Aim： To study the relationship between circulating androgens （total testosterone [TT], free testosterone [IT] and dihydrotestosterone [DHT]） and high-density lipoprotein cholesterol （HDL-C） in men with and withou...Aim： To study the relationship between circulating androgens （total testosterone [TT], free testosterone [IT] and dihydrotestosterone [DHT]） and high-density lipoprotein cholesterol （HDL-C） in men with and without cardiovascular disease （CVD）. Methods： Cross-sectional analyses included 1 661 baseline samples from the Massachusetts Male Aging Study （MMAS）, a population-based cohort of men ages 40-70 years. Serum hormones were measured by radioimmunoassay and HDL-C was determined following precipitation of the lower density lipoproteins. CVD was determined by self-report. Analyses were performed using multiple linear regression. Results： TT and HDL-C were positively correlated in the entire sample （r = 0.11, P = 0.0001）. After adjusting for confounders, we found this relationship was mostly limited to the 209 men with CVD. Among men with CVD, TT （P = 0.0004）, iT （P = 0.0172） and DHT （P = 0.0128） were all positively correlated with HDL-C, whereas in men without CVD only TT correlated with HDL-C （P = 0.0099）. Conclusion： Our results suggest that if androgens contribute to CVD in middle-aged men, the effect is not related to a suppressive effect of endogenous T on HDL-C. （Asian JAndrol 2008 Mar; 10： 193-200）展开更多
Context: No randomized trials have been published that address the concern that inhalation of mercury vapor released by amalgam dental restorations causes adverse health effects. Objective: To compare the neuropsychol...Context: No randomized trials have been published that address the concern that inhalation of mercury vapor released by amalgam dental restorations causes adverse health effects. Objective: To compare the neuropsychological and renal function of children whose dental caries were restored using amalgam or mercury- free materials. Design and Setting The New England Children’ s Amalgam Trial was a 2- group randomized safety trial involving 5 community health dental clinics in Boston, Mass, and 1 in Farmington, Me, between September 1997 and March 2005. Participants and Intervention: A total of 534 children aged 6 to 10 years at baseline with no prior amalgam restorations and 2 or more posterior teeth with caries were randomly assigned to receive dental restoration of baseline and incident caries during a 5- year follow- up period using either amalgam (n=267) or resin composite (n =267) materials. Main Outcome Measures: The primary neuropsychological outcome was 5- year change in fullscale IQ scores. Secondary outcomes included tests of memory and visuomotor ability. Renal glomerular function was measured by creatinine- adjusted albumin in urine. Results: Children had a mean of 15 tooth surfaces (median, 14) restored during the 5- year period (range, 0- 55). Assignment to the amalgam group was associated with a significantly higher mean urinary mercury level (0.9 vs 0.6 μ g/g of creatinine at year 5, P < 0.001). After adjusting for randomization stratum and other covariates, no statistically significant differences were found between children in the amalgam and composite groups in 5- year change in full- scale IQ score (3.1 vs 2.1, P=0.21). The difference in treatment group change scores was 1.0 (95% confidence interval, - 0.6 to 2.5) full- scale IQ score point. No statistically significant differences were found for 4- year change in the general memory index (8.1 vs 7.2, P=0.34), 4- year change in visuomotor composite (3.8 vs 3.7, P=0.93), or year 5 urinary albumin (median, 7.5 vs 7.4 mg/g of creatinine, P=0.61). Conclusions: In this study, there were no statistically significant differences in adverse neuropsychological or renal effects observed over the 5- year period in children whose caries were restored using dental amalgam or composite materials. Although it is possible that very small IQ effects cannot be ruled out, these findings suggest that the health effects of amalgam restorations in children need not be the basis of treatment decisions when choosing restorative dental materials.展开更多
Context: No randomized trials have been published that address the concern that inhalation of mercury vapor released by amalgam dental restorations causes adverse health effects. Objective: To compare the neuropsychol...Context: No randomized trials have been published that address the concern that inhalation of mercury vapor released by amalgam dental restorations causes adverse health effects. Objective: To compare the neuropsychological and renal function of children whose dental caries were restored using amalgam or mercury-free materials. Design and Setting The New England Children’s Amalgam Trial was a 2-group randomized safety trial involving 5 community health dental clinics in oston, Mass, and 1 in Farmington, Me, between September 1997 and March 2005. Participants and Intervention: A total of 534 children aged 6 to 10 years at baseline with no prior amalgam restorations and 2 or more posterior teeth with caries were randomly assigned to receive dental restoration of baseline and incident caries during a 5-year follow-up period using either amalgam (n=267) or resin composite (n =267) materials. Main Outcome Measures: The primary neuropsychological outcome was 5-year change in full-scale IQ scores. Secondary outcomes included tests of memory and visuomotor ability. Renal glomerular function was measured by creatinine-adjusted albumin in urine. Results: Children had a mean of 15 tooth surfaces (median, 14) restored during the 5-year period (range, 0-55). Assignment to the amalgam group was associated with a significantly higher mean urinary mercury level (0.9 vs 0.6 μg/g of creatinine at year 5, P < .001). After adjusting for randomization stratum and other covariates, no statistically significant differences were found between children in the amalgam and composite groups in 5-year change in full-scale IQ score (3.1 vs 2.1, P=.21). The difference in treatment group change scores was 1.0 (95%confidence interval, -0.6 to 2.5) full-scale IQ score point. No statistically significant differences were found for 4-year change in the general memory index (8.1 vs 7.2, P=.34), 4-year change in visuomotor composite (3.8 vs 3.7, P=.93), or year 5 urinary albumin (median, 7.5 vs 7.4 mg/g of creatinine, P=.61). Conclusions: In this study, there were no statistically significant differences in adverse neuropsychologicalor renal effects observed over the 5-year period in children whose caries were restored using dental amalgam or composite materials. Although it is possible that very small IQ effects cannot be ruled out, these findings suggest that the health effects of amalgam restorations in children need not be the basis of treatment decisions when choosing restorative dental materials.展开更多
