remodeling,and transcription factors play crucial roles in reprogramming somatic cells and reestablishing meristematic cells.Recent research on basal non-vascular plants and monocot crops has revealed that plant regeneration differs among species,with various plant species using distinct mechanisms and displaying significant differences in regenerative capacity.Conducting multi-omics studies at the single-cell level,tracking plant regeneration processes in real-time,and deciphering the natural variation in regenerative capacity will ultimately help understand the essence of plant regeneration,improve crop regeneration efficiency,and contribute to future crop design.
基金supported by the National Basic Research Program of China (2022YFA1603701, 2021YFA1200900)the institutionalized scientific research platform relies on Beijing Synchrotron Radiation Facility of Chinese Academy of Sciences,the Strategic Priority Research Program of Chinese Academy of Sciences (XDB36000000)+2 种基金the National Natural Science Foundation of China (22027810, 82341044,22388101 and 22307028)the CAMS Innovation Fund for Medical Sciences(CIFMS 2019-I2M-5-018)the New Cornerstone Science Foundation。
文摘With the advancement of modern science and technology, large scientific facilities are increasingly oriented toward demand and application, and can be used for basic research as well as serving multiple disciplines. Developing large scientific facilities and related analytical technologies enhances understanding of large scientific facilities and popularizes their application in research across multiple disciplines. The combination of light or neutron sources from large scientific facilities and advanced analytical technologies can be achieved for materials structure information, dynamics study of chemical reactions, high dissociation of biomolecules, 3D visualization of energy materials or biological samples, etc. We first introduce the progress of domestic large scientific facilities of synchrotron radiation(SR) and free electron lasers(FELs) with different wavelengths and neutron sources.We further discuss the comparison between Chinese and typical foreign facilities in X-ray radiation from X-ray tubes, synchrotrons, X-ray FELs, and neutron sources based on physical parameters of light and neutron sources. In addition, we focus on the technological progress and perspectives combined with advanced X-ray radiation and neutron sources of large scientific facilities in China, especially in the nanoscience fields of energy catalysis and biological science. We hope that this roadmap will provide references on technology and methods to experimental users, as well as prospects for future development of technologies based on large research infrastructure facilities. Comprehensive studies and guidelines for basic research to practical application in various disciplines can be made with the assistance of large scientific facilities.
基金supported by grants from the National Natural Science Foundation of China(32388201,31721001)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB27030101)the New Cornerstone Science Foundation through the XPLORER PRIZE.No conflict of interest is declared。
文摘To compensate for their sessile nature,plants have evolved sophisticated mechanisms enabling them to adapt to ever-changing environments.One such prominent feature is the evolution of diverse life history strategies,particularly such that annuals reproduce once followed by seasonal death,while perennials live longer by cycling growth seasonally.This intrinsic phenology is primarily genetic and can be altered by environmental factors.Although evolutionary transitions between annual and perennial life history strategies are common,perennials account for most species in nature because they survive well under year-round stresses.This proportion,however,is reversed in agriculture.Hence,perennial crops promise to likewise protect and enhance the resilience of agricultural ecosystems in response to climate change.Despite significant endeavors that have been made to generate perennial crops,progress is slow because of barriers in studying perennials,and many developed species await further improvement.Recent findings in model species have illustrated that simply rewiring existing genetic networks can lead to lifestyle variation.This implies that engineering plant life history strategy can be achieved by manipulating only a few key genes.In this review,we summarize our current understanding of genetic basis of perenniality and discuss major questions and challenges that remain to be addressed.
基金supported by the National Key R&D Program of China(2020YFA0210800)the National Natural Science Foundation of China(21974022,22027805)the Major Project of Science and Technology of Fujian Province(2020HZ06006)。
文摘Abnormal tumor microenvironment imposes barriers to tumor penetration of nanomedicine,which remains a major challenge for effective anti-tumor.Herein,we present disulfide-based nanoparticles that actively penetrate deep tumors in vivo through a thiol-mediated transportation pathway.To achieve active tumor accumulation in vivo,disulfide-based nanoparticles are modified with folic acid units(FA-DBNPs).It is gratifying that FA-DBNPs still enter cells via the thiol-mediated pathway,which facilitates transcellular transportation and tumor penetration both in vitro and in vivo.Besides,FA-DBNPs exhibit GSH concentration-dependent depolymerization characterization,indicating that the GSH level in tumor tissues regulates the penetration depth of FA-DBNPs.Benefiting from these advantages,FA-DBNPs showed potent anti-tumor activity in mouse models,leading to the significant regression of tumors.The current study lays a foundation that thiol-mediated transportation is a promising approach in nanomedicine design for solid tumor therapy.
基金supported by Beijing Natural Science Foundation(L212010)the National Natural Science Foundation of China(T2125003,52372174)+1 种基金the New Cornerstone Science Foundation,Major Instrument Project of the National Natural Science Foundation of China(22027810)the National Key Research and Development Program of China(2022YFB3804703,2022YFE0111700,2021YFA1200900,2021YFB3201204,2022YFB3205602)。
文摘Orderly hierarchical structure with balanced mechanical,chemical,and electrical properties is the basis of the natural bone microenvironment.Inspired by nature,we developed a piezocatalytically-induced controlled mineralization strategy using piezoelectric polymer poly-L-lactic acid(PLLA)fibers with ordered micro-nano structures to prepare biomimetic tissue engineering scaffolds with a bone-like microenvironment(pcm-PLLA),in which PLLA-mediated piezoelectric catalysis promoted the in-situ polymerization of dopamine and subsequently regulated the controllable growth of hydroxyapatite crystals on the fiber surface.PLLA fibers,as analogs of mineralized collagen fibers,were arranged in an oriented manner,and ultimately formed a bone-like interconnected pore structure;in addition,they also provided bone-like piezoelectric properties.The uniformly sized HA nanocrystals formed by controlled mineralization provided a bone-like mechanical strength and chemical environment.The pcm-PLLA scaffold could rapidly recruit endogenous stem cells,and promote their osteogenic differentiation by activating cell membrane calcium channels and PI3K signaling pathways through ultrasound-responsive piezoelectric signals.In addition,the scaffold also provided a suitable microenvironment to promote macrophage M2 polarization and angiogenesis,thereby enhancing bone regeneration in skull defects of rats.The proposed piezocatalytically-induced controllable mineralization strategy provides a new idea for the development of tissue engineering scaffolds that can be implemented for multimodal physical stimulation therapy.
文摘High-temperature interactions induce sintering of metal nanoparticles(NPs) on heterogeneous catalyst surfaces, leading to reduced surface area and active site loss through Ostwald ripening [1]. This irreversible deactivation necessitates costly catalyst replacement, notably impacting metals like copper in hydrogenation and reforming reactions [2].
文摘Plastics play a crucial role in modern society life. While the increasing use of plastics and rapid accumulation of plastic waste in nature environment have caused severe environmental crisis and the waste of carbon resources. Catalytic upcycling is a promising approach to transform plastic waste into high value-added chemicals to achieve a sustainable circular economy.
基金support from the National Key Research and Development Program of China(grant nos.2022YFA1502900,2022YFA0911900,2021YFA1500800,and 2022YFB3803600)the National Natural Science Foundation of China(grant nos.20231001,22201288,21933007,22193013,and 22088102)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Science(grant no.XDB17000000)the New Cornerstone Science Foundation.