文摘Aim： To study the relationship between circulating androgens （total testosterone [TT], free testosterone [IT] and dihydrotestosterone [DHT]） and high-density lipoprotein cholesterol （HDL-C） in men with and without cardiovascular disease （CVD）. Methods： Cross-sectional analyses included 1 661 baseline samples from the Massachusetts Male Aging Study （MMAS）, a population-based cohort of men ages 40-70 years. Serum hormones were measured by radioimmunoassay and HDL-C was determined following precipitation of the lower density lipoproteins. CVD was determined by self-report. Analyses were performed using multiple linear regression. Results： TT and HDL-C were positively correlated in the entire sample （r = 0.11, P = 0.0001）. After adjusting for confounders, we found this relationship was mostly limited to the 209 men with CVD. Among men with CVD, TT （P = 0.0004）, iT （P = 0.0172） and DHT （P = 0.0128） were all positively correlated with HDL-C, whereas in men without CVD only TT correlated with HDL-C （P = 0.0099）. Conclusion： Our results suggest that if androgens contribute to CVD in middle-aged men, the effect is not related to a suppressive effect of endogenous T on HDL-C. （Asian JAndrol 2008 Mar; 10： 193-200）
文摘Context: No randomized trials have been published that address the concern that inhalation of mercury vapor released by amalgam dental restorations causes adverse health effects. Objective: To compare the neuropsychological and renal function of children whose dental caries were restored using amalgam or mercury- free materials. Design and Setting The New England Children’ s Amalgam Trial was a 2- group randomized safety trial involving 5 community health dental clinics in Boston, Mass, and 1 in Farmington, Me, between September 1997 and March 2005. Participants and Intervention: A total of 534 children aged 6 to 10 years at baseline with no prior amalgam restorations and 2 or more posterior teeth with caries were randomly assigned to receive dental restoration of baseline and incident caries during a 5- year follow- up period using either amalgam (n=267) or resin composite (n =267) materials. Main Outcome Measures: The primary neuropsychological outcome was 5- year change in fullscale IQ scores. Secondary outcomes included tests of memory and visuomotor ability. Renal glomerular function was measured by creatinine- adjusted albumin in urine. Results: Children had a mean of 15 tooth surfaces (median, 14) restored during the 5- year period (range, 0- 55). Assignment to the amalgam group was associated with a significantly higher mean urinary mercury level (0.9 vs 0.6 μ g/g of creatinine at year 5, P < 0.001). After adjusting for randomization stratum and other covariates, no statistically significant differences were found between children in the amalgam and composite groups in 5- year change in full- scale IQ score (3.1 vs 2.1, P=0.21). The difference in treatment group change scores was 1.0 (95% confidence interval, - 0.6 to 2.5) full- scale IQ score point. No statistically significant differences were found for 4- year change in the general memory index (8.1 vs 7.2, P=0.34), 4- year change in visuomotor composite (3.8 vs 3.7, P=0.93), or year 5 urinary albumin (median, 7.5 vs 7.4 mg/g of creatinine, P=0.61). Conclusions: In this study, there were no statistically significant differences in adverse neuropsychological or renal effects observed over the 5- year period in children whose caries were restored using dental amalgam or composite materials. Although it is possible that very small IQ effects cannot be ruled out, these findings suggest that the health effects of amalgam restorations in children need not be the basis of treatment decisions when choosing restorative dental materials.
文摘Context: No randomized trials have been published that address the concern that inhalation of mercury vapor released by amalgam dental restorations causes adverse health effects. Objective: To compare the neuropsychological and renal function of children whose dental caries were restored using amalgam or mercury-free materials. Design and Setting The New England Children’s Amalgam Trial was a 2-group randomized safety trial involving 5 community health dental clinics in oston, Mass, and 1 in Farmington, Me, between September 1997 and March 2005. Participants and Intervention: A total of 534 children aged 6 to 10 years at baseline with no prior amalgam restorations and 2 or more posterior teeth with caries were randomly assigned to receive dental restoration of baseline and incident caries during a 5-year follow-up period using either amalgam (n=267) or resin composite (n =267) materials. Main Outcome Measures: The primary neuropsychological outcome was 5-year change in full-scale IQ scores. Secondary outcomes included tests of memory and visuomotor ability. Renal glomerular function was measured by creatinine-adjusted albumin in urine. Results: Children had a mean of 15 tooth surfaces (median, 14) restored during the 5-year period (range, 0-55). Assignment to the amalgam group was associated with a significantly higher mean urinary mercury level (0.9 vs 0.6 μg/g of creatinine at year 5, P < .001). After adjusting for randomization stratum and other covariates, no statistically significant differences were found between children in the amalgam and composite groups in 5-year change in full-scale IQ score (3.1 vs 2.1, P=.21). The difference in treatment group change scores was 1.0 (95%confidence interval, -0.6 to 2.5) full-scale IQ score point. No statistically significant differences were found for 4-year change in the general memory index (8.1 vs 7.2, P=.34), 4-year change in visuomotor composite (3.8 vs 3.7, P=.93), or year 5 urinary albumin (median, 7.5 vs 7.4 mg/g of creatinine, P=.61). Conclusions: In this study, there were no statistically significant differences in adverse neuropsychologicalor renal effects observed over the 5-year period in children whose caries were restored using dental amalgam or composite materials. Although it is possible that very small IQ effects cannot be ruled out, these findings suggest that the health effects of amalgam restorations in children need not be the basis of treatment decisions when choosing restorative dental materials.