文摘Photocatalytic water oxidation reaction by transition metal complexes remains a challenge because of their poor stability under irradiation,especially for earth-abundant metal catalysts.In this regard,ironbased water oxidation catalysts are prone to hydrolysis and/or dissociate the ligands to form nanoparticles under a real catalytic condition.Herein,we describe a unique hexa-coordinated catalyst 1[Fe^(II)(Py_(3)tacn)Cl_(2)]and its reference 2[Fe^(II)(PhPy_(2)tacn)Cl_(2)]with a dangling pyridyl ligand and a phenyl group,respectively.We anticipated that the dynamically open and close coordination behaviors of the pyridyl ligand enabled balance of the reactivity and stability of catalyst 1.To our delight,the“open form”of catalyst 1 provided a free coordination site,and the“close form”guaranteed its molecular integrity,resulting in a water oxidation reaction with high efficiency and robustness.The turnover number and turnover frequency values of 2332 and 60 s^(−1)are the highest known to date among iron-based homogeneous water oxidation systems under visible light irradiation.
基金supported by the National Natural Science Foundation of China(31830082,32020103004,and 32170251)the New Cornerstone Investigation Program(NCI202234)。
文摘In vascular plants,roots are important underground organs that anchor the plant in the ground and absorb water and many elemental nutrients from the soil.Root system architecture(RSA)plays critical roles in not only determining a plant’s ability to acquire soil resources but also improving plant survival under various dynamic environmental conditions.
基金supported by the National Key R&D Program of China(2022YFA1603600)the National Natural Science Foundation of China(22122406,22104089,and 22204106)+2 种基金the Shenzhen Medical Research Fund(B2301003)the Guangdong Basic and Applied Basic Research Foundation(2021A1515110710)the Guangdong Provincial Pearl River Talents Program(2021QN02Z631)。
文摘The live-cell biomolecular dynamics refers to the rapid movement,interacting with their surroundings,and the transformation of biomolecules within living cells.Deeper understanding of biomolecular dynamics in their native state may reveal fundamental molecular mechanisms of cell function and disease formation[1].Also,understanding the disease associated biomolecular dynamics can assist in disease diagnosis and therapy.
基金supported by the National Key Research&Development Program of China(2020YFA0709903)the National Natural Science Foundation of China(22027805,62134003,22104016,22334004)the Natural Science Foundation of Fujian Province(2022J06008,2022J01709)。
文摘Advances in luminescence materials have markedly propelled research in light theranostics,spanning luminescence biosensing[1],in vivo optical imaging[2],photodynamic therapy[3],optogenetics[4],and related fields[5-7].Nevertheless,conventional light sources have limited penetration depths within deep tissues,and the current state of light theranostics in superficial tissues does not fulfill the requirements for deep tissue treatments in clinical applications.
基金the National Key Research&Development Program of China(Nos.2020YFA0709900,2020YFA0210800)the National Natural Science Foundation of China(Nos.22027805,62134003,22104016)+1 种基金the Natural Science Foundation of Fujian Province(Nos.2022J01709,2023J01384)the Major Project of Science and Technology of Fujian Province(No.2020HZ06006)。
文摘The efficient production of high-quality scintillators with long radioluminescence afterglow is crucial for high-performance X-ray luminescence extension imaging.However,scaling-up the synthesis of ligand-free scintillators to fabricate large-area X-ray imaging screens for industrial applications remains a challenge.In this study,we report an efficient method to synthesize ligand-free,lanthanide-doped microscintillators by a one-pot reaction via the concentrated hydrothermal method.The as-synthesized microscintillators exhibit prolonged persistent radioluminescence for up to 30 days after X-ray exposure and remain high stability in air or water for more than 18 months without deterioration.Monte Carlo simulations indicate that the size effect is responsible for the excellent afterglow performance of the microscintillators.We employ these high-quality lanthanide-doped microscintillators to fabricate a large-area X-ray imaging detector using a blade-coating method,a spatial resolution of 24.9 lp/mm for X-ray imaging.Our study offers a solution for scaling-up the synthesis of low-cost microscintillators for practical applications.
基金supported by the National Natural Science Foundation of China(32388201)the National Key Research and Development Program(2022YFF1002802)the Ministry of Agriculture and Rural Affairs of China,the Strategic Priority Research Program of the Chinese Academy of Sciences(Precision Seed Design and Breeding,XDA24020102) and the New Cornerstone Science Foundation through the New Cornerstone Investigator Program.
文摘Hybrid breeding plays an important role in increasing crop yields by taking advantage of hybrid vigor,which helps crops grow with superior yields across various climates and contributes to ensuring secure food production.Hybrid seed production is relatively straightforward and simple in cross-pollinating plants such as maize but is difficult in self-pollinating plants such as rice,wheat,and soybean.Therefore,breeders have developed a three-line breeding strategy,utilizing a sterile line,a maintainer line,and a restorer line,for breeding hybrid rice(Figure 1A;Yuan,1966).
基金support from National Key R&D Program of China (2022YFA1504500)the National Natural Science Foundation of China (grant no.92261207,and NSFC Center for Single-Atom Catalysis under grant no.22388102)+4 种基金the New Cornerstone Science Foundation.P.L.acknowledges the Shanghai Pujiang Talent Program (No.21PJ1410400)the Start-up Funding and the Double First-Class Initiative Fund of ShanghaiTech University.R.Q.acknowledges support from the Young Scientists Fund of the National Natural Science Foundation of China (22202164)the Natural Science Foundation of Fujian Province (2023J05006)the Fundamental Research Funds for the Central Universities (20720230002)the Fujian Provincial Chemistry Discipline Alliance.
文摘A new approach to allylic alkylation is realized using an atomically dispersed palladium catalyst(Pd1/TiO2-EG).Unlike conventional methods that require derivation of substrates and utilization of additives,this method allows for direct allylic alkylation from allylic alcohols,producing H2O as the sole by-product.The catalyst's high efficiency is attributed to the local hydrogen bonding at the or-ganic-inorganic interface(Pd-EG interface),facilitating hydroxyl group activation forη3π-allyl complex formation.The system demonstrates successful direct C—O and C—C coupling reactions with high selectivity,requiring no additives.This study highlights the potential of supported atomically dispersed catalysts for greener and more efficient catalysis,meanwhile,offers unique insights into the distinct behavior of atomically dispersed catalysts in comparison to homogeneous or nanoparticle-based catalysts.
基金the Research Grants Council of Hong Kong(AoE/P-502/20,17309021,16303119,16310420)the Croucher Foundation(CAS20SC01)and New Cornerstone Science Foundation.
文摘Topological photonic insulators show promise for applications in compact integrated photonic circuits due to their ability to transport light robustly through sharp bendings.The number of topological edge states relies on the difference between the bulk Chern numbers across the boundary,as dictated by the bulk edge correspondence.The interference among multiple topological edge modes in topological photonics systems may allow for controllable functionalities that are particularly desirable for constructing reconfigurable photonic devices.In this work,we demonstrate magnetically controllable multimode interference based on gyromagnetic topological photonic insulators that support two unidirectional edge modes with different dispersions.We successfully achieve controllable power splitting in experiments by engineering multimode interference with the magnetic field intensity or the frequency of wave.Our work demonstrates that manipulating the interference among multiple chiral edge modes can facilitate the advancement of highly efficient and adaptable microwave devices.
基金supported by the National Key Research and Development Program of China(No.2021YFA1200104)New Cornerstone Science Foundation,the National Natural Science Foundation of China(Nos.22027807,22034004,and 22078104)+1 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000)Tsinghua-Vanke Special Fund for Public Health and Health Discipline Development(No.2022Z82WKJ003).
文摘It is important and challenging to analyze nanocluster structure with atomic precision.Herein,α-hemolysin nanopore was used to identify nanoclusters at the single molecule level by providing two-dimensional(2D)dwell time–current blockage spectra and translocation event frequency which sensitively depended on their structures.Nanoclusters such as Anderson,Keggin,Dawson,and a few lacunary Dawson polyoxometalates with very similar structures,even with only a two-atom difference,could be discriminated.This nanopore device could simultaneously measure multiple nanoclusters in a mixture qualitatively and quantitatively.Furthermore,molecular dynamics(MD)simulations provided microscopic understandings of the nanocluster translocation dynamics and yielded 2D dwell time–current blockage spectra in close agreement with experiments.The nanopore platform provides a novel powerful tool for nanocluster characterization.
基金supported by the National Key R&D Program of China(grant no.2020YFA0709900)the National Natural Science Foundation of China(grant nos.21971041,22201042,22027805,62134003,and 22104016)+2 种基金the Natural Science Foundation of Fujian Province(grant nos.2020J01447,2022J06008,and 2022J0121)the Research Foundation of Education Bureau of Fujian Province(grant no.JAT210001)the Fuzhou University Testing Fund of Precious Apparatus(grant no.2022T001).
文摘Organic scintillators that efficiently generate bright triplet excitons are of critical importance for highperformance X-ray-excited luminescence in radiation detection.However,the nature of triplet-singlet spinforbidden transitions in these materials often result in long-lived phosphorescence,which is undesirable for ultrafast X-ray detection and imaging.Here we demonstrate that the effect of hybridized local and charge-transfer(HLCT)excited states enables organic scintillators to exhibit highly efficient and fast radioluminescence(RL)in response to X-ray irradiation.Our experimental and theoretical investigation shows that the oxidized 1,8-naphthalimide-phenothiazine dyad(OMNI-PTZ 2)with HLCT-excited states has an enhanced overlap integral of the highest occupied molecular orbital(HOMO)and lowest unoccupied molecular orbital(LUMO)on MNIπ-orbitals,and moderate donor–acceptor electron interactions.As a result,the RL of these crystals exhibits a 61-fold increase and its monoexponential decay lifetime is three orders of magnitude faster compared to its corresponding thermally activated delayed fluorescence(TADF)molecule MNI-PTZ 1.We further demonstrate the practical utility of the OMNI-PTZ 2(G)in high-performance X-ray detection and imaging,achieving an X-ray dose sensitivity of 97 nGy s−1 and an exceptional spatial resolution of 20 lp/mm.Our study provides a promising molecular design principle for utilizing triplet excitons to develop high-efficiency and fast X-ray scintillators for the development of next-generation flexible and stretchable X-ray imaging detectors.
基金supported by a startup funding of UCSD and the National Science Foundation (Grant No. DMR-2238360)supported by the National Natural Science Foundation of China (Grant Nos. 12234016, and 12174317)supported by the New Cornerstone Science Foundation。
文摘Spontaneous time-reversal symmetry breaking plays an important role in studying strongly correlated unconventional superconductors.When two superconducting gap functions with different symmetries compete,the relative phase channel(θ_(-)≡θ_(1)-θ_(2))exhibits an Ising-type Z_(2) symmetry due to the second order Josephson coupling,where θ_(1,2) are the phases of two gap functions.In contrast,the U(1) symmetry in the channel of θ_(+)≡(θ_(1)+θ_(2))/2 is intact.The phase locking,i.e.,ordering of θ_(-),can take place in the phase fluctuation regime before the onset of superconductivity,i.e.,when θ_(+) is disordered.If θ_(-) is pinned at ±π/2,then timereversal symmetry is broken in the normal state,otherwise,if θ_(-)=0,or,π,rotational symmetry is broken,leading to a nematic normal state.In both cases,the order parameters possess a 4-fermion structure beyond the scope of mean-field theory,which can be viewed as a high order symmetry breaking.We employ an effective two-component XY-model assisted by a renormalization group analysis to address this problem.As a natural by-product,we also find the other interesting intermediate phase corresponds to ordering of θ_+ but with θ_(-)disordered.This is the quartetting,or,charge-4e,superconductivity,which occurs above the low temperature Z_(2)-breaking charge-2e superconducting phase.Our results provide useful guidance for studying novel symmetry breaking phases in strongly correlated superconductors.